PDB: 395 resultsInfo pagesStatus searchChemie searchBIRD

---

7OPB	IL7R in complex with an antagonist Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ... Authors: Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N. Deposit date: 2021-05-31 Release date: 2022-05-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.144 Å) Cite: Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
7PG0	Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1 Descriptor: Insulin, Isoform Short of Insulin receptor Authors: Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. Deposit date: 2021-08-12 Release date: 2022-02-02 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (7.6 Å) Cite: Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG2	Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1 Descriptor: Insulin, Isoform Short of Insulin receptor Authors: Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. Deposit date: 2021-08-12 Release date: 2022-02-02 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (6.7 Å) Cite: Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG3	Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2 Descriptor: Insulin, Isoform Short of Insulin receptor Authors: Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. Deposit date: 2021-08-12 Release date: 2022-02-02 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (7.3 Å) Cite: Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG4	Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3 Descriptor: Insulin, Isoform Short of Insulin receptor Authors: Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. Deposit date: 2021-08-12 Release date: 2022-02-02 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (9.1 Å) Cite: Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7QID	tentative model of the human insulin receptor ectodomain bound by three insulin Descriptor: Insulin, Insulin receptor, Isoform Short of Insulin receptor Authors: Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. Deposit date: 2021-12-14 Release date: 2022-02-02 Method: ELECTRON MICROSCOPY (5 Å) Cite: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain J Cell Biol, 219, 2020
7S0Q	Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-08-30 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7S7K	Crystal structure of the EphB2 extracellular domain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, ... Authors: Xu, Y, Xu, K, Nikolov, D.B. Deposit date: 2021-09-16 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.15 Å) Cite: The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. Int J Mol Sci, 22, 2021
7S8V	Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-09-20 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7SL1	Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E) Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL2	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL3	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL4	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL6	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL7	Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R) Descriptor: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ... Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STH	Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STI	Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STJ	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STK	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7U08	Structure of CD148 fibronectin type III domain 1 and 2 Descriptor: PLATINUM (II) ION, Receptor-type tyrosine-protein phosphatase eta Authors: Zhou, D, Zhu, J. Deposit date: 2022-02-17 Release date: 2023-02-22 Method: X-RAY DIFFRACTION (3.30691743 Å) Cite: Structure of CD148 fibronectin type III domain 1 and 2 To Be Published
7U23	Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-02-22 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun, 13, 2022
7U6D	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459 Descriptor: IM459, Isoform Short of Insulin receptor Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (5.03 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U6E	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ... Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U7N	IL-27 quaternary receptor signaling complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... Authors: Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. Deposit date: 2022-03-07 Release date: 2022-05-25 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
7V3P	Cryo-EM structure of the IGF1R/insulin complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... Authors: Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. Deposit date: 2021-08-11 Release date: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structure of the IGF1R/insulin complex To Be Published

<678910111213141516>