2L98
 
 | | Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C | | Descriptor: | CALCIUM ION, RESVERATROL, Troponin C, ... | | Authors: | Sykes, B.D, Pineda-Sanabria, S.E, Robertson, I.M. | | Deposit date: | 2011-02-02 | | Release date: | 2011-03-30 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure of trans-Resveratrol in Complex with the Cardiac Regulatory Protein Troponin C.
Biochemistry, 50, 2011
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5W88
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7UH9
 | | NMR structure of the cNTnC-cTnI chimera bound to W8 | | Descriptor: | CALCIUM ION, N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide, Troponin C, ... | | Authors: | Cai, F, Kampourakis, T, Cockburn, K.T, Sykes, B.D. | | Deposit date: | 2022-03-26 | | Release date: | 2022-06-15 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7.
Acs Chem.Biol., 17, 2022
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3CTN
 | | STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES | | Descriptor: | CALCIUM ION, TROPONIN C | | Authors: | Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D. | | Deposit date: | 1997-05-08 | | Release date: | 1998-05-13 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
J.Biol.Chem., 272, 1997
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1N4I
 | | Solution structure of spruce budworm antifreeze protein at 5 degrees celsius | | Descriptor: | thermal hysteresis protein | | Authors: | Graether, S.P, Gagne, S.M, Spyracopoulos, L, Jia, Z, Davies, P.L, Sykes, B.D. | | Deposit date: | 2002-10-31 | | Release date: | 2003-04-08 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Spruce Budworm Antifreeze Protein: Changes in Structure and Dynamics at Low Temperature
J.Mol.Biol., 327, 2003
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2SDF
 | | SOLUTION NMR STRUCTURE OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1), 30 STRUCTURES | | Descriptor: | STROMAL CELL-DERIVED FACTOR-1 | | Authors: | Crump, M.P, Rajarathnam, K, Clark-Lewis, I, Sykes, B.D. | | Deposit date: | 1998-03-07 | | Release date: | 1998-06-17 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.
EMBO J., 16, 1997
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1ZAC
 | | N-DOMAIN OF TROPONIN C FROM CHICKEN SKELETAL MUSCLE, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | TROPONIN-C | | Authors: | Tsuda, S, Miura, A, Gagne, S.M, Spyracopoulos, L, Sykes, B.D. | | Deposit date: | 1998-04-07 | | Release date: | 1998-11-11 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C.
Biochemistry, 38, 1999
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1Y4E
 | | NMR structure of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger | | Descriptor: | Sodium/hydrogen exchanger 1 | | Authors: | Slepkov, E.R, Rainey, J.K, Li, X, Liu, Y, Lindhout, D.A, Sykes, B.D, Fliegel, L. | | Deposit date: | 2004-11-30 | | Release date: | 2005-02-01 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger.
J.Biol.Chem., 280, 2005
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7JGI
 | | NMR structure of the cNTnC-cTnI chimera bound to A7 | | Descriptor: | 7-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}heptanoic acid, CALCIUM ION, Troponin C, ... | | Authors: | Cai, F, Robertson, I.M, Kampourakis, T, Klein, B.A, Sykes, B.D. | | Deposit date: | 2020-07-19 | | Release date: | 2020-09-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers.
Acs Chem.Biol., 15, 2020
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7KAA
 | | NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex | | Descriptor: | 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol, CALCIUM ION, Troponin C, ... | | Authors: | Mercier, P, Li, M.X, Hartman, J.J, Sykes, B.D. | | Deposit date: | 2020-09-30 | | Release date: | 2021-03-24 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.
J.Med.Chem., 64, 2021
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6MV3
 | | NMR structure of the cNTnC-cTnI chimera bound to calcium desensitizer W7 | | Descriptor: | CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, Troponin C, ... | | Authors: | Cai, F, Hwang, P.M, Sykes, B.D. | | Deposit date: | 2018-10-24 | | Release date: | 2018-11-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Changes Induced by the Binding of the Calcium Desensitizer W7 to Cardiac Troponin.
Biochemistry, 57, 2018
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2CTN
 | | STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES | | Descriptor: | CALCIUM ION, TROPONIN C | | Authors: | Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D. | | Deposit date: | 1997-05-06 | | Release date: | 1998-05-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
J.Biol.Chem., 272, 1997
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2EOT
 | | SOLUTION STRUCTURE OF EOTAXIN, AN ENSEMBLE OF 32 NMR SOLUTION STRUCTURES | | Descriptor: | EOTAXIN | | Authors: | Crump, M.P, Rajarathnam, K, Kim, K.-S, Clark-Lewis, I, Sykes, B.D. | | Deposit date: | 1998-06-29 | | Release date: | 1998-11-11 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.
