3BSA
| Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | Descriptor: | 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase | Authors: | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | Deposit date: | 2007-12-23 | Release date: | 2008-12-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
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4FD7
| Crystal structure of insect putative arylalkylamine N-Acetyltransferase 7 from the yellow fever mosquito Aedes aegypt | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, SULFATE ION, ... | Authors: | Han, Q, Robinson, R, Li, J. | Deposit date: | 2012-05-26 | Release date: | 2012-06-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti. Proc.Natl.Acad.Sci.USA, 109, 2012
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2R2N
| The crystal structure of human kynurenine aminotransferase II in complex with kynurenine | Descriptor: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | Authors: | Han, Q, Robinson, H, Li, J. | Deposit date: | 2007-08-27 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of human kynurenine aminotransferase II. J.Biol.Chem., 283, 2008
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4FD6
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2R5C
| Aedes Kynurenine Aminotransferase in Complex with Cysteine | Descriptor: | Kynurenine aminotransferase, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-CYSTEINE | Authors: | Han, Q, Gao, Y.G, Robinson, H, Li, J. | Deposit date: | 2007-09-03 | Release date: | 2008-03-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase. Biochemistry, 47, 2008
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7RXY
| Hen egg-white lysozyme with ionic liquid ethylammonium nitrate 5 mol% | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | Deposit date: | 2021-08-24 | Release date: | 2023-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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7RZ0
| Hen egg-white lysozyme with ionic liquid ethanolammonium formate 6.7 mol% | Descriptor: | ETHANOLAMINE, FORMIC ACID, Lysozyme C | Authors: | Han, Q, Darmanin, C, Drummond, C, Greaves, T. | Deposit date: | 2021-08-27 | Release date: | 2023-03-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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7RYK
| Hen egg-white lysozyme with ionic liquid ethanolammonium nitrate 1 mol% | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | Deposit date: | 2021-08-25 | Release date: | 2023-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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7RYD
| Hen egg-white lysozyme with ionic liquid butylammonium nitrate 1 mol% | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | Deposit date: | 2021-08-25 | Release date: | 2023-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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7RZ2
| Hen egg-white lysozyme with ionic liquid ethanolammonium formate 4 mol% | Descriptor: | ETHANOLAMINE, FORMIC ACID, Lysozyme C | Authors: | Han, Q, Darmanin, C, Drummond, C, Greaves, T. | Deposit date: | 2021-08-27 | Release date: | 2023-03-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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7RZ1
| Hen egg-white lysozyme with ionic liquid ethanolammonium formate 14.4 mol% | Descriptor: | ETHANOLAMINE, FORMIC ACID, Lysozyme C | Authors: | Han, Q, Darmanin, C, Drummond, C, Greaves, T. | Deposit date: | 2021-08-27 | Release date: | 2023-03-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.046 Å) | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids. J Colloid Interface Sci, 650, 2023
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2R5E
| Aedes kynurenine aminotransferase in complex with glutamine | Descriptor: | Kynurenine aminotransferase, N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE | Authors: | Han, Q, Gao, Y.G, Robinson, H, Li, J. | Deposit date: | 2007-09-03 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase. Biochemistry, 47, 2008
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1YRJ
| Crystal Structure of Apramycin bound to a Ribosomal RNA A site oligonucleotide | Descriptor: | APRAMYCIN, Bacterial 16 S Ribosomal RNA A Site Oligonucleotide, MAGNESIUM ION, ... | Authors: | Han, Q, Zhao, Q, Fish, S, Simonsen, K.B, Vourloumis, D, Froelich, J.M, Wall, D, Hermann, T. | Deposit date: | 2005-02-03 | Release date: | 2005-06-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex. Angew.Chem.Int.Ed.Engl., 44, 2005
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4HU8
| Crystal Structure of a Bacterial Ig-like Domain Containing GH10 Xylanase from Termite Gut | Descriptor: | GH10 Xylanase, GLYCEROL, SULFATE ION | Authors: | Han, Q, Liu, N, Robinson, H, Cao, L, Qian, C, Wang, Q, Xie, L, Ding, H, Wang, Q, Huang, Y, Li, J, Zhou, Z. | Deposit date: | 2012-11-02 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical characterization and crystal structure of a GH10 xylanase from termite gut bacteria reveal a novel structural feature and significance of its bacterial Ig-like domain. Biotechnol.Bioeng., 110, 2013
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3E2Y
| Crystal structure of mouse kynurenine aminotransferase III in complex with glutamine | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMINE, GLYCEROL, ... | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-06 | Release date: | 2008-12-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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3E2Z
| Crystal structure of mouse kynurenine aminotransferase III in complex with kynurenine | Descriptor: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-06 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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3E2F
| Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form | Descriptor: | GLYCEROL, Kynurenine-oxoglutarate transaminase 3 | Authors: | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | Deposit date: | 2008-08-05 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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2QLR
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3H2L
| Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor | Descriptor: | N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase | Authors: | Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. | Deposit date: | 2009-04-14 | Release date: | 2009-12-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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6CJ5
| Crystal Structure of Mnk2-D228G in Complex With Inhibitor | Descriptor: | 3-(pyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-26 | Release date: | 2018-05-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CK6
| Crystal Structure of Mnk2-D228G in complex with Inhibitor | Descriptor: | 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-27 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CKI
| Co-crystal structure of MNK2 in Complex With Inhibitor | Descriptor: | 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-28 | Release date: | 2018-05-09 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CJH
| Co-crystal structure of MNK2 in complex with an inhibitor | Descriptor: | 3-phenyl-5-(pyridin-4-yl)-1H-indazole, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-26 | Release date: | 2018-05-09 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CJE
| Crystal Structure of Mnk2-D228G in complex with Inhibitor | Descriptor: | 4-[(9H-purin-6-yl)amino]benzamide, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-26 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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6CJY
| Crystal Structure of Mnk2-D228G in complex with Inhibitor | Descriptor: | 5-[(7H-purin-6-yl)amino]-1H-isoindol-1-one, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Han, Q. | Deposit date: | 2018-02-27 | Release date: | 2018-05-09 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J. Med. Chem., 61, 2018
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