PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Human jak1 kinase domain in complex with inhibitor
Descriptor:	1,2-ETHANEDIOL, 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile, Tyrosine-protein kinase JAK1
Authors:	Read, J.A, Steuber, H.
Deposit date:	2019-08-21
Release date:	2020-04-29
Last modified:	2020-05-27
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020

Human jak1 kinase domain in complex with inhibitor
Descriptor:	Tyrosine-protein kinase JAK1, ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide
Authors:	Read, J.A, Steuber, H.
Deposit date:	2019-08-21
Release date:	2020-04-29
Last modified:	2020-05-27
Method:	X-RAY DIFFRACTION (2.04 Å)
Cite:	Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020