PDB: 277 resultsInfo pagesStatus searchChemie searchBIRD

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7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-18 Release date: 2022-08-03 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
6UTY	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Old" crystal soaked with CTP for 30 minutes) Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.15 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
5UH8	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2017-01-11 Release date: 2017-04-12 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.176 Å) Cite: Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
7W5Y	Cryo-EM structure of SoxS-dependent transcription activation complex with fpr promoter DNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y. Deposit date: 2021-11-30 Release date: 2022-10-26 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. Nucleic Acids Res., 50, 2022
7F75	Cryo-EM structure of Spx-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-06-28 Release date: 2021-10-13 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
7BEG	Structures of class I bacterial transcription complexes Descriptor: Class I pacrA promoter non-template DNA, Class I pacrA promoter template DNA, DNA-directed RNA polymerase subunit alpha, ... Authors: Ye, F.Z, Hao, M, Zhang, X.D. Deposit date: 2020-12-23 Release date: 2021-12-01 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
6EYD	Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Kouba, T, Barvik, I, Krasny, L. Deposit date: 2017-11-11 Release date: 2018-12-12 Last modified: 2020-05-06 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
5IPM	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2016-06-22 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
4JKR	Crystal Structure of E. coli RNA Polymerase in complex with ppGpp Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, Wang, Y, Steitz, T.A. Deposit date: 2013-03-11 Release date: 2013-05-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.2 Å) Cite: The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol.Cell, 50, 2013
6UU6	E. coli sigma-S transcription initiation complex with a 4-nt RNA and a UTP ("Old" crystal soaked with UTP, ddCTP, and dinucleotide ApG for 30 minutes) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
4JK2	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4ZH2	Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.204 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
7C17	The cryo-EM structure of E. coli CueR transcription activation complex with fully duplex promoter DNA Descriptor: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Fang, C.L, Zhang, Y. Deposit date: 2020-05-02 Release date: 2020-09-30 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.22 Å) Cite: CueR activates transcription through a DNA distortion mechanism. Nat.Chem.Biol., 17, 2021
6C9Y	Cryo-EM structure of E. coli RNAP sigma70 holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S. Deposit date: 2018-01-29 Release date: 2018-02-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.25 Å) Cite: Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
5UHB	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with Rifampin Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2017-01-11 Release date: 2017-04-12 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.29 Å) Cite: Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
6PB6	The E. coli class-II CAP-dependent transcription activation complex at the state 2 Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W. Deposit date: 2019-06-13 Release date: 2020-03-18 Last modified: 2021-10-20 Method: ELECTRON MICROSCOPY (4.29 Å) Cite: Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020
5VSW	X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-05-12 Release date: 2017-06-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (4.295 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
4XLR	Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA Descriptor: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-13 Release date: 2015-09-23 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.3 Å) Cite: CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
6UU4	E. coli sigma-S transcription initiation complex with a 3-nt RNA ("old" crystal soaked with GTP and dinucleotide GpA for 30 minutes) Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.305 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
5UHF	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-IX336 Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2017-01-11 Release date: 2017-04-12 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.345 Å) Cite: Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
6PB4	The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at the state 2 Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W. Deposit date: 2019-06-13 Release date: 2020-03-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.35 Å) Cite: Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
7Q4U	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme octamer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-02 Release date: 2022-11-16 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (4.39 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
6UU8	E. coli mutant sigma-S transcription initiation complex with a 7-nt RNA ("Fresh" mutant crystal soaked with GTP, UTP, and CTP for 30 minutes) Descriptor: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.4 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UU7	E. coli sigma-S transcription initiation complex with a 6-nt RNA and an NTP ("Old" crystal soaked with UTP, CTP, ddGTP, and dinucleotide ApG for 30 minutes) Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, De, S, Steitz, T.A. Deposit date: 2019-10-30 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.4 Å) Cite: Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020

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