5WOC
 
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6MCT
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3AL1
 | | DESIGNED PEPTIDE ALPHA-1, RACEMIC P1BAR FORM | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOLAMINE, PROTEIN (D, ... | | Authors: | Patterson, W.R, Anderson, D.H, Degrado, W.F, Cascio, D, Eisenberg, D. | | Deposit date: | 1998-10-26 | | Release date: | 1998-11-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (0.75 Å) | | Cite: | Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1.
Protein Sci., 8, 1999
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1U7M
 | | Solution structure of a diiron protein model: Due Ferri(II) turn mutant | | Descriptor: | Four-helix bundle model, ZINC ION | | Authors: | Maglio, O, Nastri, F, Calhoun, J.R, Lahr, S, Pavone, V, DeGrado, W.F, Lombardi, A. | | Deposit date: | 2004-08-04 | | Release date: | 2005-03-01 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
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1U7J
 | | Solution structure of a diiron protein model | | Descriptor: | Four-helix bundle model, ZINC ION | | Authors: | Maglio, O, Nastri, F, Calhoun, J.R, Lahr, S, Pavone, V, DeGrado, W.F, Lombardi, A. | | Deposit date: | 2004-08-04 | | Release date: | 2005-03-01 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
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1G6U
 | | CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER | | Descriptor: | DOMAIN SWAPPED DIMER, SULFATE ION, trifluoroacetic acid | | Authors: | Ogihara, N.L, Ghirlanda, G, Bryson, J.W, Gingery, M, DeGrado, W.F, Eisenberg, D. | | Deposit date: | 2000-11-07 | | Release date: | 2001-02-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Design of three-dimensional domain-swapped dimers and fibrous oligomers.
Proc.Natl.Acad.Sci.USA, 98, 2001
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5JOO
 | | XFEL structure of influenza A M2 wild type TM domain at low pH in the lipidic cubic phase at room temperature | | Descriptor: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | | Authors: | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | | Deposit date: | 2016-05-02 | | Release date: | 2017-08-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.413 Å) | | Cite: | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2HZ8
 | | QM/MM structure refined from NMR-structure of a single chain diiron protein | | Descriptor: | De novo designed diiron protein, ZINC ION | | Authors: | Calhoun, J.R, Liu, W, Spiegel, K, Dal Peraro, M, Klein, M.L, Wand, A.J, DeGrado, W.F. | | Deposit date: | 2006-08-08 | | Release date: | 2007-07-17 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure, 16, 2008
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1NVO
 | | Solution structure of a four-helix bundle model, apo-DF1 | | Descriptor: | Homodimeric Alpha2 Four-Helix Bundle | | Authors: | Maglio, O, Nastri, F, Pavone, V, Lombardi, A, DeGrado, W.F. | | Deposit date: | 2003-02-04 | | Release date: | 2003-03-25 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Preorganization of molecular binding sites in designed diiron proteins
Proc.Natl.Acad.Sci.USA, 100, 2003
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6OUG
 | | Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct | | Descriptor: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2 | | Authors: | Thomaston, J.L, Liu, L, DeGrado, W.F. | | Deposit date: | 2019-05-04 | | Release date: | 2020-01-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
Biochemistry, 59, 2020
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3LBW
 | | High resolution crystal structure of transmembrane domain of M2 | | Descriptor: | 4-bromobenzoic acid, DI(HYDROXYETHYL)ETHER, M2 protein, ... | | Authors: | Acharya, R, Polishchuk, A.L, DeGrado, W.F. | | Deposit date: | 2010-01-08 | | Release date: | 2010-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Proc.Natl.Acad.Sci.USA, 107, 2010
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7UDW
 | | Designed pentameric proton channel QQLL | | Descriptor: | De novo designed pentameric proton channel QQLL | | Authors: | Kratochvil, H.T, Thomaston, J.L, Mravic, M, Nicoludis, J, Liu, L, DeGrado, W.F. | | Deposit date: | 2022-03-20 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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7UDX
 | | Designed pentameric proton channel QLQL | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed pentameric proton channel QLQL | | Authors: | Kratochvil, H.T, Thomaston, J.L, Liu, L, DeGrado, W.F. | | Deposit date: | 2022-03-20 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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2A3D
 | | SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D) | | Descriptor: | PROTEIN (DE NOVO THREE-HELIX BUNDLE) | | Authors: | Walsh, S.T.R, Cheng, H, Bryson, J.W, Roder, H, Degrado, W.F. | | Deposit date: | 1999-04-01 | | Release date: | 1999-05-05 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure and dynamics of a de novo designed three-helix bundle protein.
Proc.Natl.Acad.Sci.USA, 96, 1999
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3S0R
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3V86
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7UDZ
 | | Designed pentameric proton channel LQLL | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed pentameric proton channel LQLL | | Authors: | Kratochvil, H.T, Thomaston, J.L, Mravic, M, Nicoludis, J.M, Liu, L, DeGrado, W.F. | | Deposit date: | 2022-03-20 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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7UDY
 | | Designed pentameric channel QLLL | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Designed channel QLLL | | Authors: | Kratochvil, H.T, Thomaston, J.L, Liu, L, DeGrado, W.F. | | Deposit date: | 2022-03-20 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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7UDV
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3UUG
 | | Crystal structure of the periplasmic sugar binding protein ChvE | | Descriptor: | Multiple sugar-binding periplasmic receptor ChvE, beta-D-glucopyranuronic acid | | Authors: | Hu, X, Zhao, J, Binns, A, Degrado, W. | | Deposit date: | 2011-11-28 | | Release date: | 2012-11-28 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3URM
 | | Crystal structure of the periplasmic sugar binding protein ChvE | | Descriptor: | Multiple sugar-binding periplasmic receptor ChvE, beta-D-galactopyranose | | Authors: | Hu, X, Zhao, J, Binns, A, Degrado, W. | | Deposit date: | 2011-11-22 | | Release date: | 2012-11-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5ET3
 | | Crystal Structure of De novo Designed Fullerene organizing peptide | | Descriptor: | (C_{60}-I_{h})[5,6]fullerene, Fullerene Organizing Protein (C60Sol-COP-3) | | Authors: | Kim, K.-H, Kim, Y.H, Acharya, R, Kim, N.H, Paul, J, Grigoryan, G, DeGrado, W.F. | | Deposit date: | 2015-11-17 | | Release date: | 2016-05-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.671 Å) | | Cite: | Protein-directed self-assembly of a fullerene crystal.
Nat Commun, 7, 2016
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2KZ2
 | | Calmodulin, C-terminal domain, F92E mutant | | Descriptor: | CALCIUM ION, Calmodulin | | Authors: | Korendovych, I, Kulp, D, Wu, Y, Cheng, H, Roder, H, DeGrado, W. | | Deposit date: | 2010-06-10 | | Release date: | 2011-04-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Design of a switchable eliminase.
Proc.Natl.Acad.Sci.USA, 108, 2011
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6YB1
 | | Crystal structure of an antiparallel octameric transmembrane coiled coil K2-CCTM-VbIc | | Descriptor: | GLYCINE, K2-CCTM-VbIc, NONAETHYLENE GLYCOL | | Authors: | Kratochvil, H.T, Liu, L, Scott, A.J, Woolfson, D.N, DeGrado, W.F. | | Deposit date: | 2020-03-15 | | Release date: | 2021-04-07 | | Last modified: | 2021-07-14 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Constructing ion channels from water-soluble alpha-helical barrels.
Nat.Chem., 13, 2021
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6US9
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