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2FR0
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BU of 2fr0 by Molmil
The first ketoreductase of the erythromycin synthase (crystal form 1)
Descriptor: Erythromycin synthase, EryAI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2006-01-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
8G4U
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BU of 8g4u by Molmil
Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase
Descriptor: EryAIII
Authors:Keatinge-Clay, A.T.
Deposit date:2023-02-10
Release date:2023-03-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures reveal the framework of cis -acyltransferase modular polyketide synthases.
Biorxiv, 2023
2Z5L
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BU of 2z5l by Molmil
The first ketoreductase of the tylosin PKS
Descriptor: Tylactone synthase starter module and modules 1 & 2
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2007-07-14
Release date:2007-08-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A tylosin ketoreductase reveals how chirality is determined in polyketides
Chem.Biol., 14, 2007
1TQY
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BU of 1tqy by Molmil
The Actinorhodin Ketosynthase/Chain Length Factor
Descriptor: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
Authors:Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
Deposit date:2004-06-18
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
1NM2
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BU of 1nm2 by Molmil
Malonyl-CoA:ACP Transacylase
Descriptor: ACETIC ACID, NICKEL (II) ION, malonyl CoA:acyl carrier protein malonyltransferase
Authors:Keatinge-Clay, A.T, Shelat, A.A, Savage, D.F, Tsai, S, Miercke, L.J.W, O'Connell III, J.D, Khosla, C, Stroud, R.M.
Deposit date:2003-01-08
Release date:2003-01-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
Structure, 11, 2003
2FR1
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BU of 2fr1 by Molmil
The first ketoreductase of the erythromycin synthase (crystal form 2)
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, erythromycin synthase, EryAI
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2006-01-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
5D2E
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BU of 5d2e by Molmil
crystal structure of an N-terminal ketoreductase from macrolactin assembly line
Descriptor: GLYCEROL, MlnE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Keatinge-clay, A.T, Zeng, J.
Deposit date:2015-08-05
Release date:2015-08-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The crystal structure of an N-terminal ketoreductase from macrolactin polyketide synthase
To Be Published
8CZC
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BU of 8czc by Molmil
AT from first module of the pikromycin synthase
Descriptor: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
Authors:Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
Deposit date:2022-05-24
Release date:2022-06-08
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
7UWR
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BU of 7uwr by Molmil
KSQ+AT from first module of the pikromycin synthase
Descriptor: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
Authors:Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
Deposit date:2022-05-03
Release date:2022-06-08
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
5KKU
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BU of 5kku by Molmil
Crystal structure of an N-terminal dehydratase from difficidin assembly line
Descriptor: Polyketide synthase type I
Authors:Keatinge-Clay, A.T, Zeng, J.
Deposit date:2016-06-22
Release date:2016-12-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Dehydratase Provides Insights into Split Bimodules and Polypeptide Docking in trans-AT Polyketide Synthases
To Be Published
6MHP
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BU of 6mhp by Molmil
Crystal structure of BaeC acyltransferase from bacillaene polyketide synthase in Bacillus amyloliquefaciens
Descriptor: Malonyl CoA-acyl carrier protein transacylase
Authors:Meinke, J.L, Keatinge-Clay, A.T.
Deposit date:2018-09-18
Release date:2019-09-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:BaeC crystal structure
To Be Published
4W61
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BU of 4w61 by Molmil
Crystal structure of beta-ketoacyl thiolase B (BktB) from Ralstonia eutropha
Descriptor: Beta-ketothiolase BktB
Authors:Fage, C.D, Keatinge-Clay, A.T.
Deposit date:2014-08-19
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous beta-ketoacyl thiolase fromRalstonia eutropha.
J. Mol. Catal., B Enzym., 121, 2015
4U3V
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BU of 4u3v by Molmil
Crystal structure of the trans-acyltransferase polyketide synthase enoyl-isomerase
Descriptor: Polyketide synthase PksR
Authors:Gay, D.C, Spear, P.J, Keatinge-Clay, A.T.
Deposit date:2014-07-22
Release date:2014-08-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase.
Acs Chem.Biol., 9, 2014
4DIF
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BU of 4dif by Molmil
Structure of A1-type ketoreductase
Descriptor: AmphB, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2012-01-30
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity
To be Published
5KTK
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BU of 5ktk by Molmil
Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase PksJ
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2016-07-11
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
To Be Published
3SLK
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BU of 3slk by Molmil
Structure of ketoreductase and enoylreductase didomain from modular polyketide synthase
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase extender module 2, SULFATE ION
Authors:Zheng, J, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2011-06-24
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Divergence of multimodular polyketide synthases revealed by a didomain structure.
Nat.Chem.Biol., 8, 2012
3QP9
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BU of 3qp9 by Molmil
The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase
Descriptor: Type I polyketide synthase PikAII
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2011-02-11
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases.
J.Mol.Biol., 410, 2011
4IMP
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BU of 4imp by Molmil
The missing linker: a dimerization motif located within polyketide synthase modules
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase extender modules 3-4
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2013-01-03
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The missing linker: a dimerization motif located within polyketide synthase modules.
Acs Chem.Biol., 8, 2013
4J1S
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BU of 4j1s by Molmil
Crystal structure of a ketoreductase domain from the bacillaene assembly line
Descriptor: Polyketide synthase PksJ
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2013-02-01
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective alpha- and beta-ketoreduction.
Proteins, 82, 2014
4J1Q
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BU of 4j1q by Molmil
Crystal structure of a ketoreductase domain from the bacillaene assembly line
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase PksJ
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2013-02-01
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective alpha- and beta-ketoreduction.
Proteins, 82, 2014
6MHK
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BU of 6mhk by Molmil
Crystal structure of ketosynthase nine from bacillaene polyketide synthase in Bacillus amyloliquefaciens
Descriptor: Polyketide synthase
Authors:Meinke, J.L, Keatinge-Clay, A.T.
Deposit date:2018-09-18
Release date:2019-09-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of ketosynthase nine from BaeM
To Be Published
6MHL
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BU of 6mhl by Molmil
Crystal structure of ketosynthase twelve from bacillaene polyketide synthase in Bacillus amyloliquefaciens
Descriptor: Hybrid NRPS/PKS
Authors:Meinke, J.L, Keatinge-Clay, A.T.
Deposit date:2018-09-18
Release date:2019-09-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of ketosynthase twelve from BaeN
To Be Published
3UYL
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BU of 3uyl by Molmil
Spinosyn Rhamnosyltransferase SpnG complexed with thymidine diphosphate
Descriptor: MAGNESIUM ION, NDP-rhamnosyltransferase, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-12-06
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012
3UYK
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BU of 3uyk by Molmil
Spinosyn Rhamnosyltransferase SpnG complexed with spinosyn aglycone
Descriptor: (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-2,13-dihydroxy-14-methyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione, MAGNESIUM ION, NDP-rhamnosyltransferase, ...
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-12-06
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012
3TSA
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BU of 3tsa by Molmil
Spinosyn Rhamnosyltransferase SpnG
Descriptor: MAGNESIUM ION, NDP-rhamnosyltransferase, alpha-D-glucopyranose
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-09-12
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012

 

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