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7SL7	Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R) Descriptor: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ... Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STH	Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STI	Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STJ	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STK	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7U6E	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ... Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7V3P	Cryo-EM structure of the IGF1R/insulin complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... Authors: Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. Deposit date: 2021-08-11 Release date: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of the IGF1R/insulin complex To Be Published
7WRQ	Structure of Human IGF1/IGFBP3/ALS Ternary Complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... Authors: Kim, H, Fu, Y, Kim, H.M. Deposit date: 2022-01-27 Release date: 2022-08-10 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
7YRR	Cryo-EM structure of IGF1R with two IGF1 complex Descriptor: Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I Authors: Xi, Z, Cang, W. Deposit date: 2022-08-10 Release date: 2023-08-16 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution To Be Published
7Z5L	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO) Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ... Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, C. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7Z5Q	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP) Descriptor: Insulin, Insulin A chain, SULFATE ION Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
8CLS	Drosophila melanogaster insulin receptor ectodomain in complex with DILP5 Descriptor: Insulin-like receptor, Probable insulin-like peptide 5, Probable insulin-like peptide 5 A chain Authors: Viola, C.M, Brzozowski, A.M, Shafi, T. Deposit date: 2023-02-17 Release date: 2023-12-20 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans. Nat Commun, 14, 2023
8EYR	Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I Authors: Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. Deposit date: 2022-10-28 Release date: 2022-11-09 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
8EYX	Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 Descriptor: Insulin, Insulin receptor Authors: Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. Deposit date: 2022-10-29 Release date: 2022-11-09 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
8EYY	Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 Descriptor: Insulin, Insulin receptor Authors: Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. Deposit date: 2022-10-29 Release date: 2022-11-09 Last modified: 2022-12-07 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
8EZ0	Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation Descriptor: Insulin, Insulin receptor Authors: Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. Deposit date: 2022-10-29 Release date: 2022-11-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
8GSG	T3R3 form of Human insulin with single Zn Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Zhu, Z.L. Deposit date: 2022-09-06 Release date: 2023-03-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.05 Å) Cite: T3R3 insulin with single Zn To Be Published
8HGZ	Crystal structure of insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: DeMirci, H, Ayan, E. Deposit date: 2022-11-16 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions Crystals, 13, 2023
8HSF	Insulin triple mutant INS-RQD Descriptor: Insulin A chain, Insulin B chain Authors: Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Insulin triple mutant INS-RQD To Be Published
8HSK	Insulin single mutant INS-Q Descriptor: Insulin A chain, Insulin B chain, SULFATE ION Authors: Rao, S.S, Kundapura, S.V, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Insulin single mutant INS-Q To Be Published
8IPZ	Crystal structure of insulin detemir Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: DeMirci, H, Ayan, E. Deposit date: 2023-03-15 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of insulin detemir To Be Published
8ONI	Human insulin in complex with the analytical antibody S1 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... Authors: Johansson, E. Deposit date: 2023-04-03 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
8ONK	Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Descriptor: Heavy chain of analytical antibody HUI-001 Fab, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... Authors: Johansson, E. Deposit date: 2023-04-03 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (3.403 Å) Cite: Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
8PI4	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in dimer (T2) conformation Descriptor: Insulin B chain,Insulin A chain Authors: Johansson, E, Schluckebier, G. Deposit date: 2023-06-21 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PI5	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in hexamer (T3R3) conformation Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, RESORCINOL, ... Authors: Johansson, E, Schluckebier, G. Deposit date: 2023-06-21 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024

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