3C64
| The MC179 portion of the Cysteine-rich Interdomain Region (CIDR) of a Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP1) | Descriptor: | CHLORIDE ION, PfEMP1 variant 2 of strain MC, TETRAETHYLENE GLYCOL | Authors: | Klein, M.M, Gittis, A.G, Su, H.P, Makobongo, M.O, Moore, J.M, Singh, S, Miller, L.H, Garboczi, D.N. | Deposit date: | 2008-02-02 | Release date: | 2008-09-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure. Plos Pathog., 4, 2008
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1WU9
| Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1) | Descriptor: | Microtubule-associated protein RP/EB family member 1 | Authors: | Honnappa, S, John, C.M, Kostrewa, D, Winkler, F.K, Steinmetz, M.O. | Deposit date: | 2004-12-02 | Release date: | 2005-02-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural insights into the EB1-APC interaction Embo J., 24, 2005
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1FOU
| CONNECTOR PROTEIN FROM BACTERIOPHAGE PHI29 | Descriptor: | UPPER COLLAR PROTEIN | Authors: | Simpson, A.A, Tao, Y, Leiman, P.G, Badasso, M.O, He, Y, Jardine, P.J, Olson, N.H, Morais, M.C, Grimes, S.N, Anderson, D.L, Baker, T.S, Rossmann, M.G. | Deposit date: | 2000-08-28 | Release date: | 2000-12-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the bacteriophage phi29 DNA packaging motor. Nature, 408, 2000
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6QUS
| HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule | Descriptor: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | Deposit date: | 2019-02-28 | Release date: | 2019-11-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural determinants of microtubule minus end preference in CAMSAP CKK domains. Nat Commun, 10, 2019
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3TQ7
| EB1c/EB3c heterodimer in complex with the CAP-Gly domain of P150glued | Descriptor: | Dynactin subunit 1, Microtubule-associated protein RP/EB family member 1, Microtubule-associated protein RP/EB family member 3 | Authors: | De Groot, C.O, Scharer, M.A, Capitani, G, Steinmetz, M.O. | Deposit date: | 2011-09-09 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued). J.Struct.Biol., 177, 2012
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5J2U
| Tubulin-MMAF complex | Descriptor: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Waight, A.B, Bargsten, K, Doronina, S, Steinmetz, M.O, Sussman, D, Prota, A.E. | Deposit date: | 2016-03-30 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. Plos One, 11, 2016
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5FIS
| Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation | Descriptor: | EXD1, GADOLINIUM ATOM | Authors: | Yang, Z, Chen, K.M, Pandey, R.R, Homolka, D, Reuter, M, Rodino Janeiro, B.K, Sachidanandam, R, Fauvarque, M.O, McCarthy, A.A, Pillai, R.S. | Deposit date: | 2015-10-02 | Release date: | 2015-12-23 | Last modified: | 2016-01-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Piwi Slicing and Exd1 Drive Biogenesis of Nuclear Pirnas from Cytosolic Targets of the Mouse Pirna Pathway Mol.Cell, 61, 2016
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7PJF
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | Descriptor: | Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | Deposit date: | 2021-08-24 | Release date: | 2021-09-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.862 Å) | Cite: | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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7PJE
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | Descriptor: | Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | Deposit date: | 2021-08-24 | Release date: | 2021-09-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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8OY1
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1Z2B
| Tubulin-colchicine-vinblastine: stathmin-like domain complex | Descriptor: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Gigant, B, Wang, C, Ravelli, R.B.G, Roussi, F, Steinmetz, M.O, Curmi, P.A, Sobel, A, Knossow, M. | Deposit date: | 2005-03-08 | Release date: | 2005-05-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural basis for the regulation of tubulin by vinblastine. Nature, 435, 2005
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1FQ4
| CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2R)-1-{[(2S,3R,5R)-1-cyclohexyl-3-hydroxy-5-{[2-(morpholin-4-yl)ethyl]carbamoyl}oct-7-yn-2-yl]amino}-3-(methylsulfa nyl)-1-oxopropan-2-yl]-1H-benzimidazole-2-carboxamide, SACCHAROPEPSIN, ... | Authors: | Cronin, N.B, Badasso, M.O, Tickle, I.J, Dreyer, T, Hoover, D.J, Rosati, R.L, Humblet, C.C, Lunney, E.A, Cooper, J.B. | Deposit date: | 2000-09-03 | Release date: | 2000-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity. J.Mol.Biol., 303, 2000
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1FQ5
| X-ray structure of a cyclic statine inhibitor PD-129,541 bound to yeast proteinase A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(5S,9S,10S,13S)-9-hydroxy-5,10-bis(2-methylpropyl)-4,7,12,16-tetraoxo-3,6,11,17-tetraazabicyclo[17.3.1]tricosa-1(23),19,21-trien-13-yl]-3-(naphthalen-1-yl)-2-(naphthalen-1-ylmethyl)propanamide, SACCHAROPEPSIN, ... | Authors: | Cronin, N.B, Badasso, M.O, Tickle, I.J, Dreyer, T, Hoover, D.J, Rosati, R.L, Humblet, C.C, Lunney, E.A, Cooper, J.B. | Deposit date: | 2000-09-03 | Release date: | 2000-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity. J.Mol.Biol., 303, 2000
