3IQL
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![BU of 3iql by Molmil](/molmil-images/mine/3iql) | Crystal structure of the rat endophilin-A1 SH3 domain | Descriptor: | CHLORIDE ION, Endophilin-A1 | Authors: | Trempe, J.F, Kozlov, G, Camacho, E.M, Gehring, K. | Deposit date: | 2009-08-20 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol.Cell, 36, 2009
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3M3J
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![BU of 3m3j by Molmil](/molmil-images/mine/3m3j) | A new crystal form of Lys48-linked diubiquitin | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin | Authors: | Trempe, J.F, Brown, N.R, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2010-03-09 | Release date: | 2010-03-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A new crystal form of Lys48-linked diubiquitin. Acta Crystallogr.,Sect.F, 66, 2010
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6DJX
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![BU of 6djx by Molmil](/molmil-images/mine/6djx) | Crystal Structure of pParkin-pUb-UbcH7 complex | Descriptor: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | Deposit date: | 2018-05-27 | Release date: | 2018-07-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.801 Å) | Cite: | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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8UDC
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![BU of 8udc by Molmil](/molmil-images/mine/8udc) | Crystal structure of TcPINK1 in complex with CYC116 | Descriptor: | (4P)-4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | Authors: | Veyron, S, Rasool, S, Trempe, J.F. | Deposit date: | 2023-09-28 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Characterization of a small-molecule inhibitor of PINK1, a precursor tool compound for the study of Parkinson's disease To Be Published
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8UCT
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![BU of 8uct by Molmil](/molmil-images/mine/8uct) | Crystal structure of TcPINK1 in complex with PRT | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide, SULFATE ION, ... | Authors: | Veyron, S, Rasool, S, Trempe, J.F. | Deposit date: | 2023-09-27 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Characterization of a new family of PINK1 inhibitors To Be Published
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6DJW
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![BU of 6djw by Molmil](/molmil-images/mine/6djw) | Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex | Descriptor: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | Deposit date: | 2018-05-26 | Release date: | 2018-07-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.801 Å) | Cite: | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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6UCC
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![BU of 6ucc by Molmil](/molmil-images/mine/6ucc) | Structure of human PACRG-MEIG1 complex (limited proteolysis) | Descriptor: | DI(HYDROXYETHYL)ETHER, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | Authors: | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | Deposit date: | 2019-09-16 | Release date: | 2019-10-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of human PACRG in complex with MEIG1 Biorxiv, 2019
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4ZYN
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![BU of 4zyn by Molmil](/molmil-images/mine/4zyn) | Crystal Structure of Parkin E3 ubiquitin ligase (linker deletion; delta 86-130) | Descriptor: | E3 ubiquitin-protein ligase parkin, SULFATE ION, ZINC ION | Authors: | Lilov, A, Sauve, V, Trempe, J.F, Rodionov, D, Wang, J, Gehring, K. | Deposit date: | 2015-05-21 | Release date: | 2015-08-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | A Ubl/ubiquitin switch in the activation of Parkin. Embo J., 34, 2015
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7MP9
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![BU of 7mp9 by Molmil](/molmil-images/mine/7mp9) | Crystal structure of the cytosolic domain of Tribolium castaneum PINK1 phosphorylated at Ser205 in complex with ADP analog | Descriptor: | AMP PHOSPHORAMIDATE, MAGNESIUM ION, SULFATE ION, ... | Authors: | Rasool, S, Veyron, S, Trempe, J.F. | Deposit date: | 2021-05-04 | Release date: | 2021-12-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex. Mol.Cell, 82, 2022
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7MP8
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![BU of 7mp8 by Molmil](/molmil-images/mine/7mp8) | |
1NEE
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![BU of 1nee by Molmil](/molmil-images/mine/1nee) | Structure of archaeal translation factor aIF2beta from Methanobacterium thermoautrophicum | Descriptor: | Probable translation initiation factor 2 beta subunit, ZINC ION | Authors: | Gutierrez, P, Trempe, J.F, Siddiqui, N, Arrowsmith, C, Gehring, K. | Deposit date: | 2002-12-11 | Release date: | 2004-03-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the archaeal translation initiation factor aIF2beta from Methanobacterium thermoautotrophicum: Implications for translation initiation. Protein Sci., 13, 2004
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1NMR
