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PDB: 237 results

7BW6
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BU of 7bw6 by Molmil
Varicella-zoster virus capsid
Descriptor: Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ...
Authors:Wang, P.Y, Qi, J.X, Liu, C.C, Sun, J.Q.
Deposit date:2020-04-13
Release date:2020-09-23
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the varicella-zoster virus A-capsid.
Nat Commun, 11, 2020
4XRU
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BU of 4xru by Molmil
Structure of Pnkp1/Rnl/Hen1 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Wang, P.
Deposit date:2015-01-21
Release date:2015-04-22
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex.
Nat Commun, 6, 2015
5K7U
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BU of 5k7u by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
Descriptor: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYLMETHIONINE
Authors:Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7M
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BU of 5k7m by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex
Descriptor: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14
Authors:Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7W
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BU of 5k7w by Molmil
Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH
Descriptor: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:2016-05-26
Release date:2016-07-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
4RPP
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BU of 4rpp by Molmil
crystal structure of PKM2-K422R mutant bound with FBP
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, Pyruvate kinase PKM
Authors:Wang, P, Sun, C, Zhu, T, Xu, Y.
Deposit date:2014-10-31
Release date:2015-02-25
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015
8FMO
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BU of 8fmo by Molmil
Complex structure of K210 deletion Troponin complex with risedronate
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMR
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BU of 8fmr by Molmil
Complex structure of K210 deletion Troponin complex with ibandronate
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.238 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMQ
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BU of 8fmq by Molmil
Complex structure of K210 deletion Troponin complex with alendronate
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.248 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMN
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BU of 8fmn by Molmil
Complex structure of K210 deletion Troponin complex
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-23
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMT
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BU of 8fmt by Molmil
Complex structure of TnnT-R205L Troponin complex
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMS
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BU of 8fms by Molmil
Complex structure of K210 deletion Troponin complex with neridronate
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.435 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMP
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BU of 8fmp by Molmil
Complex structure of K210 deletion Troponin complex with pamidronate
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-24
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
8FMM
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BU of 8fmm by Molmil
Complex structure of wild type Troponin complex
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Wang, P, Ahmed, M, Sadek, H.
Deposit date:2022-12-23
Release date:2024-01-31
Method:X-RAY DIFFRACTION (3.112 Å)
Cite:Structural and Phenotypic Correction of K210del Genetic Cardiomyopathy by an FDA Approved drug
To Be Published
6A67
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BU of 6a67 by Molmil
Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody FLD21.140
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLD21.140 Heavy Chain, FLD21.140 Light Chain, ...
Authors:Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X.
Deposit date:2018-06-26
Release date:2018-08-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies.
J. Biol. Chem., 293, 2018
7VP9
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BU of 7vp9 by Molmil
Crystal structure of human ClpP in complex with ZG111
Descriptor: (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ...
Authors:Wang, P.Y, Gan, J.H, Yang, C.-G.
Deposit date:2021-10-15
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.552 Å)
Cite:Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.
Cell Chem Biol, 29, 2022
6IUV
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BU of 6iuv by Molmil
Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3C11 Heavy Chain, 3C11 Light Chain, ...
Authors:Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
6CKU
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BU of 6cku by Molmil
Solution structure of the zebrafish granulin AaE
Descriptor: Granulin-AaE
Authors:Wang, P, Ni, F.
Deposit date:2018-02-28
Release date:2018-06-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities.
Protein Sci., 27, 2018
6IUT
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BU of 6iut by Molmil
Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AVFluIgG01 Heavy Chain, ...
Authors:Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X.
Deposit date:2018-11-30
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
J. Biol. Chem., 294, 2019
8WDK
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BU of 8wdk by Molmil
The complex structure of Cul2-VCB-Protac-Wee1
Descriptor: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ...
Authors:Wang, P, Zhang, T.T.
Deposit date:2023-09-15
Release date:2024-09-18
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structure of Cul2-VCB-Protac-Wee1 complex at 3.6 Angstrom resolution.
To Be Published
5U2L
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BU of 5u2l by Molmil
Crystal structure of the Hsp104 N-terminal domain from Candida albicans
Descriptor: Heat shock protein 104
Authors:Wang, P, Li, J, Sha, B.
Deposit date:2016-11-30
Release date:2017-04-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.6555 Å)
Cite:Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.
Acta Crystallogr D Struct Biol, 73, 2017
5V1D
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BU of 5v1d by Molmil
Complex structure of the bovine PERK luminal domain and its substrate peptide
Descriptor: 12-mer peptide, eIF2AK3 protein
Authors:Wang, P, Li, J, Sha, B.
Deposit date:2017-03-02
Release date:2018-02-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization
J. Biol. Chem., 293, 2018
5U2U
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BU of 5u2u by Molmil
Crystal structure of the Hsp104 N-terminal domain from Saccharomyces cerevisiae
Descriptor: Heat shock protein 104
Authors:Wang, P, Li, J, Sha, B.
Deposit date:2016-11-30
Release date:2017-04-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.
Acta Crystallogr D Struct Biol, 73, 2017
8I7X
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BU of 8i7x by Molmil
Crystal structure of human ClpP in complex with ZG36
Descriptor: (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-[(4-methoxynaphthalen-1-yl)methyl]-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial
Authors:Wang, P.Y, Gan, J.H, Yang, C.-G.
Deposit date:2023-02-02
Release date:2023-07-19
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.
Eur.J.Med.Chem., 258, 2023
8WU0
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BU of 8wu0 by Molmil
Crystal structure of lisargine
Descriptor: CHLORIDE ION, Insulin, ZINC ION
Authors:Wang, P, Zhu, Z.
Deposit date:2023-10-19
Release date:2024-10-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:crystal structure of lisargine
To Be Published

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