4V3D
| The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | Deposit date: | 2014-10-17 | Release date: | 2014-12-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria. Cell Host Microbe., 17, 2015
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4V3E
| The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | Deposit date: | 2014-10-17 | Release date: | 2014-12-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria. Cell Host Microbe., 17, 2015
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8C3Y
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8C44
| HB3VAR03 apo headstructure (PfEMP1 A) complexed with EPCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Raghavan, S.S.R, Lavstsen, T, Wang, K.T. | Deposit date: | 2022-12-31 | Release date: | 2023-08-16 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1. Structure, 31, 2023
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6SNY
| Synthetic mimic of an EPCR-binding PfEMP1 bound to EPCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, ... | Authors: | Barber, N.M, Higgins, M.K. | Deposit date: | 2019-08-27 | Release date: | 2019-09-04 | Last modified: | 2021-01-20 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein. Msphere, 6, 2021
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7NNH
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7B52
| VAR2CSA full ectodomain | Descriptor: | Erythrocyte membrane protein 1 | Authors: | Wang, K.T, Gourdon, P.E, Dagil, R, Salanti, A. | Deposit date: | 2020-12-03 | Release date: | 2021-04-21 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding. Nat Commun, 12, 2021
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7B54
| VAR2CSA full ectodomain in present of plCS, DBL1-DBL4 | Descriptor: | VAR2CSA in presence of plCS, DBl1-DBL4,Erythrocyte membrane protein 1 | Authors: | Wang, K.T, Dagil, R, Gourdon, P.E, Salanti, A. | Deposit date: | 2020-12-03 | Release date: | 2021-06-02 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding. Nat Commun, 12, 2021
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5LGD
| The CIDRa domain from MCvar1 PfEMP1 bound to CD36 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Hsieh, F.L, Higgins, M.K. | Deposit date: | 2016-07-06 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | The structural basis for CD36 binding by the malaria parasite. Nat Commun, 7, 2016
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7Z12
| VAR2 complex with PAM1.4 | Descriptor: | PAM1.4, Heavy Chain, light Chain, ... | Authors: | Raghavan, S.S.R, Wang, K.T. | Deposit date: | 2022-02-24 | Release date: | 2022-11-02 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA. Plos Pathog., 18, 2022
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7Z1H
| VAR2CSA APO | Descriptor: | VAR2CSA APO | Authors: | Raghavan, S.S.R, Wang, K.T. | Deposit date: | 2022-02-24 | Release date: | 2022-11-02 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA. Plos Pathog., 18, 2022
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5MZA
| The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Erythrocyte membrane protein 1 (PfEMP1), ... | Authors: | Lennartz, F, Higgins, M.K. | Deposit date: | 2017-01-31 | Release date: | 2017-03-22 | Last modified: | 2020-10-07 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell Host Microbe, 21, 2017
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