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3AV6	Crystal structure of mouse DNA methyltransferase 1 with AdoMet Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYLMETHIONINE, ZINC ION Authors: Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. Deposit date: 2011-02-22 Release date: 2011-05-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
4FSX	crystal structure of Se-substituted Zea mays ZMET2 in complex with SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FT4	crystal structure of Zea mays ZMET2 in complex H3(1-32)K9me2 peptide and SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, H3(1-32)K9me2 peptide, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FT2	crystal structure of Zea mays ZMET2 in complex H3(1-15)K9me2 peptide and SAH Descriptor: DNA (cytosine-5)-methyltransferase 1, H3 peptide, S-ADENOSYL-L-HOMOCYSTEINE Authors: Du, J, Patel, D.J. Deposit date: 2012-06-27 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
3PT6	Crystal structure of mouse DNMT1(650-1602) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PTA	Crystal structure of human DNMT1(646-1600) in complex with DNA Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PT9	Crystal structure of mouse DNMT1(731-1602) in the free state Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Song, J, Patel, D.J. Deposit date: 2010-12-02 Release date: 2010-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
7SFD	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A Descriptor: (2S)-2-({3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl}sulfanyl)-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFE	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830334A Descriptor: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]amino}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFF	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B Descriptor: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-[4-(trifluoromethyl)phenyl]acetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFC	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A Descriptor: 1,2-ETHANEDIOL, DNA (12-MER), DNA (cytosine-5)-methyltransferase 1, ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFG	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Cofactor SAM Descriptor: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 1, DNA Strand 1, ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7T02	Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM Descriptor: DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ... Authors: Wang, J, Patel, D.J. Deposit date: 2021-11-29 Release date: 2022-02-23 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7UBU	Crystal structure of ZMET2 in complex with hemimethylated CAG DNA and a histone H3Kc9me2 peptide Descriptor: 5MC SSDNA, C49 SSDNA, DNA (cytosine-5)-methyltransferase 1, ... Authors: Fang, J, Song, J. Deposit date: 2022-03-15 Release date: 2022-06-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun, 13, 2022
6W8V	Crystal structure of mouse DNMT1 in complex with ACG DNA Descriptor: ACG DNA (5'-D(*AP*CP*TP*TP*AP*(C49)P*GP*GP*AP*AP*GP*G)-3'), ACG DNA (5'-D(*CP*CP*TP*TP*CP*(5CM)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-21 Release date: 2020-07-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.12 Å) Cite: DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6W8W	Crystal structure of mouse DNMT1 in complex with CCG DNA Descriptor: CCG DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), CCG DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-21 Release date: 2020-07-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6PA7	The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. Descriptor: CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ... Authors: Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A. Deposit date: 2019-06-11 Release date: 2020-06-17 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586, 2020

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