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PDB: 8 results

5EEC
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BU of 5eec by Molmil
Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor
Descriptor: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, SULFATE ION
Authors:Nguyen, N.Q, van den Akker, F.
Deposit date:2015-10-22
Release date:2016-02-03
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Antimicrob.Agents Chemother., 60, 2016
4ZBE
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Crystal structure of KPC-2 beta-lactamase complexed with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC
Authors:Nguyen, N.Q, van den Akker, F.
Deposit date:2015-04-14
Release date:2016-01-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of Klebsiella beta-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.
Plos One, 10, 2015
6B1J
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Crystal structure KPC-2 beta-lactamase complexed with WCK 5107 by soaking
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, 1,2-ETHANEDIOL, CITRIC ACID, ...
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-18
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018
6B1F
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BU of 6b1f by Molmil
Crystal structure KPC-2 beta-lactamase complexed with WCK 4234 by soaking
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, 1,2-ETHANEDIOL, CITRIC ACID, ...
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-18
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018
6B1W
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BU of 6b1w by Molmil
Crystal structure KPC-2 beta-lactamase complexed with WCK 5107 by co-crystallization
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, CHLORIDE ION, Carbapenem-hydrolyzing beta-lactamase KPC, ...
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-19
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018
6B22
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BU of 6b22 by Molmil
Crystal structure OXA-24 beta-lactamase complexed with WCK 4234 by co-crystallization
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, Beta-lactamase, CHLORIDE ION
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-19
Release date:2018-08-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018
6B1Y
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BU of 6b1y by Molmil
Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by co-crystallization
Descriptor: (2S,5Z)-1-formyl-5-imino-N'-[(3R)-1-(sulfooxy)pyrrolidine-3-carbonyl]piperidine-2-carbohydrazide, CHLORIDE ION, Carbapenem-hydrolyzing beta-lactamase KPC, ...
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-19
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018
6B1X
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BU of 6b1x by Molmil
Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by soaking
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-pyrrolidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, 1,2-ETHANEDIOL, CITRIC ACID, ...
Authors:van den Akker, F, Nguyen, N.Q.
Deposit date:2017-09-19
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
J. Med. Chem., 61, 2018

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