1K4Q
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![BU of 1k4q by Molmil](/molmil-images/mine/1k4q) | Human Glutathione Reductase Inactivated by Peroxynitrite | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | Deposit date: | 2001-10-08 | Release date: | 2002-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J.Biol.Chem., 277, 2002
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1ETE
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![BU of 1ete by Molmil](/molmil-images/mine/1ete) | |
1NLY
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![BU of 1nly by Molmil](/molmil-images/mine/1nly) | Crystal structure of the traffic ATPase of the Helicobacter pylori type IV secretion system in complex with ATPgammaS | Descriptor: | MAGNESIUM ION, NONAETHYLENE GLYCOL, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-01-08 | Release date: | 2003-05-06 | Last modified: | 2012-03-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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7OX6
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![BU of 7ox6 by Molmil](/molmil-images/mine/7ox6) | Solution structure of human interleukin-9 | Descriptor: | Interleukin-9 | Authors: | Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T. | Deposit date: | 2021-06-22 | Release date: | 2022-12-28 | Last modified: | 2023-01-11 | Method: | SOLUTION NMR | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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1SRU
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![BU of 1sru by Molmil](/molmil-images/mine/1sru) | Crystal structure of full length E. coli SSB protein | Descriptor: | Single-strand binding protein | Authors: | Savvides, S.N, Raghunathan, S, Fuetterer, K, Kozlov, A.G, Lohman, T.M, Waksman, G. | Deposit date: | 2004-03-23 | Release date: | 2004-08-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Sci., 13, 2004
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1OPX
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![BU of 1opx by Molmil](/molmil-images/mine/1opx) | Crystal structure of the traffic ATPase (HP0525) of the Helicobacter pylori type IV secretion system bound by sulfate | Descriptor: | NONAETHYLENE GLYCOL, SULFATE ION, virB11 homolog | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-03-06 | Release date: | 2003-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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1NLZ
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![BU of 1nlz by Molmil](/molmil-images/mine/1nlz) | Crystal structure of unliganded traffic ATPase of the type IV secretion system of helicobacter pylori | Descriptor: | virB11 homolog | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-01-08 | Release date: | 2003-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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2I9V
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![BU of 2i9v by Molmil](/molmil-images/mine/2i9v) | |
1XAN
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![BU of 1xan by Molmil](/molmil-images/mine/1xan) | |
2GQ8
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![BU of 2gq8 by Molmil](/molmil-images/mine/2gq8) | Structure of SYE1, an OYE homologue from S. ondeidensis, in complex with p-hydroxyacetophenone | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLAVIN MONONUCLEOTIDE, P-HYDROXYACETOPHENONE, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2GOU
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![BU of 2gou by Molmil](/molmil-images/mine/2gou) | Structure of wild type, oxidized SYE1, an OYE homologue from S. oneidensis | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-14 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2GQA
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![BU of 2gqa by Molmil](/molmil-images/mine/2gqa) | Structure of NADH-reduced SYE1, an OYE homologue from S. oneidensis | Descriptor: | FLAVIN MONONUCLEOTIDE, SULFATE ION, oxidoreductase, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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2GQ9
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![BU of 2gq9 by Molmil](/molmil-images/mine/2gq9) | Structure of SYE1, an OYE homologue from S. oneidensis, in complex with p-hydroxybenzaldehyde | Descriptor: | FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE, SULFATE ION, ... | Authors: | Savvides, S.N, van den Hemel, D. | Deposit date: | 2006-04-20 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding. J.Biol.Chem., 281, 2006
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6E4L
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![BU of 6e4l by Molmil](/molmil-images/mine/6e4l) | The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9 | Descriptor: | 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ... | Authors: | Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E. | Deposit date: | 2018-07-17 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat.Chem.Biol., 15, 2019
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8C7L
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![BU of 8c7l by Molmil](/molmil-images/mine/8c7l) | |
8C7E
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![BU of 8c7e by Molmil](/molmil-images/mine/8c7e) | |
3UCE
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![BU of 3uce by Molmil](/molmil-images/mine/3uce) | Crystal structure of a small-chain dehydrogenase in complex with NADPH | Descriptor: | Dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Buysschaert, G, Verstraete, K, Savvides, S, Vergauwen, B. | Deposit date: | 2011-10-26 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference. Febs J., 280, 2013
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3LN7
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![BU of 3ln7 by Molmil](/molmil-images/mine/3ln7) | |
7NX2
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![BU of 7nx2 by Molmil](/molmil-images/mine/7nx2) | Unbound antigen-binding fragment (FAb) 324 | Descriptor: | FAb 324 Heavy Chain, FAb 324 Light Chain, SULFATE ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX4
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![BU of 7nx4 by Molmil](/molmil-images/mine/7nx4) | |
7NWZ
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![BU of 7nwz by Molmil](/molmil-images/mine/7nwz) | ALK:ALKAL2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK and LTK ligand 2, ALK tyrosine kinase receptor | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX3
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![BU of 7nx3 by Molmil](/molmil-images/mine/7nx3) | Crystal structure of ALK in complex with Fab324 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor, Fab324 HeavyChain, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX0
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![BU of 7nx0 by Molmil](/molmil-images/mine/7nx0) | LTK:ALKAL1 complex stabilized by a Nanobody | Descriptor: | ALK and LTK ligand 1, Leukocyte tyrosine kinase receptor, Nb3.16, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX1
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![BU of 7nx1 by Molmil](/molmil-images/mine/7nx1) | TG domain of LTK | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Leukocyte tyrosine kinase receptor, TERBIUM(III) ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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8C6Z
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![BU of 8c6z by Molmil](/molmil-images/mine/8c6z) | necrotic enteritis associated Clostridium p. chitinase F8UNI4 in complex with inhibitor bisdionin C | Descriptor: | 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), CADMIUM ION, COBALT (II) ION, ... | Authors: | Bloch, Y, Savvides, S.N. | Deposit date: | 2023-01-12 | Release date: | 2023-05-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Contribution and structural characterization of Chitinases to Clostridium perfringens Pathogenesis in Broilers To Be Published
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