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6OUF	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.358 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTK	Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.123 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTQ	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.467 Å) Cite: Carbonic Anhydrase II complexed with benzene sulfonamide MB9-561B To Be Published
3TVN	Human Carbonic Anhydrase II Proton Transfer Mutant Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Mikulski, R.L, West, D.M, Sippel, K.H, Avvaru, B.S, Chingkuang, T, McKenna, R. Deposit date: 2011-09-20 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.497 Å) Cite: Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013
6OUH	Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.449 Å) Cite: Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A To Be Published
1JV0	THE CRYSTAL STRUCTURE OF THE ZINC(II) ADDUCT OF THE CAI MICHIGAN 1 VARIANT Descriptor: 1,2-ETHANEDIOL, CARBONIC ANHYDRASE I, CHLORIDE ION, ... Authors: Briganti, F, Ferraroni, M, Chegwidden, W.R, Scozzafava, A, Supuran, C.T, Tilli, S. Deposit date: 2001-08-28 Release date: 2001-09-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination Biochemistry, 41, 2002
6OUB	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B Descriptor: 4-{[(2-hydroxyethyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.418 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-694B To Be Published
6OUE	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.415 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-707A To Be Published
6ODZ	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
3U3A	structure of Human Carbonic Anhydrase II V143I Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION Authors: West, D, Mckenna, R. Deposit date: 2011-10-05 Release date: 2012-10-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.549 Å) Cite: Structural Analysis of Human Carbonic Anhydrase II Binding Pocket To be Published
6OTI	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTM	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.307 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTP	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUI	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.528 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB11-710A To Be Published
6OTO	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B Descriptor: 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.496 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUJ	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A Descriptor: 3-[(1S)-1-(4-nitrophenyl)ethyl]-2-oxo-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A To Be Published
3U7C	crystal structure of the V143I mutant of human carbonic anhydrase II Descriptor: BICARBONATE ION, CARBON DIOXIDE, Carbonic anhydrase 2, ... Authors: West, D.M, Kim, C.U, Robbins, A.H, Mckenna, R. Deposit date: 2011-10-13 Release date: 2013-02-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (0.93 Å) Cite: crystal structure of the V143I mutant of human carbonic anhydrase II To be Published
6PDV	Cu-Carbonic Anhydrase II, A Nitrite Reductase Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (II) ION, Carbonic anhydrase 2, ... Authors: Andring, J.T, McKenna, R. Deposit date: 2019-06-19 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Iucrj, 7, 2020
7Y2E	Zn-Carbonic Anhydrase II complexed with 3NPA after UV at 120 K Descriptor: 3-NITROTOLUENE, Carbonic anhydrase 2, ZINC ION Authors: Kim, C.U, Kim, J.K. Deposit date: 2022-06-09 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Temperature series of human Carbonic Anhydrase II with photolysis of caged CO2 To Be Published
6PGX	Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity Descriptor: 4-[(2S)-2-hydroxy-3-{[(2R)-2-hydroxy-3-(4-sulfamoylphenoxy)propyl]tellanyl}propoxy]benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-06-25 Release date: 2019-08-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. Eur.J.Med.Chem., 181, 2019
3V2M	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Aggarwal, M, McKenna, A. Deposit date: 2011-12-12 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.471 Å) Cite: Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II To be Published
1KEQ	Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole Descriptor: 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ... Authors: Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W. Deposit date: 2001-11-16 Release date: 2002-03-06 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry, 41, 2002
3UYN	HCA 3 Descriptor: Carbonic anhydrase 3, ZINC ION Authors: Fisher, Z, McKenna, R. Deposit date: 2011-12-06 Release date: 2012-02-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins, 68, 2007
3V3J	Kinetic and structural studies of thermostabilized mutants of HCA II. Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Boone, C.D, Fisher, S.Z, McKenna, R. Deposit date: 2011-12-13 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
1KOP	NEISSERIA GONORRHOEAE CARBONIC ANHYDRASE Descriptor: AZIDE ION, BETA-MERCAPTOETHANOL, CARBONIC ANHYDRASE, ... Authors: Huang, S, Xue, Y, Chirica, L, Lindskog, S, Jonsson, B.-H. Deposit date: 1998-03-22 Release date: 1998-12-09 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide. J.Mol.Biol., 283, 1998

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