7S4F
| Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... | Authors: | Brandao, T.A.S, Hengge, A.C, Johnson, S.J. | Deposit date: | 2021-09-08 | Release date: | 2022-09-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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3I7Z
| Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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3I80
| Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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3QKQ
| Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2011-02-01 | Release date: | 2012-08-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
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3QKP
| Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2011-02-01 | Release date: | 2012-08-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
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3F99
| W354F Yersinia enterocolitica PTPase apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH | Authors: | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | Deposit date: | 2008-11-13 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
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3F9A
| W354F Yersinia enterocolitica PTPase complexed with tungstate | Descriptor: | TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH | Authors: | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | Deposit date: | 2008-11-13 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
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3F9B
| W354F Yersinia enterocolitica PTPase complexed with divanadate | Descriptor: | Divanadate ion, GLYCEROL, Tyrosine-protein phosphatase yopH, ... | Authors: | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | Deposit date: | 2008-11-13 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
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6BZ5
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6XEG
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEA
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XE8
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XED
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEF
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.048 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEE
| Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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