3TY9
 
 | | Crystal Structure of C. Thermocellum PNKP Ligase Domain AMP-Adenylate | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, ... | | Authors: | Smith, P, Wang, L, Shuman, S. | | Deposit date: | 2011-09-24 | | Release date: | 2012-01-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FIN
 | | Crystal Structure of EttA (formerly YjjK) - an E. coli ABC-type ATPase | | Descriptor: | CITRIC ACID, EttA (YjjK) ABCF family protein, GLYCEROL, ... | | Authors: | Smith, P, Yuan, Y, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2012-06-09 | | Release date: | 2013-07-03 | | Last modified: | 2014-03-05 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.
Nat.Struct.Mol.Biol., 21, 2014
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3TY8
 | | Crystal Structure of C. Thermocellum PNKP Ligase Domain Apo Form | | Descriptor: | D(-)-TARTARIC ACID, GLYCEROL, Polynucleotide 2',3'-cyclic phosphate phosphodiesterase / polynucleotide 5'-hydroxyl-kinase / polynucleotide 3'-phosphatase | | Authors: | Smith, P, Wang, L, Shuman, S. | | Deposit date: | 2011-09-23 | | Release date: | 2012-01-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1F35
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6S54
 | | Transaminase from Pseudomonas fluorescens | | Descriptor: | Aspartate aminotransferase family protein, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Smith, P, Roura Padrosa, D, Lopez-Gallego, F, Paradisi, F, Dreveny, I. | | Deposit date: | 2019-06-30 | | Release date: | 2019-11-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Enhancing PLP-Binding Capacity of Class-III omega-Transaminase by Single Residue Substitution.
Front Bioeng Biotechnol, 7, 2019
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3HF1
 | | Crystal structure of human p53R2 | | Descriptor: | FE (III) ION, Ribonucleoside-diphosphate reductase subunit M2 B, SULFATE ION | | Authors: | Smith, P, Zhou, B, Yuan, Y.-C, Su, L, Tsai, S.-C, Yen, Y. | | Deposit date: | 2009-05-10 | | Release date: | 2009-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | 2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .
Biochemistry, 48, 2009
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1JOD
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3TY5
 | | Crystal Structure of C. thermocellum PNKP Ligase domain in complex with ATP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Polynucleotide 2',3'-cyclic phosphate phosphodiesterase / polynucleotide 5'-hydroxyl-kinase / polynucleotide 3'-phosphatase, ... | | Authors: | Smith, P, Wang, L, Shuman, S. | | Deposit date: | 2011-09-23 | | Release date: | 2012-01-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4KYY
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3P43
 | | Structure and Activities of Archaeal Members of the LigD 3' Phosphoesterase DNA Repair Enzyme Superfamily | | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, PHOSPHATE ION, ... | | Authors: | Smith, P, Nair, P.A, Das, U, Shuman, S. | | Deposit date: | 2010-10-05 | | Release date: | 2011-01-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily.
Nucleic Acids Res., 39, 2011
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1JOB
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3P4H
 | | Structures of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily | | Descriptor: | ATP-dependent DNA ligase, N-terminal domain protein, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Smith, P, Nair, P.A, Das, U, Zhu, H, Shuman, S. | | Deposit date: | 2010-10-06 | | Release date: | 2011-01-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily.
Nucleic Acids Res., 39, 2011
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3BGY
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1L2T
 | | Dimeric Structure of MJ0796, a Bacterial ABC Transporter Cassette | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Hypothetical ABC transporter ATP-binding protein MJ0796, ISOPROPYL ALCOHOL, ... | | Authors: | Smith, P.C, Karpowich, N, Rosen, J, Hunt, J.F. | | Deposit date: | 2002-02-24 | | Release date: | 2002-07-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.
Mol.Cell, 10, 2002
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4W7S
 | | Crystal structure of the yeast DEAD-box splicing factor Prp28 at 2.54 Angstroms resolution | | Descriptor: | GLYCEROL, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ... | | Authors: | Jacewicz, A, Smith, P, Schwer, B, Shuman, S. | | Deposit date: | 2014-08-22 | | Release date: | 2014-10-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.542 Å) | | Cite: | Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28.
Nucleic Acids Res., 42, 2014
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5FQT
 | | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 4. | | Descriptor: | (E)-3-[4-(6-hydroxy-2-isobutyl-5-methyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR ALPHA | | Authors: | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | | Deposit date: | 2015-12-14 | | Release date: | 2016-02-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
Acs Med.Chem.Lett., 7, 2016
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5FQP
 | | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 1. | | Descriptor: | (E)-3-[4-[(1R,3R)-6-hydroxy-2-isobutyl-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR ALPHA | | Authors: | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | | Deposit date: | 2015-12-14 | | Release date: | 2016-02-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
Acs Med.Chem.Lett., 7, 2016
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3TUT
 | | Crystal structure of RtcA.ATP binary complex | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | | Authors: | Chakravarty, A.K, Smith, P, Shuman, S. | | Deposit date: | 2011-09-18 | | Release date: | 2011-12-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3KGD
 | | Crystal structure of E. coli RNA 3' cyclase | | Descriptor: | ADENOSINE MONOPHOSPHATE, GLYCEROL, RNA 3'-terminal phosphate cyclase, ... | | Authors: | Shuman, S, Tanaka, N, Smith, P. | | Deposit date: | 2009-10-28 | | Release date: | 2010-04-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer.
Structure, 18, 2010
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1N4A
 | | The Ligand Bound Structure of E.coli BtuF, the Periplasmic Binding Protein for Vitamin B12 | | Descriptor: | CYANOCOBALAMIN, Vitamin B12 transport protein btuF | | Authors: | Karpowich, N.K, Smith, P.C, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2002-10-30 | | Release date: | 2003-03-11 | | Last modified: | 2021-08-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding.
J.Biol.Chem., 278, 2003
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1MZH
 | | QR15, an Aldolase | | Descriptor: | Deoxyribose-phosphate aldolase, PHOSPHATE ION | | Authors: | Tan, A.Y, Smith, P.C, Shen, J, Xiao, R, Acton, T, Rost, B, Montelione, G, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2002-10-07 | | Release date: | 2003-02-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Aquifex Aeolicus Aldolase,
Northeast Structural Genomics Consortium Target
QR15
To be Published
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1N4D
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2QY2
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4WAN
 | | Crystal structure of Msl5 protein in complex with RNA at 1.8 A | | Descriptor: | ACETATE ION, Branchpoint-bridging protein, GLYCEROL, ... | | Authors: | Jacewicz, A, Smith, P, Chico, L, Schwer, B, Shuman, S. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs.
Rna, 21, 2015
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4WAL
 | | Crystal structure of selenomethionine Msl5 protein in complex with RNA at 2.2 A | | Descriptor: | Branchpoint-bridging protein, CHLORIDE ION, GLYCEROL, ... | | Authors: | Jacewicz, A, Smith, P, Chico, L, Schwer, B, Shuman, S. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs.
Rna, 21, 2015
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