3KJY
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![BU of 3kjy by Molmil](/molmil-images/mine/3kjy) | Crystal structure of reduced HOMO SAPIENS CLIC3 | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | Authors: | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | Deposit date: | 2009-11-04 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of human CLIC3 at 2 A resolution Proteins, 78, 2010
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5T3N
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![BU of 5t3n by Molmil](/molmil-images/mine/5t3n) | Sp-2Cl-cAMPS bound to PKAR CBD2 | Descriptor: | (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit | Authors: | Littler, D.R, Gilson, P. | Deposit date: | 2016-08-26 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291, 2016
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2H6D
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![BU of 2h6d by Molmil](/molmil-images/mine/2h6d) | Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Authors: | Littler, D.R, Walker, J.R, Wybenga-Groot, L, Newman, E.M, Butler-Cole, C, Mackenzie, F, Finerty, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-05-31 | Release date: | 2006-06-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr.,Sect.F, 66, 2010
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5KBF
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![BU of 5kbf by Molmil](/molmil-images/mine/5kbf) | cAMP bound PfPKA-R (141-441) | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit, putative | Authors: | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | Deposit date: | 2016-06-03 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291, 2016
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5K8S
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![BU of 5k8s by Molmil](/molmil-images/mine/5k8s) | cAMP bound PfPKA-R (297-441) | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit | Authors: | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | Deposit date: | 2016-05-31 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291, 2016
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4Z9C
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![BU of 4z9c by Molmil](/molmil-images/mine/4z9c) | EcPltAB Oxidized | Descriptor: | PHOSPHATE ION, Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein | Authors: | Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T. | Deposit date: | 2015-04-10 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins. J. Biol. Chem., 2017
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4Z9D
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![BU of 4z9d by Molmil](/molmil-images/mine/4z9d) | EcPltA | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin-like subunit ArtA, SODIUM ION | Authors: | Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T. | Deposit date: | 2015-04-10 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins. J. Biol. Chem., 2017
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1RK4
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![BU of 1rk4 by Molmil](/molmil-images/mine/1rk4) | Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1 | Descriptor: | CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1 | Authors: | Littler, D.R, Harrop, S.J, Fairlie, W.D, Brown, L.J, Pankhurst, G.J, Pankhurst, S, DeMaere, M.Z, Campbell, T.J, Bauskin, A.R, Tonini, R, Mazzanti, M, Breit, S.N, Curmi, P.M. | Deposit date: | 2003-11-20 | Release date: | 2003-12-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition J.Biol.Chem., 279, 2004
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2AHE
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![BU of 2ahe by Molmil](/molmil-images/mine/2ahe) | Crystal structure of a soluble form of CLIC4. intercellular chloride ion channel | Descriptor: | Chloride intracellular channel protein 4 | Authors: | Littler, D.R, Assaad, N.N, Harrop, S.J, Brown, L.J, Pankhurst, G.J, Luciani, P, Aguilar, M.-I, Mazzanti, M, Berryman, M.A, Breit, S.N, Curmi, P.M.G. | Deposit date: | 2005-07-28 | Release date: | 2005-08-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. FEBS J., 272, 2005
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6W9Q
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![BU of 6w9q by Molmil](/molmil-images/mine/6w9q) | Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase | Descriptor: | 3C-like proteinase peptide, Non-structural protein 9 fusion, PHOSPHATE ION | Authors: | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | Deposit date: | 2020-03-23 | Release date: | 2020-04-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9. Iscience, 23, 2020
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6WC1
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![BU of 6wc1 by Molmil](/molmil-images/mine/6wc1) | |
6WXD
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![BU of 6wxd by Molmil](/molmil-images/mine/6wxd) | SARS-CoV-2 Nsp9 RNA-replicase | Descriptor: | Non-structural protein 9, SULFATE ION | Authors: | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | Deposit date: | 2020-05-10 | Release date: | 2020-05-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9. Iscience, 23, 2020
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7KRI
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![BU of 7kri by Molmil](/molmil-images/mine/7kri) | FR6-bound SARS-CoV-2 Nsp9 RNA-replicase | Descriptor: | 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ... | Authors: | Littler, D.R, Gully, B.S, Rossjohn, J. | Deposit date: | 2020-11-20 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9. J.Biol.Chem., 297, 2021
