5ONM
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![BU of 5onm by Molmil](/molmil-images/mine/5onm) | Crystal Structure of Ectoine Synthase from P. lautus | Descriptor: | FE (III) ION, L-ectoine synthase, SULFATE ION | Authors: | Bremer, E. | Deposit date: | 2017-08-04 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. Sci Rep, 9, 2019
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5ONN
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![BU of 5onn by Molmil](/molmil-images/mine/5onn) | Crystal Structure of Ectoine Synthase from P. lautus | Descriptor: | (2~{S})-4-acetamido-2-azanyl-butanoic acid, FE (III) ION, L-ectoine synthase | Authors: | Bremer, E. | Deposit date: | 2017-08-04 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. Sci Rep, 9, 2019
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5ONO
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![BU of 5ono by Molmil](/molmil-images/mine/5ono) | Crystal Structure of Ectoine Synthase from P. lautus | Descriptor: | (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, FE (III) ION, L-ectoine synthase | Authors: | Bremer, E. | Deposit date: | 2017-08-04 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. Sci Rep, 9, 2019
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4NMI
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![BU of 4nmi by Molmil](/molmil-images/mine/4nmi) | |
3HCQ
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![BU of 3hcq by Molmil](/molmil-images/mine/3hcq) | Structural analysis of the choline binding protein ChoX in a semi-closed and ligand-free conformation | Descriptor: | Putative choline ABC transporter, periplasmic solute-binding component | Authors: | Oswald, C, Smits, S.H.J, Hoeing, M, Bremer, E, Schmitt, L. | Deposit date: | 2009-05-06 | Release date: | 2009-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structural analysis of the choline-binding protein ChoX in a semi-closed and ligand-free conformation. Biol.Chem., 390, 2009
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3MAM
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![BU of 3mam by Molmil](/molmil-images/mine/3mam) | A molecular switch changes the low to the high affinity state in the substrate binding protein AfProX | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Osmoprotection protein (ProX), ... | Authors: | Tschapek, B, Pittelkow, M, Bremer, E, Schmitt, L, Smits, S.H. | Deposit date: | 2010-03-24 | Release date: | 2011-04-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Arg149 Is Involved in Switching the Low Affinity, Open State of the Binding Protein AfProX into Its High Affinity, Closed State. J.Mol.Biol., 411, 2011
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3R6U
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![BU of 3r6u by Molmil](/molmil-images/mine/3r6u) | Crystal structure of choline binding protein OpuBC from Bacillus subtilis | Descriptor: | CHOLINE ION, Choline-binding protein | Authors: | Pittelkow, M, Tschapek, B, Smits, S.H.J, Schmitt, L, Bremer, E. | Deposit date: | 2011-03-22 | Release date: | 2011-06-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | The Crystal Structure of the Substrate-Binding Protein OpuBC from Bacillus subtilis in Complex with Choline. J.Mol.Biol., 411, 2011
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5NXY
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![BU of 5nxy by Molmil](/molmil-images/mine/5nxy) | Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine | Descriptor: | 1,2-ETHANEDIOL, 2-(trimethyl-lambda~5~-arsanyl)ethanol, Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC | Authors: | Hofmann, T, Bremer, E, Schmitt, L, Smits, S. | Deposit date: | 2017-05-11 | Release date: | 2018-03-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Arsenobetaine: an ecophysiologically important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes. Environ. Microbiol., 20, 2018
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5NXX
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![BU of 5nxx by Molmil](/molmil-images/mine/5nxx) | Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine | Descriptor: | (trimethylarsonio)acetate, Glycine betaine ABC transport system glycine betaine-binding protein OpuAC | Authors: | Hofmann, T, Bremer, E, Schmitt, L, Smits, S. | Deposit date: | 2017-05-11 | Release date: | 2018-03-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Arsenobetaine: an ecophysiologically important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes. Environ. Microbiol., 20, 2018
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4Q5O
