PDB: 252 resultsInfo pagesStatus searchChemie searchBIRD

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6TVN	Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase Descriptor: 5-bromanyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2020-01-10 Release date: 2020-11-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
6U3G	Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399) Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE Authors: Das, S, Lambright, D.G. Deposit date: 2019-08-21 Release date: 2019-09-25 Last modified: 2023-11-29 Method: ELECTRON MICROSCOPY (53 Å) Cite: Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure, 27, 2019
5C5B	Crystal Structure of Human APPL BAR-PH Heterodimer Descriptor: DCC-interacting protein 13-alpha, DCC-interacting protein 13-beta, GLYCEROL Authors: Chen, Y.J, Chen, B. Deposit date: 2015-06-19 Release date: 2016-06-22 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of Human APPL BAR-PH Heterodimer To Be Published
5L81	Crystal structure of the PH domain of murine kindlin-3 Descriptor: Fermitin family homolog 3, SODIUM ION Authors: Ni, T, Harlos, K, Gilbert, R.J.C. Deposit date: 2016-06-06 Release date: 2017-01-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. Biochem. J., 474, 2017
6YYK	Crystal Structure of 1,5-dimethylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: 1,5-dimethyl-3~{H}-indol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2020-05-05 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Optimising crystallographic systems for structure-guided drug discovery To Be Published
6YYF	Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: 5-chloranyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2020-05-05 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Optimising crystallographic systems for structure-guided drug discovery To Be Published
6YYG	Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: 5-(trifluoromethyloxy)-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2020-05-05 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Optimising crystallographic systems for structure-guided drug discovery To Be Published
1B55	PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, TYROSINE-PROTEIN KINASE BTK, ZINC ION Authors: Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A.M, Potter, B.V.L, O'Brien, R, Ladbury, J.E, Saraste, M. Deposit date: 1999-01-12 Release date: 1999-06-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BWN	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4 Descriptor: BRUTON'S TYROSINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ZINC ION Authors: Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A, Potter, B, Saraste, M. Deposit date: 1998-09-25 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BTK	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT R28C Descriptor: BRUTON'S TYROSINE KINASE, SODIUM ION, ZINC ION Authors: Hyvonen, M, Saraste, M. Deposit date: 1997-07-01 Release date: 1997-09-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J., 16, 1997
4XH3	Mechanistic insights into anchorage of the contractile ring from yeast to humans Descriptor: Actin-binding protein anillin Authors: Sun, L.F, Guan, R.F, Chen, Z.C. Deposit date: 2015-01-04 Release date: 2015-07-15 Last modified: 2022-03-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
4Y94	Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate Descriptor: INOSITOL HEXAKISPHOSPHATE, Non-specific protein-tyrosine kinase, ZINC ION Authors: Wang, Q, Kuriyan, J. Deposit date: 2015-02-16 Release date: 2015-03-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
4Y93	Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) Descriptor: 4-tert-butyl-N-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide, CALCIUM ION, Non-specific protein-tyrosine kinase,Non-specific protein-tyrosine kinase, ... Authors: Wang, Q, Kuriyan, J. Deposit date: 2015-02-16 Release date: 2015-03-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.695 Å) Cite: Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
8S93	Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... Authors: Lin, D.Y, Andreotti, A.H. Deposit date: 2023-03-27 Release date: 2023-08-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
5A3F	Crystal structure of the dynamin tetramer Descriptor: DYNAMIN 3 Authors: Reubold, T.F, Faelber, K, Plattner, N, Posor, Y, Branz, K, Curth, U, Schlegel, J, Anand, R, Manstein, D.J, Noe, F, Haucke, V, Daumke, O, Eschenburg, S. Deposit date: 2015-05-29 Release date: 2015-08-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Crystal Structure of the Dynamin Tetramer Nature, 525, 2015
5H3D	Helical structure of membrane tubules decorated by ACAP1 (BARPH doamin) protein by cryo-electron microscopy and MD simulation Descriptor: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Authors: Chan, C, Pang, X.Y, Zhang, Y, Sun, F, Fan, J. Deposit date: 2016-10-22 Release date: 2019-01-16 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (14 Å) Cite: ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages. Plos Comput.Biol., 15, 2019
7AX3	CryoEM structure of the super-constricted two-start dynamin 1 filament Descriptor: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER Authors: Liu, J.W, Zhang, P.J. Deposit date: 2020-11-09 Release date: 2021-11-10 Method: ELECTRON MICROSCOPY (3.74 Å) Cite: CryoEM structure of the super-constricted two-start dynamin 1 filament. Nat Commun, 12, 2021
6OLU	RIAM RA-PH core structure in the P212121 space group Descriptor: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Authors: Wu, J. Deposit date: 2019-04-17 Release date: 2020-04-22 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Structure, 29, 2021
6O6H	RIAM cc-RA-PH structure in the P21212 space group Descriptor: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Authors: Wu, J. Deposit date: 2019-03-06 Release date: 2020-09-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure, 2020
7C3M	Structure of FERM protein Descriptor: Fermitin family homolog 3,Fermitin family homolog 3,Fermitin family homolog 3 Authors: Bu, W, Loh, Z.Y, Jin, S, Basu, S, Ero, R, Park, J.E, Yan, X, Wang, M, Sze, S.K, Tan, S.M, Gao, Y.G. Deposit date: 2020-05-13 Release date: 2020-06-03 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. Plos Biol., 18, 2020
6TT2	The PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: MAGNESIUM ION, Tyrosine-protein kinase BTK, ZINC ION Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2019-12-23 Release date: 2020-11-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
5JJD	crystal structure of the ceramide transfer protein PH and START domain complex Descriptor: Collagen type IV alpha-3-binding protein, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL Authors: Prashek, J, Bouyain, S, Yao, X. Deposit date: 2016-04-23 Release date: 2017-07-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.403 Å) Cite: Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. J. Biol. Chem., 292, 2017
6TSE	Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2019-12-20 Release date: 2020-11-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
6TUH	The PH domain of Bruton's tyrosine kinase mutant R28C Descriptor: 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... Authors: Brear, P, Wagstaff, J, Hyvonen, M. Deposit date: 2020-01-07 Release date: 2020-11-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published
6U3E	Best fitting antiparallel model for Volume 1 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399) Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE Authors: Das, S, Lambright, D.G. Deposit date: 2019-08-21 Release date: 2019-09-25 Last modified: 2023-11-29 Method: ELECTRON MICROSCOPY (53 Å) Cite: Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes. Structure, 27, 2019

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