3TV0
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4EL9
| Structure of N-terminal kinase domain of RSK2 with afzelin | Descriptor: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Ribosomal protein S6 kinase alpha-3 | Authors: | Utepbergenov, D, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2012-04-10 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor. Biochemistry, 51, 2012
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4TGL
| CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE | Descriptor: | DIETHYL PHOSPHONATE, TRIACYL-GLYCEROL ACYLHYDROLASE | Authors: | Derewenda, U, Brzozowski, A.M, Lawson, D, Derewenda, Z.S. | Deposit date: | 1991-07-29 | Release date: | 1993-07-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase. Biochemistry, 31, 1992
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6B6Z
| Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) | Descriptor: | Apo Fab Heavy Chain, Apo Fab Light Chain, ZINC ION | Authors: | Radwanska, M.J, Derewenda, U, Kossiakoff, A.A, Derewenda, Z.S. | Deposit date: | 2017-10-03 | Release date: | 2018-12-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.112 Å) | Cite: | Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) To Be Published
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5DSD
| The crystal structure of the C-terminal domain of Ebola (Bundibugyo) nucleoprotein | Descriptor: | CHLORIDE ION, GLYCEROL, Nucleoprotein | Authors: | Baker, L, Handing, K.B, Utepbergenov, D, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2015-09-17 | Release date: | 2015-09-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. Acta Crystallogr D Struct Biol, 72, 2016
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5E2X
| The crystal structure of the C-terminal domain of Ebola (Tai Forest) nucleoprotein | Descriptor: | NONAETHYLENE GLYCOL, NP | Authors: | Baker, L.E, Handing, K.B, Derewenda, U, Utepbergenov, D, Derewenda, Z.S. | Deposit date: | 2015-10-01 | Release date: | 2015-10-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. Acta Crystallogr D Struct Biol, 72, 2016
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6TAA
| STRUCTURE AND MOLECULAR MODEL REFINEMENT OF ASPERGILLUS ORYZAE (TAKA) ALPHA-AMYLASE: AN APPLICATION OF THE SIMULATED-ANNEALING METHOD | Descriptor: | ALPHA-AMYLASE, CALCIUM ION | Authors: | Swift, H.J, Brady, L, Derewenda, Z.S, Dodson, E.J, Turkenburg, J.P, Wilkinson, A.J. | Deposit date: | 1992-08-21 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and molecular model refinement of Aspergillus oryzae (TAKA) alpha-amylase: an application of the simulated-annealing method. Acta Crystallogr.,Sect.B, 47, 1991
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4GUE
| Structure of N-terminal kinase domain of RSK2 with flavonoid glycoside quercitrin | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, MAGNESIUM ION, Ribosomal protein S6 kinase alpha-3, ... | Authors: | Derewenda, U, Utepbergenov, D, Szukalska, G, Derewenda, Z.S. | Deposit date: | 2012-08-29 | Release date: | 2013-01-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution. Acta Crystallogr.,Sect.D, 69, 2013
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1F7C
| CRYSTAL STRUCTURE OF THE BH DOMAIN FROM GRAF, THE GTPASE REGULATOR ASSOCIATED WITH FOCAL ADHESION KINASE | Descriptor: | RHOGAP PROTEIN | Authors: | Longenecker, K.L, Derewenda, U, Sheffield, P.J, Zheng, Y, Derewenda, Z.S. | Deposit date: | 2000-06-26 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the BH domain from graf and its implications for Rho GTPase recognition. J.Biol.Chem., 275, 2000
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1MLA
| THE ESCHERICHIA COLI MALONYL-COA:ACYL CARRIER PROTEIN TRANSACYLASE AT 1.5-ANGSTROMS RESOLUTION. CRYSTAL STRUCTURE OF A FATTY ACID SYNTHASE COMPONENT | Descriptor: | MALONYL-COENZYME A ACYL CARRIER PROTEIN TRANSACYLASE | Authors: | Serre, L, Verbree, E.C, Dauter, Z, Stuitje, A.R, Derewenda, Z.S. | Deposit date: | 1995-01-25 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component. J.Biol.Chem., 270, 1995
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2V71
| Coiled-coil region of NudEL | Descriptor: | NUCLEAR DISTRIBUTION PROTEIN NUDE-LIKE 1 | Authors: | Derewenda, U, Cooper, D.R, Kim, M.H, Derewenda, Z.S. | Deposit date: | 2007-07-25 | Release date: | 2007-11-27 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly. Structure, 15, 2007
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4QAZ
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4QB0
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3HD0
| Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima | Descriptor: | Endonuclease V | Authors: | Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | Deposit date: | 2009-05-06 | Release date: | 2009-07-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima To be Published
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1W9E
