5MAM
 
 | | Human insulin in complex with serotonin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2016-11-03 | | Release date: | 2017-04-05 | | Last modified: | 2017-05-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
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5MT9
 | | Human insulin in complex with serotonin and arginine | | Descriptor: | ARGININE, CHLORIDE ION, Insulin, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2017-01-07 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
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5MT3
 | | Human insulin in complex with serotonin and arginine | | Descriptor: | ARGININE, CHLORIDE ION, Insulin, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2017-01-06 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
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3ZI3
 | | Crystal structure of the B24His-insulin - human analogue | | Descriptor: | INSULIN, SULFATE ION | | Authors: | Zakova, L, Kletvikova, E, Veverka, V, Lepsik, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. | | Deposit date: | 2013-01-02 | | Release date: | 2013-03-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Integrity of the B24 Site in Human Insulin is Important for Hormone Functionality
J.Biol.Chem., 288, 2013
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2N2X
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2N2W
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2N2V
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2M2N
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2M2O
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2M2P
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2M2M
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2MVD
 | | Solution structure of [GlnB22]-insulin mutant at pH 1.9 | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. | | Deposit date: | 2014-10-02 | | Release date: | 2014-12-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young.
Plos One, 9, 2014
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2MPG
 | | Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Kosinova, L, Jiracek, J, Zakova, L, Veverka, V. | | Deposit date: | 2014-05-17 | | Release date: | 2014-06-11 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Biochemistry, 53, 2014
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2MVC
 | | Solution structure of human insulin at pH 1.9 | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. | | Deposit date: | 2014-10-02 | | Release date: | 2014-12-10 | | Last modified: | 2016-06-01 | | Method: | SOLUTION NMR | | Cite: | Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young.
Plos One, 9, 2014
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8TAN
 | | CryoEM structure of MFRV-VILP bound to IGF1Rzip | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ... | | Authors: | Kirk, N.S. | | Deposit date: | 2023-06-27 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab, 80, 2024
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5KQV
 | | Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... | | Authors: | Lawrence, M.C, Smith, B.J, Croll, T.I. | | Deposit date: | 2016-07-06 | | Release date: | 2017-07-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
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3W11
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3W13
 | | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | | Authors: | Lawrence, M.C, Smith, B.J, Brzozowski, A.M. | | Deposit date: | 2012-11-06 | | Release date: | 2013-01-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (4.303 Å) | | Cite: | How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
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3W12
 | | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | | Authors: | Lawrence, M.C, Smith, B.J, Brzozowsk, A.M. | | Deposit date: | 2012-11-06 | | Release date: | 2013-01-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (4.301 Å) | | Cite: | How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
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5L3N
 | | D11 bound [N29, S39_PQ]-IGF-II | | Descriptor: | Insulin-like growth factor II | | Authors: | Hexnerova, R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
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5L3L
 | | D11 bound IGF-II | | Descriptor: | Insulin-like growth factor II | | Authors: | Hexnerova, R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
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5L3M
 | | D11 bound [S39_PQ]-IGF-II | | Descriptor: | Insulin-like growth factor II | | Authors: | Hexnerova, R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
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