PDB: 116 resultsInfo pagesStatus searchChemie searchBIRD

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2L5U	Structure of the first PHD finger (PHD1) from CHD4 (Mi2b) Descriptor: Chromodomain-helicase-DNA-binding protein 4, ZINC ION Authors: Mansfield, R.E, Kwan, A.H, Mackay, J.P. Deposit date: 2010-11-08 Release date: 2011-01-19 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9 J.Biol.Chem., 286, 2011
2OX0	Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9 Descriptor: CHLORIDE ION, JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, ... Authors: Pilka, E.S, Ng, S.S, Kavanagh, K.L, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2007-02-19 Release date: 2007-03-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448, 2007
2MJ8	Solution structure of CDYL2 chromodomain Descriptor: Chromodomain Y-like protein 2 Authors: Qin, S, Houliston, S, Arrowsmith, C.H, Edwards, A.M, Wu, H, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2013-12-28 Release date: 2014-04-23 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
5F3E	Crystal structure of human KDM4A in complex with compound 54a Descriptor: 8-[4-[2-[4-(4-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.16 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F37	Crystal structure of human KDM4A in complex with compound 58 Descriptor: 1,2-ETHANEDIOL, 3H-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.22 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5A	Crystal Structure of human JMJD2D complexed with KDOAM16 Descriptor: 1,2-ETHANEDIOL, 2-[(furan-2-ylmethylamino)methyl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4D, ... Authors: Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-12-04 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.41 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F2W	Crystal structure of human KDM4A in complex with compound 16 Descriptor: 1,2-ETHANEDIOL, 2-(2-azanyl-1,3-thiazol-4-yl)pyridine-4-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F39	Crystal structure of human KDM4A in complex with compound 37 Descriptor: 8-(1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Lysine-specific demethylase 4A, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.65 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F32	Crystal structure of human KDM4A in complex with compound 40 Descriptor: 1,2-ETHANEDIOL, 8-(2-azanyl-1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F2S	Crystal structure of human KDM4A in complex with compound 15 Descriptor: 1,2-ETHANEDIOL, 2-(2-azanyl-1,3-thiazol-4-yl)pyridine-4-carboxylic acid, CHLORIDE ION, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.08 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3C	Crystal structure of human KDM4A in complex with compound 52d Descriptor: 8-[4-[2-[(4-fluorophenyl)methyl-methyl-amino]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.06 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5I	Crystal Structure of human JMJD2A complexed with KDOOA011340 Descriptor: 2-[[(phenylmethyl)amino]methyl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... Authors: Krojer, T, Vollmar, M, Crawley, L, Szykowska, A, Gileadi, C, Johansson, C, England, K, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-12-04 Release date: 2015-12-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.63 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3G	Crystal structure of human KDM4A in complex with compound 53a Descriptor: 8-[4-[2-[4-[(4-chlorophenyl)methyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5FPL	Crystal structure of human JARID1B in complex with CCT363901 Descriptor: 1,2-ETHANEDIOL, 8-[4-(2-azanylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... Authors: Srikannathasan, V, Yann-Vai, L.B, Nowak, R, Johansson, C, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Huber, K, Oppermann, U. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.35 Å) Cite: 8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives as Potent, Cell Permeable, Kdm4 (Jmjd2) and Kdm5 (Jarid1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3I	Crystal structure of human KDM4A in complex with compound 54j Descriptor: 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. Deposit date: 2015-12-02 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.24 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5C	Crystal Structure of human JMJD2D complexed with KDOPP7 Descriptor: 1,2-ETHANEDIOL, 8-[[(phenylmethyl)amino]methyl]-1~{H}-pyrido[3,4-d]pyrimidin-4-one, Lysine-specific demethylase 4D, ... Authors: Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-12-04 Release date: 2015-12-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016

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