4R8J
 
 | | d(TCGGCGCCGA) with lambda-[Ru(TAP)2(dppz)]2+ soaked in D2O | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*(THM)P*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), ... | | Authors: | Hall, J.P, Gurung, S.P, Winter, G.W, Cardin, C.J. | | Deposit date: | 2014-09-02 | | Release date: | 2015-10-28 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy.
Nat Chem, 7, 2015
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4RE7
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(TCIGCGCCGA) | | Descriptor: | 5'-D(*TP*CP*IP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2014-09-22 | | Release date: | 2015-09-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.181 Å) | | Cite: | The effects of DNA modification on the binding of polypyridyl ruthenium complexes
To be Published
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6NAO
 | | Discovery of a high affinity inhibitor of cGAS | | Descriptor: | (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION | | Authors: | Hall, J. | | Deposit date: | 2018-12-06 | | Release date: | 2018-12-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.23 Å) | | Cite: | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
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4X18
 | | [Ru(TAP)2(dppz-11-Me)]2+ bound to d(TCGGCGCCGA) | | Descriptor: | (11-methyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium, BARIUM ION, CHLORIDE ION, ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2014-11-24 | | Release date: | 2015-05-13 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru-dppz Complexes to DNA
Organometallics, 2015
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4X1A
 | | Lambda-[Ru(TAP)2(dppz-10,12-Me)]2+ bound to d(TCGGCGCCGA) | | Descriptor: | (10,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium, BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3') | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2014-11-24 | | Release date: | 2015-05-13 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (0.89 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru-dppz Complexes to DNA
Organometallics, 2015
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5LFX
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5LFS
 | | Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*(CBR)P*GP*GP*C)-3'), ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-07-04 | | Release date: | 2017-02-15 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.
Chemistry, 23, 2017
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5LFW
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5ET2
 | | Lambda-Ru(TAP)2(dppz)]2+ bound to d(TTGGCGCCAA) | | Descriptor: | BARIUM ION, DNA (5'-D(*(THM)P*TP*GP*GP*CP*GP*CP*CP*AP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2015-11-17 | | Release date: | 2016-11-23 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru(II) Complex due to Structural Change in the Minor Groove.
Chemistry, 23, 2017
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4E8S
 | | Lambda-[Ru(TAP)2(dppz{Me2}2)]2+ bound to TCGGCGCCGA at high resolution | | Descriptor: | (11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-20 | | Release date: | 2013-03-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru dppz Complexes to DNA
Organometallics, 2015
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4E7Y
 | | Lambda-[Ru(phen)2(dppz)]2+ Bound to CCGGATCCGG | | Descriptor: | 5'-D(*CP*CP*GP*GP*AP*TP*CP*CP*GP*G)-3', BARIUM ION, Lambda-Ru(phen)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-19 | | Release date: | 2012-07-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure of lambda-[Ru(phen)2(dppz)]2+ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes.
Nat Chem, 4, 2012
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5IU5
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(TCGGCICCGA)2 | | Descriptor: | BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*IP*CP*CP*GP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-03-17 | | Release date: | 2017-06-21 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Unexpected enhancement of sensitised photo-oxidation by a Ru(II) complex on replacement of guanine with inosine in DNA
To Be Published
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5JEV
 | | del-[Ru(phen)2(dppz]2+ bound to d(TCGGCGCCGA) with Cobalt hexammine | | Descriptor: | COBALT HEXAMMINE(III), DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), Delta-Ru(phen)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-04-19 | | Release date: | 2016-09-14 | | Last modified: | 2016-11-09 | | Method: | X-RAY DIFFRACTION (0.99 Å) | | Cite: | Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes.
Nucleic Acids Res., 44, 2016
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5JEU
 | | del-[Ru(phen)2(dppz)]2+ bound to d(TCGGCGCCGA) with Ba2+ | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-04-19 | | Release date: | 2016-09-14 | | Last modified: | 2016-11-09 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes.
Nucleic Acids Res., 44, 2016
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3GLW
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4III
 | | Lambda-[Ru(TAP)2(11-Cl-dppz)] with a DNA decamer at atomic resolution | | Descriptor: | 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, Ru(TAP)2(Cl-dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-12-20 | | Release date: | 2013-07-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Preferred orientation in an angled intercalation site of a chloro-substituted Lambda-[Ru(TAP)2(dppz)]2+ complex bound to d(TCGGCGCCGA)2.
Philos Trans A Math Phys Eng Sci, 371, 2013
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4E8X
 | | Lambda-[Ru(TAP)2(dppz-(Me)2)]2+ bound to d(CCGGCGCCGG)2 | | Descriptor: | (11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), 5'-D(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3', BARIUM ION | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-20 | | Release date: | 2013-03-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | The effects of disubstitution on the binding of ruthenium complexes to DNA
Thesis, University of Reading, 2014
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4E95
 | | Lambda-[Ru(TAP)2(dppz-(Me)2)]2+ bound to CCGGATCCGG | | Descriptor: | (11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), 5'-D(*CP*CP*GP*GP*AP*TP*CP*CP*GP*G)-3', BARIUM ION | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-20 | | Release date: | 2013-03-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The effects of disubstitution on the binding of ruthenium complexes to DNA
Thesis, University of Reading, 2014
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4IZQ
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4LTJ
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4LTI
 | | Dehydration/Rehydration of a Nucleic Acid system containing a Polypyridyl Ruthenium Complex at 74% relative humidity (4/7) | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA, ... | | Authors: | Hall, J.P, Sanchez-Weatherby, J, Cardin, C.J. | | Deposit date: | 2013-07-23 | | Release date: | 2014-09-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Controlled Dehydration of a Ruthenium Complex-DNA Crystal Induces Reversible DNA Kinking.
J.Am.Chem.Soc., 136, 2014
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4LTL
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4LTF
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4LTK
 | | Dehydration/Rehydration of a Nucleic Acid system containing a Polypyridyl Ruthenium Complex at 74% relative humidity (6/7) | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA, ... | | Authors: | Hall, J.P, Sanchez-Weatherby, J, Cardin, C.J. | | Deposit date: | 2013-07-23 | | Release date: | 2014-09-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Controlled Dehydration of a Ruthenium Complex-DNA Crystal Induces Reversible DNA Kinking.
J.Am.Chem.Soc., 136, 2014
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4LTG
 | | Dehydration/Rehydration of a Nucleic Acid system containing a Polypyridyl Ruthenium Complex at 74% relative humidity (2/7) | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA, ... | | Authors: | Hall, J.P, Sanchez-Weatherby, J, Cardin, C.J. | | Deposit date: | 2013-07-23 | | Release date: | 2014-09-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Controlled Dehydration of a Ruthenium Complex-DNA Crystal Induces Reversible DNA Kinking.
J.Am.Chem.Soc., 136, 2014
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