1NTP
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3PGF
| Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | Descriptor: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | Authors: | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | Deposit date: | 2010-11-01 | Release date: | 2011-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat.Struct.Mol.Biol., 18, 2011
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1TGN
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1D9C
| BOVINE INTERFERON-GAMMA AT 2.0 ANGSTROMS | Descriptor: | INTERFERON-GAMMA | Authors: | Randal, M, Kossiakoff, A.A. | Deposit date: | 1999-10-27 | Release date: | 1999-11-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallogr.,Sect.D, 56, 2000
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1D9G
| BOVINE INTERFERON-GAMMA AT 2.9 ANGSTROMS | Descriptor: | INTERFERON-GAMMA | Authors: | Randal, M, Kossiakoff, A.A. | Deposit date: | 1999-10-27 | Release date: | 1999-11-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallogr.,Sect.D, 56, 2000
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3HHR
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3PJS
| Mechanism of Activation Gating in the Full-Length KcsA K+ Channel | Descriptor: | FAB heavy chain, FAB light chain, Voltage-gated potassium channel | Authors: | Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E. | Deposit date: | 2010-11-10 | Release date: | 2011-07-06 | Last modified: | 2011-08-03 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Mechanism of activation gating in the full-length KcsA K+ channel. Proc.Natl.Acad.Sci.USA, 108, 2011
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5W2B
| Crystal structure of C-terminal domain of Ebola (Reston) nucleoprotein in complex with Fab fragment | Descriptor: | Fab Heavy Chain, Fab Light Chain, Nucleoprotein | Authors: | Radwanska, M.J, Derewenda, U, Kossiakoff, A.A, Derewenda, Z.S. | Deposit date: | 2017-06-06 | Release date: | 2018-06-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab. Acta Crystallogr D Struct Biol, 74, 2018
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5EII
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4XTR
| Structure of Get3 bound to the transmembrane domain of Pep12 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | Deposit date: | 2015-01-23 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347, 2015
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4XVU
| Structure of Get3 bound to the transmembrane domain of Nyv1 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, Antibody heavy chain, ... | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | Deposit date: | 2015-01-28 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347, 2015
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4XWO
| Structure of Get3 bound to the transmembrane domain of Sec22 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | Deposit date: | 2015-01-29 | Release date: | 2015-03-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science, 347, 2015
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4XMN
| Structure of the yeast coat nucleoporin complex, space group P212121 | Descriptor: | Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (7.6 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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4XMM
| Structure of the yeast coat nucleoporin complex, space group C2 | Descriptor: | Antibody 57 heavy chain, Antibody 57 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (7.384 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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4XH2
| Crystal structure of human paxillin LD4 motif in complex with Fab fragment | Descriptor: | ACETATE ION, ACETYL GROUP, Fab Heavy Chain, ... | Authors: | Nocula-Lugowska, M, Lugowski, M, Salgia, R, Kossiakoff, A.A. | Deposit date: | 2015-01-04 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J.Mol.Biol., 427, 2015
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4XGZ
| Crystal structure of human paxillin LD2 motif in complex with Fab fragment | Descriptor: | 1,2-ETHANEDIOL, FAB HEAVY CHAIN, FAB LIGHT CHAIN, ... | Authors: | Nocula-Lugowska, M, Lugowski, M, Salgia, R, Kossiakoff, A.A. | Deposit date: | 2015-01-04 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J.Mol.Biol., 427, 2015
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5E08
| Specific Recognition of a Single-stranded RNA Sequence by an Engineered Synthetic Antibody Fragment | Descriptor: | Fab Heavy Chain, Fab Light Chain, RNA | Authors: | Huang, H, Qin, D, Li, N, Shao, Y, Staley, J.P, Kossiakoff, A.A, Koide, S, Piccirilli, J.A. | Deposit date: | 2015-09-28 | Release date: | 2016-09-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. J.Mol.Biol., 428, 2016
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1F6F
| CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | Deposit date: | 2000-06-21 | Release date: | 2000-07-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat.Struct.Biol., 7, 2000
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8PG0
| Human OATP1B3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2023-06-17 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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8PHW
| Human OATP1B1 | Descriptor: | CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ... | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2023-06-20 | Release date: | 2023-09-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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1FYH
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6RLX
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6U8C
| Crystal structure of an engineered ultra-high affinity Fab-Protein G complex | Descriptor: | Antibody heavy chain Fab, Antibody light chain Fab, Protein G | Authors: | Slezak, T, Filippova, E.V, Davydova, E.K, Kossiakoff, A.A. | Deposit date: | 2019-09-04 | Release date: | 2019-10-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Protein Sci., 29, 2020
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6UKJ
| Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | Descriptor: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | Authors: | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | Deposit date: | 2019-10-05 | Release date: | 2019-12-04 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature, 576, 2019
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6SNI
| Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | Descriptor: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | Deposit date: | 2019-08-24 | Release date: | 2020-03-11 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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