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![BU of 4q5o by Molmil](/molmil-images/mine/4q5o) | Crystal structure of EctD from S. alaskensis with 2-oxoglutarate and 5-hydroxyectoine | Descriptor: | (4S,5S)-5-HYDROXY-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-OXOGLUTARIC ACID, Ectoine hydroxylase, ... | Authors: | Hoeppner, A, Widderich, N, Bremer, E, Smits, S.H. | Deposit date: | 2014-04-17 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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4MHU
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![BU of 4mhu by Molmil](/molmil-images/mine/4mhu) | Crystal structure of EctD from S. alaskensis with bound Fe | Descriptor: | Ectoine hydroxylase, FE (III) ION, N-DODECYL-N,N-DIMETHYLGLYCINATE | Authors: | Widderich, N, Hoeppner, A, Pittelkow, M, Heider, J, Smits, S.H, Bremer, E. | Deposit date: | 2013-08-30 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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4MHR
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![BU of 4mhr by Molmil](/molmil-images/mine/4mhr) | Crystal structure of EctD from S. alaskensis in its apoform | Descriptor: | Ectoine hydroxylase | Authors: | Widderich, N, Hoeppner, A, Pittelkow, M, Heider, J, Smits, S.H, Bremer, E. | Deposit date: | 2013-08-30 | Release date: | 2014-09-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J.Biol.Chem., 289, 2014
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2B4M
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![BU of 2b4m by Molmil](/molmil-images/mine/2b4m) | Crystal structure of the binding protein OpuAC in complex with proline betaine | Descriptor: | 1,1-DIMETHYL-PROLINIUM, Glycine betaine-binding protein | Authors: | Horn, C, Sohn-Boesser, L, Breed, J, Welte, W, Schmitt, L, Bremer, E. | Deposit date: | 2005-09-26 | Release date: | 2006-03-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular Determinants for Substrate Specificity of the Ligand-binding Protein OpuAC from Bacillus subtilis for the Compatible Solutes Glycine Betaine and Proline Betaine. J.Mol.Biol., 357, 2006
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2B4L
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![BU of 2b4l by Molmil](/molmil-images/mine/2b4l) | Crystal structure of the binding protein OpuAC in complex with glycine betaine | Descriptor: | 1,2-ETHANEDIOL, Glycine betaine-binding protein, TRIMETHYL GLYCINE | Authors: | Horn, C, Sohn-Boesser, L, Breed, J, Welte, W, Schmitt, L, Bremer, E. | Deposit date: | 2005-09-26 | Release date: | 2006-03-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular Determinants for Substrate Specificity of the Ligand-binding Protein OpuAC from Bacillus subtilis for the Compatible Solutes Glycine Betaine and Proline Betaine. J.Mol.Biol., 357, 2006
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5BY5
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![BU of 5by5 by Molmil](/molmil-images/mine/5by5) | High resolution structure of the ectoine synthase from the cold-adapted marine bacterium Sphingopyxis alaskensis | Descriptor: | L-ectoine synthase, S-1,2-PROPANEDIOL | Authors: | Widderich, N, Kobus, S, Hoeppner, A, Bremer, E, Smits, S.H.J. | Deposit date: | 2015-06-10 | Release date: | 2016-04-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Biochemistry and Crystal Structure of Ectoine Synthase: A Metal-Containing Member of the Cupin Superfamily. Plos One, 11, 2016
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5BXX
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![BU of 5bxx by Molmil](/molmil-images/mine/5bxx) | Crystal structure of the ectoine synthase from the cold-adapted marine bacterium Sphingopyxis alaskensis | Descriptor: | L-ectoine synthase | Authors: | Widderich, N, Kobus, S, Hoeppner, A, Bremer, E, Smits, S.H.J. | Deposit date: | 2015-06-09 | Release date: | 2016-04-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemistry and Crystal Structure of Ectoine Synthase: A Metal-Containing Member of the Cupin Superfamily. Plos One, 11, 2016
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3CHG
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![BU of 3chg by Molmil](/molmil-images/mine/3chg) | The compatible solute-binding protein OpuAC from Bacillus subtilis in complex with DMSA | Descriptor: | (dimethyl-lambda~4~-sulfanyl)acetic acid, Glycine betaine-binding protein | Authors: | Smits, S.H.J, Hoing, M, Lecher, J, Jebbar, M, Schmitt, L, Bremer, E. | Deposit date: | 2008-03-09 | Release date: | 2008-08-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Compatible-Solute-Binding Protein OpuAC from Bacillus subtilis: Ligand Binding, Site-Directed Mutagenesis, and Crystallographic Studies J.Bacteriol., 190, 2008
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3FXB
