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PDB: 373 results

3BLT
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BU of 3blt by Molmil
Crystal structures of YopH complexed with PVSN and PVS, inhibitors of YopH which co-valent bind to Cys of active site
Descriptor: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate
Authors:Liu, S, Zhang, Z.-Y.
Deposit date:2007-12-11
Release date:2009-02-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases.
J.Am.Chem.Soc., 130, 2008
6WVA
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BU of 6wva by Molmil
Takifugu rubripes VKOR-like with vitamin K1 epoxide at non-catalytic state
Descriptor: Vitamin K epoxide reductase-like protein, termini restrained by green fluorescent protein
Authors:Liu, S, Sukumar, N, Li, W.
Deposit date:2020-05-05
Release date:2021-03-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
Science, 371, 2021
5J95
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BU of 5j95 by Molmil
MAP4K4 in complex with inhibitor
Descriptor: 1-{4-[6-amino-5-(4-chlorophenyl)pyridin-3-yl]phenyl}cyclopentane-1-carboxylic acid, Mitogen-activated protein kinase kinase kinase kinase 4
Authors:Liu, S.
Deposit date:2016-04-08
Release date:2017-04-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:MAP4K4 in complex with inhibitor
To Be Published
7TD0
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BU of 7td0 by Molmil
Lysophosphatidic acid receptor 1-Gi complex bound to LPA
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
7TD2
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BU of 7td2 by Molmil
Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
7TD1
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BU of 7td1 by Molmil
Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
7TD4
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BU of 7td4 by Molmil
Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod
Descriptor: 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
7TD3
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BU of 7td3 by Molmil
Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022
2FYS
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BU of 2fys by Molmil
Crystal structure of Erk2 complex with KIM peptide derived from MKP3
Descriptor: Dual specificity protein phosphatase 6, Mitogen-activated protein kinase 1
Authors:Liu, S, Sun, J.P, Zhou, B, Zhang, Z.Y.
Deposit date:2006-02-08
Release date:2006-04-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3
Proc.Natl.Acad.Sci.Usa, 103, 2006
4NE9
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BU of 4ne9 by Molmil
PCSK9 in complex with LDLR peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ...
Authors:Liu, S.
Deposit date:2013-10-28
Release date:2014-09-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem.Biol., 21, 2014
4F2A
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BU of 4f2a by Molmil
Crystal structure of cholestryl esters transfer protein in complex with inhibitors
Descriptor: (2R)-3-{[4-(4-chloro-3-ethylphenoxy)pyrimidin-2-yl][3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}-1,1,1-trifluoropropan-2-ol, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHLORIDE ION, ...
Authors:Liu, S, Qiu, X.
Deposit date:2012-05-07
Release date:2012-09-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
J.Biol.Chem., 287, 2012
6LA7
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BU of 6la7 by Molmil
Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5
Descriptor: Beta-2-microglobulin, Capsid protein VP1, Capsid protein VP2, ...
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-12
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LBO
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BU of 6lbo by Molmil
Cryo-EM structure of echovirus 11 empty particle at pH 7.4
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-14
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LA3
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BU of 6la3 by Molmil
Cryo-EM structure of full echovirus 11 particle at pH 7.4
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-11
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LAO
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BU of 6lao by Molmil
Cryo-EM structure of echovirus 11 complexed with its attaching receptor CD55 at pH 5.5
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-12
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LBQ
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BU of 6lbq by Molmil
Cryo-EM structure of echovirus 11 empty particle at pH 5.5
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-14
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LA4
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BU of 6la4 by Molmil
Cryo-EM structure of full echovirus 11 particle at pH 5.5
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-11
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LA6
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BU of 6la6 by Molmil
Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4
Descriptor: Beta-2-microglobulin, Capsid protein VP1, Capsid protein VP2, ...
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-12
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
6LAP
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BU of 6lap by Molmil
Cryo-EM structure of echovirus 11 A-particle at pH 7.4
Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Liu, S, Gao, F.G.
Deposit date:2019-11-13
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Chin.Sci.Bull., 2020
4WHU
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BU of 4whu by Molmil
BROMO domain of CREB binding protein
Descriptor: 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, CREB-binding protein
Authors:Liu, S.
Deposit date:2014-09-23
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Direct photocapture of bromodomains using tropolone chemical probes
To Be Published
4TN6
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BU of 4tn6 by Molmil
CK1d in complex with inhibitor
Descriptor: 4-{4-(4-fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine, Casein kinase I isoform delta, SULFATE ION
Authors:Liu, S.
Deposit date:2014-06-03
Release date:2015-08-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:CK1D IN COMPLEX WITH inhibitor
To Be Published
5JQ1
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BU of 5jq1 by Molmil
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
Descriptor: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
Authors:Liu, S.
Deposit date:2016-05-04
Release date:2017-06-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
5JPV
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BU of 5jpv by Molmil
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic
Descriptor: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
Authors:Liu, S.
Deposit date:2016-05-04
Release date:2017-06-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
6M1K
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BU of 6m1k by Molmil
USP7 in complex with a novel inhibitor
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate
Authors:Liu, S.J, Zhou, X.Y, Li, M.L, Sun, H.B, Wen, X.A.
Deposit date:2020-02-26
Release date:2021-03-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.255 Å)
Cite:N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.
Eur.J.Med.Chem., 199, 2020
6WVB
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BU of 6wvb by Molmil
Takifugu rubripes VKOR-like with warfarin
Descriptor: S-WARFARIN, Vitamin K epoxide reductase-like protein, termini restrained by green fluorescent protein
Authors:Liu, S, Sukumar, N, Li, W.
Deposit date:2020-05-05
Release date:2020-11-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.872 Å)
Cite:Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
Science, 371, 2021

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