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6NF5	BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP1 fragment antigen binding heavy chain, ... Authors: Ozorowski, G, Torres, J.L, Steichen, J.M, Schief, W.R, Ward, A.B. Deposit date: 2018-12-18 Release date: 2019-11-06 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.71 Å) Cite: A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
6V8Z	VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure Descriptor: 10-1074 Fab Heavy Chain, 10-1074 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Henderson, R, Acharya, P. Deposit date: 2019-12-12 Release date: 2020-02-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nat Commun, 11, 2020
6NM6	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ... Authors: Lai, Y.-T, Kwong, P.D. Deposit date: 2019-01-10 Release date: 2019-02-27 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.739 Å) Cite: Improvement of antibody functionality by structure-guided paratope engraftment. Nat Commun, 10, 2019
6UTK	Crystal structure of 438-B11 Fab in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 at 3.80 Angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kumar, S, Wilson, I.A. Deposit date: 2019-10-29 Release date: 2020-09-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.8 Å) Cite: A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite Sci Adv, 6, 2020
6V0R	BG505 SOSIP.664 Trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Nogal, B, Cottrell, C.A, Ward, A.B. Deposit date: 2019-11-19 Release date: 2020-04-01 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.87 Å) Cite: Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines. Cell Rep, 30, 2020
6V8X	VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Henderson, R, Acharya, P. Deposit date: 2019-12-12 Release date: 2020-02-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nat Commun, 11, 2020
6V6W	Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Fab Heavy chain, ... Authors: Kumar, S, Wilson, I.A. Deposit date: 2019-12-06 Release date: 2020-09-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (6.5 Å) Cite: A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite Sci Adv, 6, 2020
6VI0	Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 gp120, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2020-01-10 Release date: 2021-01-13 Last modified: 2021-08-25 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention. Mabs, 13
6OKP	B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 Descriptor: 10-1074 Heavy Chain,10-1074 Heavy Chain, 10-1074 Light Chain,10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barnes, C.O, Bjorkman, P.J. Deposit date: 2019-04-14 Release date: 2019-06-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity, 50, 2019
6VPX	Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 Fabs Descriptor: (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Rantalainen, K, Ward, A.B.W. Deposit date: 2020-02-04 Release date: 2020-04-22 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5 Å) Cite: HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. Cell Rep, 31, 2020
6OPA	Crystal structure of bovine Fab NC-Cow1 in complex with HIV-1 BG505 SOSIP.664, and human Fabs 35022 and PGT128 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... Authors: Stanfield, R.L, Wilson, I.A. Deposit date: 2019-04-24 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.084 Å) Cite: Structural basis of broad HIV neutralization by a vaccine-induced cow antibody. Sci Adv, 6, 2020
6VLR	BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIPv5.2 gp41, ... Authors: Cottrell, C.A, Ward, A.B. Deposit date: 2020-01-24 Release date: 2020-06-24 Last modified: 2020-09-16 Method: ELECTRON MICROSCOPY (4.42 Å) Cite: Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
6VO1	BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Cottrell, C.A, Ward, A.B. Deposit date: 2020-01-29 Release date: 2020-07-01 Last modified: 2020-09-16 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
6ORN	Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074 Descriptor: 10-1074 antibody Fab heavy chain, 10-1074 antibody Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. Deposit date: 2019-04-30 Release date: 2019-06-12 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.05 Å) Cite: Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
6VN0	BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... Authors: Cottrell, C.A, Shin, M, Ward, A.B. Deposit date: 2020-01-29 Release date: 2020-06-24 Last modified: 2020-09-16 Method: ELECTRON MICROSCOPY (4.25 Å) Cite: Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
6ORO	Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab874NHP antibody Fab heavy chain, ... Authors: Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. Deposit date: 2019-04-30 Release date: 2019-06-12 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
6VZI	Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ... Authors: Lai, Y.-T, Kwong, P.D. Deposit date: 2020-02-28 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.716 Å) Cite: Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses. J.Virol., 94, 2020
6ORQ	Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab275MUR antibody Fab heavy chain, ... Authors: Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. Deposit date: 2019-04-30 Release date: 2019-06-12 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
6OHY	Chimpanzee SIV Env trimeric ectodomain. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Pallesen, J, Andrabi, R, de Val, N, Burton, D.R, Ward, A.B. Deposit date: 2019-04-08 Release date: 2019-06-05 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell Rep, 27, 2019
6VO0	BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 43A2 heavy chain, ... Authors: Nogal, B, Cottrell, C.A, Ward, A.B. Deposit date: 2020-01-29 Release date: 2020-07-01 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite. Sci Adv, 6, 2020
6OT1	Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 Descriptor: 0PV-b.01 heavy, 0PV-b.01 light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2019-05-02 Release date: 2019-08-07 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
6ORP	Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab897NHP antibody Fab heavy chain, ... Authors: Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. Deposit date: 2019-04-30 Release date: 2019-06-12 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
6OSY	Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 Descriptor: 0PV-a.01 Heavy, 0PV-a.01 Light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2019-05-02 Release date: 2019-07-24 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
6VKN	BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Cottrell, C.A, Ward, A.B. Deposit date: 2020-01-21 Release date: 2020-08-12 Last modified: 2020-09-02 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020
6VTT	Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2020-02-13 Release date: 2020-04-08 Last modified: 2021-10-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition. Cell Rep, 31, 2020

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