1HUX
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![BU of 1hux by Molmil](/molmil-images/mine/1hux) | CRYSTAL STRUCTURE OF THE ACIDAMINOCOCCUS FERMENTANS (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE COMPONENT A | Descriptor: | ACTIVATOR OF (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE, ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER | Authors: | Locher, K.P, Hans, M, Yeh, A.P, Schmid, B, Buckel, W, Rees, D.C. | Deposit date: | 2001-01-04 | Release date: | 2001-03-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A. J.Mol.Biol., 307, 2001
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1BY5
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![BU of 1by5 by Molmil](/molmil-images/mine/1by5) | FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME | Descriptor: | FE (III) ION, FERRIC HYDROXAMATE UPTAKE PROTEIN, FERRICHROME, ... | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | Deposit date: | 1998-10-23 | Release date: | 1999-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell(Cambridge,Mass.), 95, 1998
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1BY3
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![BU of 1by3 by Molmil](/molmil-images/mine/1by3) | FHUA FROM E. COLI | Descriptor: | N-OCTYL-2-HYDROXYETHYL SULFOXIDE, PROTEIN (FERRICHROME-IRON RECEPTOR PRECURSOR (FHUA)) | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | Deposit date: | 1998-10-22 | Release date: | 1999-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell(Cambridge,Mass.), 95, 1998
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1L7V
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![BU of 1l7v by Molmil](/molmil-images/mine/1l7v) | Bacterial ABC Transporter Involved in B12 Uptake | Descriptor: | CYCLO-TETRAMETAVANADATE, VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC, Vitamin B12 transport ATP-binding protein btuD | Authors: | Locher, K.P, Lee, A.T, Rees, D.C. | Deposit date: | 2002-03-18 | Release date: | 2002-05-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science, 296, 2002
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3CFZ
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![BU of 3cfz by Molmil](/molmil-images/mine/3cfz) | |
2QI9
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![BU of 2qi9 by Molmil](/molmil-images/mine/2qi9) | ABC-transporter BtuCD in complex with its periplasmic binding protein BtuF | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | Authors: | Hvorup, R.N, Goetz, B.A, Niederer, M, Hollenstein, K, Perozo, E, Locher, K.P. | Deposit date: | 2007-07-03 | Release date: | 2007-08-14 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science, 317, 2007
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7O9W
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![BU of 7o9w by Molmil](/molmil-images/mine/7o9w) | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | Descriptor: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-04-17 | Release date: | 2022-01-12 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65, 2022
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1N2Z
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![BU of 1n2z by Molmil](/molmil-images/mine/1n2z) | 2.0 Angstrom structure of BtuF, the vitamin B12 binding protein of E. coli | Descriptor: | CADMIUM ION, CHLORIDE ION, CYANOCOBALAMIN, ... | Authors: | Borths, E.L, Locher, K.P, Lee, A.T, Rees, D.C. | Deposit date: | 2002-10-24 | Release date: | 2002-12-18 | Last modified: | 2021-08-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter Proc.Natl.Acad.Sci.USA, 99, 2002
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5OVW
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![BU of 5ovw by Molmil](/molmil-images/mine/5ovw) | Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli | Descriptor: | GLYCEROL, Nanobody, Vitamin B12-binding protein | Authors: | Mireku, S.A, Sauer, M.M, Glockshuber, R, Locher, K.P. | Deposit date: | 2017-08-30 | Release date: | 2017-11-08 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.653 Å) | Cite: | Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD. Sci Rep, 7, 2017
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7OCI
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![BU of 7oci by Molmil](/molmil-images/mine/7oci) | Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M. | Deposit date: | 2021-04-27 | Release date: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases. Glycobiology, 31, 2021
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6EJJ
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![BU of 6ejj by Molmil](/molmil-images/mine/6ejj) | Structure of a glycosyltransferase / state 2 | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, NerylNeryl pyrophosphate, ... | Authors: | Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P. | Deposit date: | 2017-09-21 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nat Commun, 9, 2018
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4FI3
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![BU of 4fi3 by Molmil](/molmil-images/mine/4fi3) | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | Authors: | Korkhov, V.M, Mireku, S.A, Locher, K.P. | Deposit date: | 2012-06-07 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.466 Å) | Cite: | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F. Nature, 490, 2012
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8RQF
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![BU of 8rqf by Molmil](/molmil-images/mine/8rqf) | Cryo-EM structure of human NTCP-Bulevirtide complex | Descriptor: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | Authors: | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | Deposit date: | 2024-01-18 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Cryo-EM structure of human NTCP-Bulevirtide complex To Be Published
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7PHQ
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![BU of 7phq by Molmil](/molmil-images/mine/7phq) | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-18 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (8.45 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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8PN9
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![BU of 8pn9 by Molmil](/molmil-images/mine/8pn9) | Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1 | Descriptor: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, ... | Authors: | Ramirez, A.S, Kowal, J, Locher, K.P. | Deposit date: | 2023-06-30 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B. Cell, 187, 2024
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7PIJ
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![BU of 7pij by Molmil](/molmil-images/mine/7pij) | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-20 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHP
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![BU of 7php by Molmil](/molmil-images/mine/7php) | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-18 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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4R9U
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![BU of 4r9u by Molmil](/molmil-images/mine/4r9u) | Structure of vitamin B12 transporter BtuCD in a nucleotide-bound outward facing state | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Korkhov, V.M, Mireku, S.A, Veprintsev, D.B, Locher, K.P. | Deposit date: | 2014-09-08 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.785 Å) | Cite: | Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F. Nat.Struct.Mol.Biol., 21, 2014
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4ZRQ
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![BU of 4zrq by Molmil](/molmil-images/mine/4zrq) | |
4ZRP
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![BU of 4zrp by Molmil](/molmil-images/mine/4zrp) | TC:CD320 | Descriptor: | CALCIUM ION, CD320 antigen, CYANOCOBALAMIN, ... | Authors: | Alam, A, Locher, K.P. | Deposit date: | 2015-05-12 | Release date: | 2016-07-20 | Last modified: | 2021-08-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of transcobalamin recognition by human CD320 receptor. Nat Commun, 7, 2016
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2HYD
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![BU of 2hyd by Molmil](/molmil-images/mine/2hyd) | Multidrug ABC transporter SAV1866 | Descriptor: | ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION | Authors: | Dawson, R.J.P, Locher, K.P. | Deposit date: | 2006-08-05 | Release date: | 2006-09-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of a bacterial multidrug ABC transporter. Nature, 443, 2006
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6QEX
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![BU of 6qex by Molmil](/molmil-images/mine/6qex) | |
7OZ1
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![BU of 7oz1 by Molmil](/molmil-images/mine/7oz1) | Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Skarda, L, Kowal, J, Locher, K.P. | Deposit date: | 2021-06-25 | Release date: | 2021-09-22 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the Human Cholesterol Transporter ABCG1. J.Mol.Biol., 433, 2021
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7QBG
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![BU of 7qbg by Molmil](/molmil-images/mine/7qbg) | TC:CD320 in complex with nanobody TC-Nb4 | Descriptor: | Anti-TC:CD320 nanobody TC-Nb4, CALCIUM ION, CD320 antigen, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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7QBE
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![BU of 7qbe by Molmil](/molmil-images/mine/7qbe) | TC:CD320 in complex with nanobody TC-Nb11 | Descriptor: | Anti-transcobalamin-2 nanobody TC-Nb11, CALCIUM ION, CD320 antigen, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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