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![BU of 3fxb by Molmil](/molmil-images/mine/3fxb) | Crystal structure of the ectoine-binding protein UehA | Descriptor: | (4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, TRAP dicarboxylate transporter, DctP subunit | Authors: | Lecher, J, Pittelkow, M, Bursy, J, Smits, S.H.J, Schmitt, L, Bremer, E. | Deposit date: | 2009-01-20 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of UehA in complex with ectoine-A comparison with other TRAP-T binding proteins. J.Mol.Biol., 389, 2009
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2REG
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![BU of 2reg by Molmil](/molmil-images/mine/2reg) | ABC-transporter choline binding protein in complex with choline | Descriptor: | CHOLINE ION, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN | Authors: | Oswald, C, Schimtt, L, Smits, S.H.J, Hoeing, M, Sohn-Boeser, L, Bremer, E. | Deposit date: | 2007-09-26 | Release date: | 2008-09-16 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of the choline/acetylcholine substrate-binding protein ChoX from Sinorhizobium meliloti in the liganded and unliganded-closed states. J.Biol.Chem., 283, 2008
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2REJ
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![BU of 2rej by Molmil](/molmil-images/mine/2rej) | ABC-transporter choline binding protein in unliganded semi-closed conformation | Descriptor: | PUTATIVE GLYCINE BETAINE ABC TRANSPORTER PROTEIN | Authors: | Oswald, C, Smits, S.H.J, Hoeing, M, Sohn-Boeser, L, Le Rudulier, D, Schmitt, L, Bremer, E. | Deposit date: | 2007-09-26 | Release date: | 2008-09-16 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the choline/acetylcholine substrate-binding protein ChoX from Sinorhizobium meliloti in the liganded and unliganded-closed states. J.Biol.Chem., 283, 2008
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2RF1
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![BU of 2rf1 by Molmil](/molmil-images/mine/2rf1) | Crystal structure of ChoX in an unliganded closed conformation | Descriptor: | PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN | Authors: | Oswald, C, Smits, S.H.J, Hoeing, M, Sohn-Boeser, L, Le Rudulier, D, Schmitt, L, Bremer, E. | Deposit date: | 2007-09-27 | Release date: | 2008-09-16 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the choline/acetylcholine substrate-binding protein ChoX from Sinorhizobium meliloti in the liganded and unliganded-closed states. J.Biol.Chem., 283, 2008
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2RIN
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![BU of 2rin by Molmil](/molmil-images/mine/2rin) | ABC-transporter choline binding protein in complex with acetylcholine | Descriptor: | ACETYLCHOLINE, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN | Authors: | Oswald, C, Smits, S.H.J, Hoeing, M, Sohn-Boeser, L, Le Rudulier, D, Schmitt, L, Bremer, E. | Deposit date: | 2007-10-12 | Release date: | 2008-09-30 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of the choline/acetylcholine substrate-binding protein ChoX from Sinorhizobium meliloti in the liganded and unliganded-closed states. J.Biol.Chem., 283, 2008
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6EYL
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![BU of 6eyl by Molmil](/molmil-images/mine/6eyl) | Crystal structure of OpuBC in complex with carnitine | Descriptor: | CARNITINE, Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Sschmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Reprogramming the substrate specificity of an ABC import system by a single amino acid substitution in its cognate ligand binding protein To Be Published
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6EYG
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![BU of 6eyg by Molmil](/molmil-images/mine/6eyg) | Structure of a OpuBC mutant with bound Glycine betaine | Descriptor: | Osmotically activated L-carnitine/choline ABC transporter substrate-binding protein OpuCC, TRIMETHYL GLYCINE | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Schmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structure of a OpuBC mutant with bound Glycine betaine To Be Published
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6EYQ
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![BU of 6eyq by Molmil](/molmil-images/mine/6eyq) | Crystal structure of a mutated OpuBC in complex with choline | Descriptor: | CHOLINE ION, Choline-binding protein | Authors: | Peherstorfer, S, Teichmann, L, Smits, S.H, Schmitt, L, Bremer, E. | Deposit date: | 2017-11-13 | Release date: | 2018-11-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of a mutated OpuBC in complex with choline To Be Published
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