| Crystal structure of the PDZ tandem of human syntenin in complex with TNEFYF peptide | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEFYF PEPTIDE | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2004-10-09 | Release date: | 2006-03-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins. Biochemistry, 45, 2006
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1W9O
| Crystal structure of the PDZ tandem of human syntenin in complex with TNEYYV peptide | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEYYV PEPTIDE | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2004-10-15 | Release date: | 2006-03-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins. Biochemistry, 45, 2006
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1WAB
| PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Descriptor: | ACETATE ION, PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Authors: | Ho, Y.S, Swenson, L, Derewenda, U, Serre, L, Wei, Y, Dauter, Z, Hattori, M, Aoki, J, Arai, H, Adachi, T, Inoue, K, Derewenda, Z.S. | Deposit date: | 1996-10-30 | Release date: | 1997-11-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. Nature, 385, 1997
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1W9Q
| Crystal structure of the PDZ tandem of human syntenin in complex with TNEFAF peptide | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEFAF PEPTIDE | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, Z.S. | Deposit date: | 2004-10-15 | Release date: | 2006-03-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins. Biochemistry, 45, 2006
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3H3E
| Crystal structure of Tm1679, A METAL-DEPENDENT HYDROLASE OF THE BETA-LACTAMASE SUPERFAMILY | Descriptor: | ZINC ION, uncharacterized protein Tm1679 | Authors: | Cooper, D.R, Olekhnovitch, N, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | Deposit date: | 2009-04-16 | Release date: | 2009-07-14 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.749 Å) | Cite: | Crystal structure of Tm1679, A METAL-DEPENDENT HYDROLASE OF THE BETA-LACTAMASE SUPERFAMILY To be Published
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3TGL
| STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT | Descriptor: | TRIACYL-GLYCEROL ACYLHYDROLASE | Authors: | Brady, L, Brzozowski, A.M, Derewenda, Z.S, Dodson, E.J, Dodson, G.G, Tolley, S.P, Turkenburg, J.P, Christiansen, L, Huge-Jensen, B, Norskov, L, Thim, L. | Deposit date: | 1991-07-29 | Release date: | 1993-07-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT. Acta Crystallogr.,Sect.B, 48, 1992
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1ZNJ
| INSULIN, MONOCLINIC CRYSTAL FORM | Descriptor: | CHLORIDE ION, INSULIN, PHENOL, ... | Authors: | Turkenburg, M.G.W, Whittingham, J.L, Turkenburg, J.P, Dodson, G.G, Derewenda, U, Smith, G.D, Dodson, E.J, Derewenda, Z.S, Xiao, B. | Deposit date: | 1997-09-23 | Release date: | 1998-01-28 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure Determination and Refinement of Two Crystal Forms of Native Insulins To be Published
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2BQQ
| X-ray Structure of the N-terminal Domain of Human Doublecortin | Descriptor: | NEURONAL MIGRATION PROTEIN DOUBLECORTIN | Authors: | Kim, M.H, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2005-04-27 | Release date: | 2006-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Dc-Module of Doublecortin: Dynamics, Domain Boundaries, and Functional Implications. Proteins, 64, 2006
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5TGL
| A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX | Descriptor: | LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER | Authors: | Brzozowski, A.M, Derewenda, U, Derewenda, Z.S, Dodson, G.G, Lawson, D, Turkenburg, J.P, Bjorkling, F, Huge-Jensen, B, Patkar, S.R, Thim, L. | Deposit date: | 1991-10-30 | Release date: | 1994-01-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. Nature, 351, 1991
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3MSX
| Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 20, ... | Authors: | Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2010-04-29 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Mechanism of molecular specificity of RhoGAP domains towards small GTPases of RhoA family. To be Published
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3N77
| Crystal structure of Idp01880, putative NTP pyrophosphohydrolase of Salmonella typhimurium LT2 | Descriptor: | Nucleoside triphosphatase nudI | Authors: | Frydrysiak, J, Cooper, D.R, Derewenda, U, Anderson, W.F, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI), Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2010-05-26 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of Idp01880, putative NTP pyrophosphohydrolase of Salmonella typhimurium LT2 To be Published
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