6GWC
| Tubulin:iE5 alphaRep complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALPHA-TUBULIN, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Gigant, B, Campanacci, V. | Deposit date: | 2018-06-22 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Selection and Characterization of Artificial Proteins Targeting the Tubulin alpha Subunit. Structure, 27, 2019
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6GJ4
| Tubulin-6j complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(quinolin-5-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate, CALCIUM ION, ... | Authors: | Brindisi, M, Ulivieri, C, Alfano, G, Gemma, S, Balaguer, F.d.A, Khan, T, Grillo, A, Chemi, G, Menchon, G, Prota, A.E, Olieric, N, Agell, D.L, Barasoain, I, Diaz, J.F, Nebbioso, A, Conte, M.R, Lopresti, L, Magnano, S, Amet, R, Kinsella, P, Zisterer, D.M, Ibrahim, O, O'Sullivan, J, Morbidelli, L, Spaccapelo, R, Baldari, C, Butini, S, Novellino, E, Campiani, G, Altucci, L, Steinmetz, M.O, Brogi, S. | Deposit date: | 2018-05-16 | Release date: | 2018-12-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. Eur J Med Chem, 162, 2018
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6GVN
| Tubulin:TM-3 DARPin complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Gigant, B, Cantos Fernandes, S, Campanacci, V. | Deposit date: | 2018-06-21 | Release date: | 2019-04-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Insight into microtubule nucleation from tubulin-capping proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GWD
| Tubulin:iiH5 alphaRep complex | Descriptor: | ALPHA-TUBULIN, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Gigant, B, Campanacci, V. | Deposit date: | 2018-06-22 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Selection and Characterization of Artificial Proteins Targeting the Tubulin alpha Subunit. Structure, 27, 2019
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6GVM
| Tubulin:F3II DARPin complex | Descriptor: | F3II DARPIN, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Gigant, B, Campanacci, V, Cantos Fernandes, S. | Deposit date: | 2018-06-21 | Release date: | 2019-04-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Insight into microtubule nucleation from tubulin-capping proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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7LVR
| KIF14[391-743] - ADP-AlFx closed state class in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2021-02-26 | Release date: | 2021-05-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6GZE
| Tubulin-GDP.BeF complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, ... | Authors: | Oliva, M.A, Diaz, J.F. | Deposit date: | 2018-07-04 | Release date: | 2020-01-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural model for differential cap maturation at growing microtubule ends. Elife, 9, 2020
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7LVQ
| KIF14[391-743] - AMP-PNP closed state class in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2021-02-26 | Release date: | 2021-05-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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7M2Y
| Closed conformation of the Yeast wild-type gamma-TuRC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2X
| Open conformation of the Yeast wild-type gamma-TuRC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2Z
| Monomeric single-particle reconstruction of the Yeast gamma-TuSC | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Spindle pole body component SPC97, Spindle pole body component SPC98, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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7M2W
| Engineered disulfide cross-linked closed conformation of the Yeast gamma-TuRC(SS) | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Spindle pole body component 110, Spindle pole body component SPC97, ... | Authors: | Brilot, A.F, Lyon, A.S, Zelter, A, Viswanath, S, Maxwell, A, MacCoss, M.J, Muller, E.G, Sali, A, Davis, T.N, Agard, D.A. | Deposit date: | 2021-03-17 | Release date: | 2021-05-12 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | CM1-driven assembly and activation of yeast gamma-tubulin small complex underlies microtubule nucleation. Elife, 10, 2021
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6H9B
| 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation | Descriptor: | 9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Varela, P.F, Gigant, B. | Deposit date: | 2018-08-03 | Release date: | 2018-12-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. J. Med. Chem., 62, 2019
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7M18
| HeLa-tubulin in complex with cryptophycin 1 | Descriptor: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-12 | Release date: | 2021-09-08 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7LXB
| HeLa-tubulin in complex with cryptophycin 52 | Descriptor: | Cryptophycin 52, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-03 | Release date: | 2021-09-08 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7M20
| 18-mer HeLa-tubulin rings in complex with Cryptophycin 1 | Descriptor: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-15 | Release date: | 2021-09-08 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7LZ8
| Tubulin-RB3_SLD-TTL in complex with compound 5t | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)pyrido[3,2-d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | Authors: | White, S.W, Yun, M. | Deposit date: | 2021-03-09 | Release date: | 2021-09-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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7LZ7
| Tubulin-RB3_SLD-TTL in complex with compound 5k | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | Authors: | White, S.W, Yun, M. | Deposit date: | 2021-03-09 | Release date: | 2021-09-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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7MIZ
| Atomic structure of cortical microtubule from Toxoplasma gondii | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wang, X, Brown, A, Sibley, L.D, Zhang, R. | Deposit date: | 2021-04-18 | Release date: | 2021-06-02 | Last modified: | 2021-06-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins. Nat Commun, 12, 2021
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7N32
| protofilaments of microtubule doublets bound to outer-arm dynein | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Rao, Q, Zhang, K. | Deposit date: | 2021-05-31 | Release date: | 2021-09-29 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism. Nat.Struct.Mol.Biol., 28, 2021
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7MWG
| 16-nm repeat microtubule doublet | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Rao, Q, Zhang, K. | Deposit date: | 2021-05-17 | Release date: | 2021-09-29 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism. Nat.Struct.Mol.Biol., 28, 2021
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7N61
| structure of C2 projections and MIPs | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FAP147, FAP178, ... | Authors: | Han, L, Zhang, K. | Deposit date: | 2021-06-07 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022
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7NB8
| Plasmodium falciparum kinesin-5 motor domain without nucleotide, complexed with 14 protofilament microtubule. | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-5, MAGNESIUM ION, ... | Authors: | Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A. | Deposit date: | 2021-01-25 | Release date: | 2021-10-13 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. J.Biol.Chem., 297, 2021
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7NBA
| Plasmodium falciparum kinesin-5 motor domain bound to AMPPNP, complexed with 14 protofilament microtubule. | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin motor domain-containing protein,Kinesin motor domain-containing protein, MAGNESIUM ION, ... | Authors: | Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A. | Deposit date: | 2021-01-25 | Release date: | 2021-10-13 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. J.Biol.Chem., 297, 2021
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7NVN
| Human TRiC complex in closed state with nanobody and tubulin bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
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