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7N3K
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![BU of 7n3k by Molmil](/molmil-images/mine/7n3k) | Oridonin-bound SARS-CoV-2 Nsp9 | Descriptor: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, Non-structural protein 9, SULFATE ION | Authors: | Littler, D.R, Gully, B.S, Rossjohn, J. | Deposit date: | 2021-06-01 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein. J.Biol.Chem., 297, 2021
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3FY7
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![BU of 3fy7 by Molmil](/molmil-images/mine/3fy7) | Crystal structure of homo sapiens CLIC3 | Descriptor: | Chloride intracellular channel protein 3, SULFATE ION | Authors: | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | Deposit date: | 2009-01-22 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of human CLIC3 at 2 A resolution Proteins, 78, 2010
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3G73
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![BU of 3g73 by Molmil](/molmil-images/mine/3g73) | Structure of the FOXM1 DNA binding | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ... | Authors: | Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H. | Deposit date: | 2009-02-09 | Release date: | 2009-03-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence Nucleic Acids Res., 2010
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7SKY
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![BU of 7sky by Molmil](/molmil-images/mine/7sky) | Pertussis toxin S1 bound to NAD+ | Descriptor: | IODIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin subunit 1 | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2021-10-21 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.37000132 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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7SKI
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![BU of 7ski by Molmil](/molmil-images/mine/7ski) | Pertussis toxin in complex with PJ34 | Descriptor: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Pertussis toxin subunit 1 | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2021-10-20 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.09912443 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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7SKK
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![BU of 7skk by Molmil](/molmil-images/mine/7skk) | pertussis toxin in complex with ADPR and Nicotinamide | Descriptor: | NICOTINAMIDE, Pertussis toxin subunit 1, SULFATE ION, ... | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2021-10-21 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65000772 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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7SNE
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![BU of 7sne by Molmil](/molmil-images/mine/7sne) | Pertussis toxin S1 subunit bound to BaAD | Descriptor: | Pertussis toxin subunit 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylanilino)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) | Authors: | Littler, D.R, Beddoe, T. | Deposit date: | 2021-10-28 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.00011 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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7U6Z
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![BU of 7u6z by Molmil](/molmil-images/mine/7u6z) | Pertussis toxin E129D NAD | Descriptor: | IODIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin subunit 1 | Authors: | Littler, D.R, Beddoe, T, Pulliainen, A, Rossjohn, J. | Deposit date: | 2022-03-06 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.30002 Å) | Cite: | Crystal structures of pertussis toxin with NAD + and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. J.Biol.Chem., 298, 2022
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8DQU
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![BU of 8dqu by Molmil](/molmil-images/mine/8dqu) | Nanobody bound SARS-CoV-2 Nsp9 | Descriptor: | Nanobody, Non-structural protein 9 | Authors: | Littler, D.R, Gully, B.S, Rossjohn, J. | Deposit date: | 2022-07-20 | Release date: | 2023-02-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.45003176 Å) | Cite: | Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9. Plos One, 18, 2023
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2FK9
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![BU of 2fk9 by Molmil](/molmil-images/mine/2fk9) | Human protein kinase C, eta | Descriptor: | protein kinase C, eta type | Authors: | Walker, J.R, Littler, D.R, Finerty Jr, P.J, MacKenzie, F, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-01-04 | Release date: | 2006-01-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. Biochem.Biophys.Res.Commun., 349, 2006
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2YV7
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![BU of 2yv7 by Molmil](/molmil-images/mine/2yv7) | |
4L6T
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![BU of 4l6t by Molmil](/molmil-images/mine/4l6t) | GM1 bound form of the ECX AB5 holotoxin | Descriptor: | ECXA, ECXB, ZINC ION, ... | Authors: | Littler, D.R, Ng, N.M, Rossjohn, J, Beddoe, T. | Deposit date: | 2013-06-12 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.859 Å) | Cite: | EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit. Structure, 21, 2013
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