1DEF
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2DEF
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6QRM
| HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates | Descriptor: | Apoptosis-inducing factor 3, CHLORIDE ION, COENZYME A, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-02-19 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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5JF2
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT002 | Descriptor: | (3R)-3-{3-[(4-fluorophenyl)methyl]-1,2,4-oxadiazol-5-yl}-N-hydroxyheptanamide, ACETATE ION, IMIDAZOLE, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T, Hamiche, K. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF0
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with tripeptide Met-Ala-Arg | Descriptor: | ACETATE ION, MET-ALA-ARG, NICKEL (II) ION, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF1
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with actinonin | Descriptor: | ACETATE ION, ACTINONIN, Peptide deformylase, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JEX
| Crystal structure of type 2 PDF from Streptococcus agalactiae, crystallized in imidazole buffer | Descriptor: | IMIDAZOLE, Peptide deformylase, ZINC ION | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF3
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT018 | Descriptor: | ACETATE ION, IMIDAZOLE, Peptide deformylase, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JEY
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5JF6
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor 6b (AB47) | Descriptor: | 2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide, ACETATE ION, Peptide deformylase, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T, Hamiche, K. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF4
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT019 | Descriptor: | (3R)-3-{3-[(1-benzofuran-3-yl)methyl]-1,2,4-oxadiazol-5-yl}-4-cyclopentyl-N-hydroxybutanamide, ACETATE ION, IMIDAZOLE, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF5
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT020 | Descriptor: | (3R)-3-{3-[(2H-1,3-benzodioxol-5-yl)methyl]-1,2,4-oxadiazol-5-yl}-4-cyclopentyl-N-hydroxybutanamide, ACETATE ION, IMIDAZOLE, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JEZ
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with tripeptide Met-Ala-Ser | Descriptor: | ACETATE ION, Met-Ala-Ser, Peptide deformylase, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF7
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor SMP289 | Descriptor: | 2-(3-benzyl-5-bromo-1H-indol-1-yl)-N-hydroxyacetamide, ACETATE ION, IMIDAZOLE, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T, Hamiche, K. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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5JF8
| Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor RAS358 (21) | Descriptor: | ACETATE ION, IMIDAZOLE, Peptide deformylase, ... | Authors: | Fieulaine, S, Giglione, C, Meinnel, T. | Deposit date: | 2016-04-19 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep, 6, 2016
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4JE6
| Crystal structure of a human-like mitochondrial peptide deformylase | Descriptor: | Peptide deformylase 1A, chloroplastic/mitochondrial, ZINC ION | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | Deposit date: | 2013-02-26 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart. Acta Crystallogr.,Sect.D, 70, 2014
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4JE8
| Crystal structure of a human-like mitochondrial peptide deformylase in complex with Met-Ala-Ser | Descriptor: | Peptide deformylase 1A, chloroplastic/mitochondrial, ZINC ION, ... | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | Deposit date: | 2013-02-26 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart. Acta Crystallogr.,Sect.D, 70, 2014
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4JE7
| Crystal structure of a human-like mitochondrial peptide deformylase in complex with actinonin | Descriptor: | ACTINONIN, Peptide deformylase 1A, chloroplastic/mitochondrial, ... | Authors: | Fieulaine, S, Meinnel, T, Giglione, C. | Deposit date: | 2013-02-26 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart. Acta Crystallogr.,Sect.D, 70, 2014
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6SK2
| HsNMT1 in complex with both MyrCoA and Acetylated-GKSFSKPR peptide reveals N-terminal Lysine Myristoylation | Descriptor: | Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.90000653 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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6SKJ
| DeltaC2 C-terminal truncation of HsNMT1 in complex with MyrCoA and GNCFSKPR substrates | Descriptor: | Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-15 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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6SK8
| DeltaC3 C-terminal truncation of HsNMT1 in complex with MyrCoA and GDCFSKPR substrates | Descriptor: | Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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6SJZ
| HsNMT1 in complex with both MyrCoA and Acetylated-GNCFSKPR substrates | Descriptor: | Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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6SK3
| C-terminal HsNMT1 deltaC3 truncation in complex with both MyrCoA and GNCFSKPR substrates | Descriptor: | Apoptosis-inducing factor 3, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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7OWO
| HsNMT1 in complex with both MyrCoA and N-acetylated KSFSKPR peptide | Descriptor: | COENZYME A, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | Authors: | Dian, C, Giglione, C, Meinnel, T. | Deposit date: | 2021-06-18 | Release date: | 2022-12-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation. J.Mol.Biol., 434, 2022
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7OWN
| HsNMT1 in complex with both MyrCoA and peptide AKSFSKPR | Descriptor: | ALA-LYS-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | Authors: | Dian, C, Giglione, C, Meinnel, T. | Deposit date: | 2021-06-18 | Release date: | 2022-12-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation. J.Mol.Biol., 434, 2022
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