J.Biol.Chem., 273, 1998
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1HFN
 | | NMR solution structures of vMIP-II 1-71 from Kaposi's sarcoma-associated herpesvirus. | | Descriptor: | VIRAL MACROPHAGE INFLAMMATORY PROTEIN-II | | Authors: | Crump, M.P, Elisseeva, E, Gong, J.-H, Clark-Lewis, I, Sykes, B.D. | | Deposit date: | 2000-12-07 | | Release date: | 2001-01-07 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Structure/Function of Human Herpesvirus-8 Mip-II (1-71) and the Antagonist N-Terminal Segment (1-10)
FEBS Lett., 489, 2001
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1HFG
 | | NMR solution structure of vMIP-II 1-71 from Kaposi's sarcoma-associated herpesvirus (minimized average structure). | | Descriptor: | VIRAL MACROPHAGE INFLAMMATORY PROTEIN-II | | Authors: | Crump, M.P, Elisseeva, E, Gong, J.-H, Clark-Lewis, I, Sykes, B.D. | | Deposit date: | 2000-12-01 | | Release date: | 2001-01-07 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Structure/Function of Human Herpesvirus-8 Mip-II (1-71) and the Antagonist N-Terminal Segment (1-10)
FEBS Lett., 489, 2001
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1HFF
 | | NMR solution structures of the vMIP-II 1-10 peptide from Kaposi's sarcoma-associated herpesvirus. | | Descriptor: | VIRAL MACROPHAGE INFLAMMATORY PROTEIN-II | | Authors: | Crump, M.P, Elisseeva, E, Gong, J.H, Clark-Lewis, I, Sykes, B.D. | | Deposit date: | 2000-12-01 | | Release date: | 2000-12-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure/Function of Human Herpesvirus-8 Mip-II (1-71) and the Antagonist N-Terminal Segment (1-10)
FEBS Lett., 489, 2001
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7UHA
 | | NMR structure of the cNTnC-cTnI chimera bound to W6 | | Descriptor: | CALCIUM ION, N-(5-aminopentyl)-5-chloronaphthalene-1-sulfonamide, Troponin C, ... | | Authors: | Cai, F, Kampourakis, T, Cockburn, K.T, Sykes, B.D. | | Deposit date: | 2022-03-26 | | Release date: | 2022-06-15 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7.
Acs Chem.Biol., 17, 2022
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1HPW
 | | STRUCTURE OF A PILIN MONOMER FROM PSEUDOMONAS AERUGINOSA: IMPLICATIONS FOR THE ASSEMBLY OF PILI. | | Descriptor: | FIMBRIAL PROTEIN | | Authors: | Keizer, D.W, Slupsky, C.M, Campbell, A.P, Irvin, R.T, Sykes, B.D. | | Deposit date: | 2000-12-13 | | Release date: | 2001-05-02 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structure of a pilin monomer from Pseudomonas aeruginosa: implications for the assembly of pili.
J.Biol.Chem., 276, 2001
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1MSH
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1MXL
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1TNX
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1TNW
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2AFP
 | | THE SOLUTION STRUCTURE OF TYPE II ANTIFREEZE PROTEIN REVEALS A NEW MEMBER OF THE LECTIN FAMILY | | Descriptor: | PROTEIN (SEA RAVEN TYPE II ANTIFREEZE PROTEIN) | | Authors: | Gronwald, W, Loewen, M.C, Lix, B, Daugulis, A.J, Sonnichsen, F.D, Davies, P.L, Sykes, B.D. | | Deposit date: | 1998-12-14 | | Release date: | 1998-12-23 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The solution structure of type II antifreeze protein reveals a new member of the lectin family.
Biochemistry, 37, 1998
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2A93
 | | NMR SOLUTION STRUCTURE OF THE C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER, 40 STRUCTURES | | Descriptor: | C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER | | Authors: | Lavigne, P, Crump, M.P, Gagne, S.M, Hodges, R.S, Kay, C.M, Sykes, B.D. | | Deposit date: | 1998-06-09 | | Release date: | 1999-01-27 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.
J.Mol.Biol., 281, 1998
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1KDF
 | | NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | ANTIFREEZE PROTEIN | | Authors: | Sonnichsen, F.D, Deluca, C.I, Davies, P.L, Sykes, B.D. | | Deposit date: | 1996-07-08 | | Release date: | 1997-04-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction.
Structure, 4, 1996
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