5GAI
 
 | | Probabilistic Structural Models of Mature P22 Bacteriophage Portal, Hub, and Tailspike proteins | | Descriptor: | Peptidoglycan hydrolase gp4, Portal protein, Tail fiber protein | | Authors: | Pintilie, G, Chen, D.H, Haase-Pettingell, C.A, King, J.A, Chiu, W. | | Deposit date: | 2015-12-01 | | Release date: | 2016-02-17 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (10.5 Å) | | Cite: | Resolution and Probabilistic Models of Components in CryoEM Maps of Mature P22 Bacteriophage.
Biophys.J., 110, 2016
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6OJN
 | | Comparative Model of SGIV Major Coat Protein (MCP) Trimer Based on Cryo-EM Map | | Descriptor: | Major capsid protein | | Authors: | Pintilie, G, Chen, D.-H, Tran, B.N, Jakana, J, Wu, J, Hew, C.L, Chiu, W. | | Deposit date: | 2019-04-11 | | Release date: | 2019-06-12 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.6 Å) | | Cite: | Segmentation and Comparative Modeling in an 8.6- angstrom Cryo-EM Map of the Singapore Grouper Iridovirus.
Structure, 27, 2019
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8FR7
 | | A hinge glycan regulates spike bending and impacts coronavirus infectivity | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Pintilie, G, Wilson, E, Chmielewski, D, Schmid, M.F, Jin, J, Chen, M, Singharoy, A, Chiu, W. | | Deposit date: | 2023-01-06 | | Release date: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | A hinge glycan regulates spike bending and impacts coronavirus infectivity
To Be Published
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6M0S
 | | 3.6A Yeast Vo state3 prime | | Descriptor: | Uncharacterized protein YPR170W-B, V-type proton ATPase subunit a, vacuolar isoform, ... | | Authors: | Roh, S.H, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, SIngharoy, A, Chiu, W. | | Deposit date: | 2020-02-22 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex.
Sci Adv, 6, 2020
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7UPH
 | | Structure of a ribosome with tethered subunits | | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | Authors: | Kim, D.S, Watkins, A, Bidstrup, E, Lee, J, Topkar, V.V, Kofman, C, Schwarz, K.J, Liu, Y, Pintilie, G, Roney, E, Das, R, Jewett, M.C. | | Deposit date: | 2022-04-15 | | Release date: | 2022-08-17 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Three-dimensional structure-guided evolution of a ribosome with tethered subunits.
Nat.Chem.Biol., 18, 2022
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6D00
 | | Calcarisporiella thermophila Hsp104 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Calcarisporiella thermophila Hsp104 | | Authors: | Zhang, K, Pintilie, G. | | Deposit date: | 2018-04-09 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure, 27, 2019
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6C6L
 | | Yeast Vacuolar ATPase Vo in lipid nanodisc | | Descriptor: | V-type proton ATPase subunit a, vacuolar isoform, V-type proton ATPase subunit c, ... | | Authors: | Roh, S, Stam, N.J, Hryc, C, Couoh-Cardel, S, Pintilie, G, Chiu, W, Wilkens, S. | | Deposit date: | 2018-01-19 | | Release date: | 2018-03-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The 3.5- angstrom CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase VoProton Channel.
Mol. Cell, 69, 2018
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7KIP
 | | A 3.4 Angstrom cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Zhang, K, Li, S, Pintilie, G, Chmielewski, D, Schmid, M, Simmons, G, Jin, J, Chiu, W. | | Deposit date: | 2020-10-24 | | Release date: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | A 3.4- angstrom cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
Biorxiv, 2020
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7JM3
 | | Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer | | Descriptor: | Matrix protein 1 | | Authors: | Su, Z, Pintilie, G, Selzer, L, Chiu, W, Kirkegaard, K. | | Deposit date: | 2020-07-30 | | Release date: | 2020-08-12 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer.
Plos Biol., 18, 2020
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6NRA
 | | hTRiC-hPFD Class1 (No PFD) | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6NRC
 | | hTRiC-hPFD Class3 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.3 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6NR9
 | | hTRiC-hPFD Class5 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.5 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6NRD
 | | hTRiC-hPFD Class4 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6NR8
 | | hTRiC-hPFD Class6 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6NRB
 | | hTRiC-hPFD Class2 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
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6M0R
 | | 2.7A Yeast Vo state3 | | Descriptor: | (6~{E},10~{E},14~{E},18~{E},22~{E},26~{E},30~{R})-2,6,10,14,18,22,26,30-octamethyldotriaconta-2,6,10,14,18,22,26-heptaene, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, PYROPHOSPHATE, ... | | Authors: | Roh, S.H, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, Singharoy, A, Chiu, W. | | Deposit date: | 2020-02-22 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex.
Sci Adv, 6, 2020
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7YCH
 | | Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the first-step self-splicing | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | | Deposit date: | 2022-07-01 | | Release date: | 2023-07-05 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM.
Nucleic Acids Res., 51, 2023
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7YCG
 | | Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the first-step self-splicing | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (393-MER), ... | | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | | Deposit date: | 2022-07-01 | | Release date: | 2023-07-05 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM.
Nucleic Acids Res., 51, 2023
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7WU7
 | | Prefoldin-tubulin-TRiC complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Prefoldin subunit 1, Prefoldin subunit 2, ... | | Authors: | Gestaut, D, Zhao, Y, Park, J, Ma, B, Leitner, A, Collier, M, Pintilie, G, Roh, S.-H, Chiu, W, Frydman, J. | | Deposit date: | 2022-02-07 | | Release date: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7YCI
 | | Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the first-step self-splicing | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (389-MER), ... | | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | | Deposit date: | 2022-07-01 | | Release date: | 2023-07-05 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM.
Nucleic Acids Res., 51, 2023
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7YC8
 | | Cryo-EM structure of Tetrahymena ribozyme conformation 1 undergoing the first-step self-splicing | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, RNA (388-MER) | | Authors: | Zhang, X, Li, S, Pintilie, G, Palo, M.Z, Zhang, K. | | Deposit date: | 2022-07-01 | | Release date: | 2023-07-05 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM.
Nucleic Acids Res., 51, 2023
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7XSL
 | | Misfolded Tetrahymena ribozyme conformation 2 | | Descriptor: | RNA (388-MER) | | Authors: | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | | Deposit date: | 2022-05-14 | | Release date: | 2022-08-03 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSK
 | | Misfolded Tetrahymena ribozyme conformation 1 | | Descriptor: | RNA (388-MER) | | Authors: | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | | Deposit date: | 2022-05-14 | | Release date: | 2022-08-03 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSN
 | | Native Tetrahymena ribozyme conformation | | Descriptor: | RNA (387-MER) | | Authors: | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | | Deposit date: | 2022-05-14 | | Release date: | 2022-08-03 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSM
 | | Misfolded Tetrahymena ribozyme conformation 3 | | Descriptor: | RNA (388-MER) | | Authors: | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | | Deposit date: | 2022-05-14 | | Release date: | 2022-08-03 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
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