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![BU of 1nmr by Molmil](/molmil-images/mine/1nmr) | Solution Structure of C-terminal Domain from Trypanosoma cruzi Poly(A)-Binding Protein | Descriptor: | poly(A)-binding protein | Authors: | Siddiqui, N, Kozlov, G, D'Orso, I, Trempe, J.F, Frasch, A.C.C, Gehring, K. | Deposit date: | 2003-01-10 | Release date: | 2003-09-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the C-terminal Domain from poly(A)-binding protein in Trypanosoma cruzi: A vegetal PABC domain Protein Sci., 12, 2003
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6NEP
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![BU of 6nep by Molmil](/molmil-images/mine/6nep) | Structure of human PACRG-MEIG1 complex | Descriptor: | CHLORIDE ION, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | Authors: | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | Deposit date: | 2018-12-18 | Release date: | 2019-10-23 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (2.097625 Å) | Cite: | Crystal structure of human PACRG in complex with MEIG1 Biorxiv, 2019
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6NDU
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![BU of 6ndu by Molmil](/molmil-images/mine/6ndu) | Structure of human PACRG-MEIG1 complex | Descriptor: | CHLORIDE ION, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | Authors: | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | Deposit date: | 2018-12-14 | Release date: | 2019-10-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human PACRG in complex with MEIG1 Biorxiv, 2019
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5KES
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![BU of 5kes by Molmil](/molmil-images/mine/5kes) | Solution structure of the yeast Ddi1 HDD domain | Descriptor: | DNA damage-inducible protein 1 | Authors: | Trempe, J.-F, Ratcliffe, C, Veverka, V, Saskova, K, Gehring, K. | Deposit date: | 2016-06-10 | Release date: | 2016-10-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family. Sci Rep, 6, 2016
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2KNB
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![BU of 2knb by Molmil](/molmil-images/mine/2knb) | Solution NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domain | Descriptor: | E3 ubiquitin-protein ligase parkin, Endophilin-A1 | Authors: | Trempe, J, Guennadi, K, Edna, C.M, Kalle, G. | Deposit date: | 2009-08-20 | Release date: | 2009-12-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol.Cell, 36, 2009
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4Z2Z
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![BU of 4z2z by Molmil](/molmil-images/mine/4z2z) | |
4K7D
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![BU of 4k7d by Molmil](/molmil-images/mine/4k7d) | Crystal Structure of Parkin C-terminal RING domains | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin, MALONATE ION, ... | Authors: | Sauve, V, Trempe, J.-F, Menade, M, Gehring, K. | Deposit date: | 2013-04-17 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science, 340, 2013
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4K95
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![BU of 4k95 by Molmil](/molmil-images/mine/4k95) | Crystal Structure of Parkin | Descriptor: | E3 ubiquitin-protein ligase parkin, ZINC ION | Authors: | Seirafi, M, Menade, M, Sauve, V, Kozlov, G, Trempe, J.-F, Nagar, B, Gehring, K. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (6.499 Å) | Cite: | Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science, 340, 2013
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1FC8
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![BU of 1fc8 by Molmil](/molmil-images/mine/1fc8) | |
2N7E
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![BU of 2n7e by Molmil](/molmil-images/mine/2n7e) | |
2X5N
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![BU of 2x5n by Molmil](/molmil-images/mine/2x5n) | Crystal Structure of the SpRpn10 VWA domain | Descriptor: | 26S PROTEASOME REGULATORY SUBUNIT RPN10, SULFATE ION | Authors: | Riedinger, C, Boehringer, J, Trempe, J.-F, Lowe, E.D, Brown, N.R, Gehring, K, Noble, M.E.M, Gordon, C, Endicott, J.A. | Deposit date: | 2010-02-10 | Release date: | 2010-08-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12. J.Biol.Chem., 285, 2010
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3LVL
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![BU of 3lvl by Molmil](/molmil-images/mine/3lvl) | Crystal Structure of E.coli IscS-IscU complex | Descriptor: | Cysteine desulfurase, NifU-like protein, PYRIDOXAL-5'-PHOSPHATE | Authors: | Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2010-02-22 | Release date: | 2010-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. Plos Biol., 8, 2010
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5K57
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![BU of 5k57 by Molmil](/molmil-images/mine/5k57) | HDD domain from human Ddi2 | Descriptor: | Protein DDI1 homolog 2 | Authors: | Veverka, V. | Deposit date: | 2016-05-23 | Release date: | 2016-08-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. Sci Rep, 6, 2016
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6NBX
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![BU of 6nbx by Molmil](/molmil-images/mine/6nbx) | T.elongatus NDH (data-set 2) | Descriptor: | IRON/SULFUR CLUSTER, NAD(P)H-quinone oxidoreductase chain 4 1, NAD(P)H-quinone oxidoreductase subunit 1, ... | Authors: | Laughlin, T.G, Bayne, A, Trempe, J.-F, Savage, D.F, Davies, K.M. | Deposit date: | 2018-12-10 | Release date: | 2019-02-27 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the complex I-like molecule NDH of oxygenic photosynthesis. Nature, 566, 2019
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