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5OSK
| Tubulin-7j complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(2,5-Dimethoxybenzyl)-7-sulfamoyloxy-6-methoxy-3,4-dihydroquinazolin-2(1H)-one, CALCIUM ION, ... | Authors: | Menchon, G, Prota, A.E, Steinmetz, M.O, Potter, B.V.L. | Deposit date: | 2017-08-17 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. J. Med. Chem., 61, 2018
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8C0F
| Tubulin-PTC596 complex | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-fluoranyl-2-(6-fluoranyl-2-methyl-benzimidazol-1-yl)-~{N}4-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine, ... | Authors: | Prota, A.E, Muehlethaler, T, Weetall, M, Steinmetz, M.O. | Deposit date: | 2022-12-16 | Release date: | 2022-12-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1005 Å) | Cite: | Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent Mol Cancer Ther, 20, 2021
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5OW5
| p60p80-CAMSAP complex | Descriptor: | 1,2-ETHANEDIOL, Calmodulin-regulated spectrin-associated protein, DI(HYDROXYETHYL)ETHER, ... | Authors: | Rezabkova, L, Capitani, G, Prota, A.E, Kammerer, R.A, Steinmetz, M.O. | Deposit date: | 2017-08-30 | Release date: | 2018-07-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex. Structure, 26, 2018
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6Y6D
| Tubulin-7-Aminonoscapine complex | Descriptor: | (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Oliva, M.A, Prota, A.E, Rodriguez-Salarichs, J, Gu, W, Bennani, Y.L, Jimenez-Barbero, J, Canales, A, Steinmetz, M.O, Diaz, J.F. | Deposit date: | 2020-02-26 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of Noscapine Activation for Tubulin Binding. J.Med.Chem., 63, 2020
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4X21
| The MAP kinase JNK3 as target for halogen bonding | Descriptor: | CHLORIDE ION, Mitogen-activated protein kinase 10, N-ethyl-4-{[4-(1H-indol-3-yl)-5-iodopyrimidin-2-yl]amino}piperidine-1-carboxamide | Authors: | Lange, A, Buettner, F.M, Guenther, M.B, Zimmermann, M.O, Hennig, S, Laufer, S.A, Stehle, T, Boeckler, F. | Deposit date: | 2014-11-25 | Release date: | 2015-11-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond. J.Am.Chem.Soc., 137, 2015
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2AKF
| Crystal structure of the coiled-coil domain of coronin 1 | Descriptor: | Coronin-1A, ZINC ION | Authors: | Kammerer, R.A, Kostrewa, D, Progias, P, Honnappa, S, Avila, D, Lustig, A, Winkler, F.K, Pieters, J, Steinmetz, M.O. | Deposit date: | 2005-08-03 | Release date: | 2005-09-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A conserved trimerization motif controls the topology of short coiled coils Proc.Natl.Acad.Sci.Usa, 102, 2005
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4C7M
| The crystal structure of TcpB or BtpA TIR domain | Descriptor: | Toll/interleukin-1 receptor domain-containing protein | Authors: | Alaidarous, M, Ve, T, Casey, L.W, Valkov, E, Ullah, M.O, Schembri, M.A, Mansell, A, Sweet, M.J, Kobe, B. | Deposit date: | 2013-09-23 | Release date: | 2013-12-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. J.Biol.Chem., 289, 2014
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4BSX
| Crystal Structure of the N terminal domain of TRIF (TIR-domain- containing adapter-inducing interferon-beta) | Descriptor: | TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 | Authors: | Ullah, M.O, Ve, T, Mangan, M, Alaidarous, M, Sweet, M.J, Mansell, A, Kobe, B. | Deposit date: | 2013-06-12 | Release date: | 2013-12-11 | Last modified: | 2013-12-18 | Method: | X-RAY DIFFRACTION (2.229 Å) | Cite: | The Tlr Signalling Adaptor Trif/Ticam-1 Has an N-Terminal Helical Domain with Structural Similarity to Ifit Proteins Acta Crystallogr.,Sect.D, 69, 2013
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4C0M
| Crystal Structure of the N terminal domain of wild type TRIF (TIR- domain-containing adapter-inducing interferon-beta) | Descriptor: | TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 | Authors: | Ullah, M.O, Ve, T, Mangan, M, Alaidarous, M, Sweet, M.J, Mansell, A, Kobe, B. | Deposit date: | 2013-08-05 | Release date: | 2013-12-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Tlr Signalling Adaptor Trif/Ticam-1 Has an N-Terminal Helical Domain with Structural Similarity to Ifit Proteins Acta Crystallogr.,Sect.D, 69, 2013
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8RIV
| T2R-TTL-1-K08 complex | Descriptor: | (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P. | Deposit date: | 2023-12-19 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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8RIW
| T2R-TTL-1-L01 complex | Descriptor: | (2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E.P, Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E. | Deposit date: | 2023-12-19 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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3GJP
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