8ETG
 
 | | Fkbp39 associated 60S nascent ribosome State 3 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ETJ
 | | Fkbp39 associated 60S nascent ribosome State 2 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ESR
 | | Ytm1 associated nascent 60S ribosome (-fkbp39) State 2 | | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8EV3
 | | Ytm1 associated 60S nascent ribosome (-Fkbp39) State 1B | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-19 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ETC
 | | Fkbp39 associated nascent 60S ribosome State 4 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-16 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ESQ
 | | Ytm1 associated nascent 60S ribosome State 2 | | Descriptor: | 25S rRNA (cytosine-C(5))-methyltransferase nop2, 60S ribosomal protein L13, 60S ribosomal protein L14, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8EUG
 | | Ytm1 associated nascent 60S ribosome State 3 | | Descriptor: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8ETI
 | | Fkbp39 associated 60S nascent ribosome State 1 | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-17 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8EUY
 | | Ytm1 associated nascent 60S ribosome (-fkbp39) State 1A | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-19 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8EUP
 | | Ytm1 associated 60S nascent ribosome State 1A | | Descriptor: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-19 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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8EUI
 | | Ytm1 associated nascent 60S ribosome (-fkbp39) State 3 | | Descriptor: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | | Authors: | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Mol.Cell, 82, 2022
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1BT7
 | | THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES | | Descriptor: | NS3 SERINE PROTEASE, ZINC ION | | Authors: | Barbato, G, Cicero, D.O, Nardi, M.C, Steinkuhler, C, Cortese, R, De Francesco, R, Bazzo, R. | | Deposit date: | 1998-09-01 | | Release date: | 1999-06-22 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
J.Mol.Biol., 289, 1999
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7CBT
 | | The crystal structure of SARS-CoV-2 main protease in complex with GC376 | | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | | Authors: | Shi, Y, Peng, G. | | Deposit date: | 2020-06-13 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.346 Å) | | Cite: | The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10, 2021
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7CHV
 | | Metallo-Beta-Lactamase VIM-2 in complex with 1-benzyl-1H-imidazole-2-carboxylic acid | | Descriptor: | 1-(phenylmethyl)imidazole-2-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ... | | Authors: | Yan, Y.-H, Li, G.-B. | | Deposit date: | 2020-07-06 | | Release date: | 2021-07-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.174 Å) | | Cite: | AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-beta-lactamases and indoleamine/tryptophan 2,3-dioxygenases.
Acta Pharm Sin B, 11, 2021
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1VPN
 | | UNASSEMBLED POLYOMAVIRUS VP1 PENTAMER | | Descriptor: | POLYOMAVIRUS VP1 PENTAMER | | Authors: | Stehle, T, Harrison, S.C. | | Deposit date: | 1997-03-07 | | Release date: | 1997-05-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding.
Embo J., 16, 1997
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1VPS
 | | POLYOMAVIRUS VP1 PENTAMER COMPLEXED WITH A DISIALYLATED HEXASACCHARIDE | | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, POLYOMAVIRUS VP1 PENTAMER | | Authors: | Stehle, T, Harrison, S.C. | | Deposit date: | 1997-03-07 | | Release date: | 1997-05-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding.
Embo J., 16, 1997
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7T9V
 | | Crystal structure of hSTING with the agonist, SHR171032 | | Descriptor: | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | | Authors: | Chowdhury, R, Miller, M. | | Deposit date: | 2021-12-20 | | Release date: | 2022-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
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7T9U
 | | Crystal structure of hSTING with an agonist (SHR169224) | | Descriptor: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | | Authors: | Chowdhury, R, Miller, M. | | Deposit date: | 2021-12-20 | | Release date: | 2022-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
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7CNA
 | | Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide | | Descriptor: | ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY, ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR, BENZAMIDINE, ... | | Authors: | Qian, C.M. | | Deposit date: | 2020-07-30 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation.
Nat Commun, 12, 2021
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5YS1
 | | Crystal structure of Multicopper Oxidase CueO G304K mutant | | Descriptor: | Blue copper oxidase CueO, COPPER (II) ION | | Authors: | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | | Deposit date: | 2017-11-12 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
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5YS5
 | | Crystal structure of Multicopper Oxidase CueO G304K mutant with seven copper ions | | Descriptor: | Blue copper oxidase CueO, COPPER (II) ION | | Authors: | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | | Deposit date: | 2017-11-13 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
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3F1S
 | | Crystal structure of Protein Z complexed with protein Z-dependent inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Zhou, A. | | Deposit date: | 2008-10-28 | | Release date: | 2009-06-30 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.
Blood, 2009
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6XFP
 | | Crystal Structure of BRAF kinase domain bound to Belvarafenib | | Descriptor: | 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide, CHLORIDE ION, Serine/threonine-protein kinase B-raf | | Authors: | Yin, J, Sudhamsu, J. | | Deposit date: | 2020-06-16 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Nature, 594, 2021
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2RIV
 | | Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin | | Descriptor: | GLYCEROL, SULFATE ION, Thyroxine-binding globulin | | Authors: | Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W. | | Deposit date: | 2007-10-12 | | Release date: | 2008-10-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
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2RIW
 | | The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine | | Descriptor: | 3,5,3',5'-TETRAIODO-L-THYRONINE, Thyroxine-binding globulin | | Authors: | Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W. | | Deposit date: | 2007-10-12 | | Release date: | 2008-10-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
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