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5G10	Pseudomonas aeruginosa HDAH bound to 9,9,9 trifluoro-8,8-dihydroy-N-phenylnonanamide Descriptor: 9,9,9-tris(fluoranyl)-8,8-bis(oxidanyl)-~{N}-phenyl-nonanamide, HDAH, POTASSIUM ION, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-23 Release date: 2016-11-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa. Biochemistry, 55, 2016
5EF7	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HPOB Descriptor: 4-[2-[2-hydroxyethyl(phenyl)amino]-2-oxidanylidene-ethyl]-~{N}-oxidanyl-benzamide, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFN	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (H574A) in complex with histone H4 Lys6 tripeptide substrate Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-24 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.804 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEI	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with SAHA Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-22 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFG	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with acetate Descriptor: ACETATE ION, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEK	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trichostatin A Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, CHLORIDE ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEF	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 in complex with trichostatin A Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, HDAC6, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-22 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.151 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5FUE	Crystal structure of Schistosoma mansoni HDAC8 complexed with 3- benzamido-benzohydroxamate Descriptor: 3-(benzoylamino)-N-oxobenzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... Authors: Marek, M, Romier, C. Deposit date: 2016-01-26 Release date: 2016-03-09 Last modified: 2016-04-06 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Structure-Based Design and Synthesis of Novel Inhibitors Targeting Hdac8 from Schistosoma Mansoni for the Treatment of Schistosomiasis. J.Med.Chem., 59, 2016
5EEN	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with belinostat Descriptor: Belinostat, CHLORIDE ION, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.861 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFK	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (Y745F mutant) in complex with alpha tubulin K40 tripeptide substrate Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, DI(HYDROXYETHYL)ETHER, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFH	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue Descriptor: 1,2-ETHANEDIOL, 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, BROMIDE ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.162 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EF8	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFJ	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HC toxin Descriptor: 1,2-ETHANEDIOL, GLYCEROL, HC toxin, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEM	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 Descriptor: FORMIC ACID, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5G1C	Structure of HDAC like protein from Bordetella Alcaligenes bound the photoswitchable pyrazole Inhibitor CEW395 Descriptor: (2E)-N-hydroxy-3-{4-[(E)-(1,3,5-trimethyl-1H-pyrazol-4-yl)diazenyl]phenyl}prop-2-enamide, DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-24 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
5G0J	Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with Nexturastat A Descriptor: CHLORIDE ION, HDAC6, NEXTURASTAT A, ... Authors: Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. Deposit date: 2016-03-18 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
5G1B	Bordetella Alcaligenes HDAH native Descriptor: DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, PENTAETHYLENE GLYCOL, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-24 Release date: 2017-04-12 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket. Biochim. Biophys. Acta, 1861, 2017
5G11	Pseudomonas aeruginosa HDAH bound to PFSAHA. Descriptor: 2,2,3,3,4,4,5,5,6,6,7,7-dodecakis(fluoranyl)-~{N}-oxidanyl-~{N}'-phenyl-octanediamide, HDAH, POTASSIUM ION, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-23 Release date: 2016-11-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa. Biochemistry, 55, 2016
5G0G	Crystal structure of Danio rerio HDAC6 CD1 in complex with trichostatin A Descriptor: CHLORIDE ION, HDAC6, SODIUM ION, ... Authors: Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. Deposit date: 2016-03-18 Release date: 2016-07-27 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
8GA8	Structure of the yeast (HDAC) Rpd3L complex Descriptor: Histone deacetylase RPD3, Transcriptional regulatory protein DEP1, Transcriptional regulatory protein PHO23, ... Authors: Patel, A.B, Radhakrishnan, I, He, Y. Deposit date: 2023-02-22 Release date: 2023-07-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nat Commun, 14, 2023
5IKK	Structure of the histone deacetylase Clr3 Descriptor: 1,2-ETHANEDIOL, Histone deacetylase clr3, MAGNESIUM ION, ... Authors: Brugger, C, Schalch, T. Deposit date: 2016-03-03 Release date: 2016-04-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Mol.Cell, 62, 2016
6Z2K	The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex Descriptor: Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... Authors: Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. Deposit date: 2020-05-16 Release date: 2020-07-08 Last modified: 2020-10-07 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
6Z6F	HDAC-PC Descriptor: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... Authors: Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. Deposit date: 2020-05-28 Release date: 2021-02-17 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
6Z6O	HDAC-TC Descriptor: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... Authors: Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. Deposit date: 2020-05-28 Release date: 2021-02-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
6Z6H	HDAC-DC Descriptor: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... Authors: Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. Deposit date: 2020-05-28 Release date: 2021-02-17 Method: ELECTRON MICROSCOPY (8.55 Å) Cite: Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021

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