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C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1
Descriptor:	ITSM, Tyrosine-protein phosphatase non-receptor type 11
Authors:	Marasco, M.
Deposit date:	2019-03-25
Release date:	2020-02-05
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020

Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
Descriptor:	Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM)
Authors:	Krausze, J, Sikorska, J, Carlomagno, T.
Deposit date:	2019-05-13
Release date:	2020-02-19
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.89 Å)
Cite:	Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020

Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
Descriptor:	Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM)
Authors:	Krausze, J, Sikorska, J, Carlomagno, T.
Deposit date:	2019-05-13
Release date:	2020-02-19
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020

Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide
Descriptor:	Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15
Authors:	Ssebyatika, G, Krey, T.
Deposit date:	2021-03-18
Release date:	2021-06-09
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Plos Pathog., 17, 2021