1VRR
| Crystal structure of the restriction endonuclease BstYI complex with DNA | Descriptor: | 5'-D(*TP*TP*AP*TP*AP*GP*AP*TP*CP*TP*AP*TP*AP*A)-3', BstYI | Authors: | Townson, S.A, Samuelson, J.C, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2005-06-02 | Release date: | 2005-06-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Implications for Switching Restriction Enzyme Specificities from the Structure of BstYI Bound to a BglII DNA Sequence. Structure, 13, 2005
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2ALZ
| Ternary Complex of hPoli with DNA and dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2005-08-08 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human DNA Polymerase iota Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair. Structure, 13, 2005
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2AQ4
| Ternary complex of the catalytic core of REV1 with DNA and dCTP. | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*C)-3', 5'-D(*TP*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3', ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2005-08-17 | Release date: | 2005-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science, 309, 2005
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3BJY
| Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DAP*DTP*DCP*DCP*DTP*DCP*DCP*DCP*DCP*DTP*DAP*(DOC))-3'), DNA (5'-D(*DTP*DAP*DAP*(P)P*DGP*DTP*DAP*DGP*DGP*DGP*DGP*DAP*DGP*DGP*DAP*DT)-3'), ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2007-12-05 | Release date: | 2008-10-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase Structure, 16, 2008
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3BSB
| Crystal Structure of Human Pumilio1 in Complex with CyclinB reverse RNA | Descriptor: | 5'-R(*UP*UP*UP*AP*AP*UP*GP*UP*U)-3', Pumilio homolog 1 | Authors: | Gupta, Y.K, Nair, D.T, Wharton, R.P, Aggarwal, A.K. | Deposit date: | 2007-12-23 | Release date: | 2008-04-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure, 16, 2008
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3BSX
| Crystal Structure of Human Pumilio 1 in complex with Puf5 RNA | Descriptor: | 5'-R(*UP*UP*GP*UP*AP*AP*UP*AP*UP*UP*A)-3', Pumilio homolog 1 | Authors: | Gupta, Y.K, Nair, D.T, Wharton, R.P, Aggarwal, A.K. | Deposit date: | 2007-12-26 | Release date: | 2008-04-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure, 16, 2008
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6P1H
| Cryo-EM Structure of DNA Polymerase Delta Holoenzyme | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... | Authors: | Jain, R, Rice, W, Aggarwal, A.K. | Deposit date: | 2019-05-19 | Release date: | 2019-10-02 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure and dynamics of eukaryotic DNA polymerase delta holoenzyme. Nat.Struct.Mol.Biol., 26, 2019
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6Q02
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6PZ3
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1B8I
| STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX | Descriptor: | DNA (5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3'), PROTEIN (HOMEOBOX PROTEIN EXTRADENTICLE), ... | Authors: | Passner, J.M, Ryoo, H.-D, Shen, L, Mann, R.S, Aggarwal, A.K. | Deposit date: | 1999-02-01 | Release date: | 1999-04-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature, 397, 1999
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1AU7
| PIT-1 MUTANT/DNA COMPLEX | Descriptor: | CONSENSUS DNA 25-MER, DNA (5'-D(*CP*TP*TP*CP*CP*TP*CP*AP*TP*GP*TP*AP*TP*AP*TP*AP*C P*AP*TP*GP*AP*GP* GP*A)-3'), PROTEIN PIT-1 | Authors: | Jacobson, E.M, Li, P, Leon-Del-Rio, A, Rosenfeld, M.G, Aggarwal, A.K. | Deposit date: | 1997-09-12 | Release date: | 1998-01-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev., 11, 1997
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1D2I
| CRYSTAL STRUCTURE OF RESTRICTION ENDONUCLEASE BGLII COMPLEXED WITH DNA 16-MER | Descriptor: | DNA (5'-D(*TP*AP*TP*TP*AP*TP*AP*GP*AP*TP*CP*TP*AP*TP*AP*A)-3'), MAGNESIUM ION, PROTEIN (RESTRICTION ENDONUCLEASE BGLII) | Authors: | Lukacs, C.M, Kucera, R, Schildkraut, I, Aggarwal, A.K. | Deposit date: | 1999-09-23 | Release date: | 2000-02-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat.Struct.Biol., 7, 2000
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1DFM
| Crystal structure of restriction endonuclease BGLII complexed with DNA 16-mer | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*AP*TP*TP*AP*TP*AP*GP*AP*TP*CP*TP*AP*TP*AP*A)-3'), ENDONUCLEASE BGLII | Authors: | Lukacs, C.M, Kucera, R, Schildkraut, I, Aggarwal, A.K. | Deposit date: | 1999-12-06 | Release date: | 2000-02-21 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat.Struct.Biol., 7, 2000
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1JIH
| Yeast DNA Polymerase ETA | Descriptor: | DNA Polymerase ETA | Authors: | Trincao, J, Johnson, R.E, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2001-07-02 | Release date: | 2002-01-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis Mol.Cell, 8, 2001
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1MX3
| Crystal structure of CtBP dehydrogenase core holo form | Descriptor: | ACETIC ACID, C-terminal binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kumar, V, Carlson, J.E, Ohgi, K.E, Edwards, T.E, Rose, D.W, Escalante, C.R, Aggarwal, A.K. | Deposit date: | 2002-10-01 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Transcription Corepressor CtBP Is an NAD+-Regulated Dehydrogenase Mol.Cell, 10, 2002
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1N72
| Structure and Ligand of a Histone Acetyltransferase Bromodomain | Descriptor: | HISTONE ACETYLTRANSFERASE | Authors: | Dhalluin, C, Carlson, J.E, Zeng, L, He, C, Aggarwal, A.K, Zhou, M.-M. | Deposit date: | 2002-11-12 | Release date: | 2002-12-11 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Structure and Ligand of a Histone Acetyltransferase Bromodomain Nature, 399, 1999
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1OXJ
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2FOK
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2I9T
| Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter | Descriptor: | 5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*TP*CP*TP*G)-3', 5'-D(*CP*AP*GP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*CP*AP*CP*T)-3', Nuclear factor NF-kappa-B p105 subunit, ... | Authors: | Escalante, C.R, Shen, L, Thanos, D, Aggarwal, A.K. | Deposit date: | 2006-09-06 | Release date: | 2007-02-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter Structure, 10, 2002
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5HR4
| Structure of Type IIL restriction-modification enzyme MmeI in complex with DNA has implications for engineering of new specificities | Descriptor: | CALCIUM ION, DNA (5'-D(P*GP*TP*TP*AP*TP*GP*TP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(P*TP*AP*TP*CP*CP*GP*AP*CP*AP*TP*AP*AP*C)-3'), ... | Authors: | Callahan, S.J, Luyten, Y.A, Gupta, Y.K, Wilson, G.G, Roberts, R.J, Morgan, R.D, Aggarwal, A.K. | Deposit date: | 2016-01-22 | Release date: | 2016-04-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5964 Å) | Cite: | Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. Plos Biol., 14, 2016
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5IUD
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5J18
| Solution structure of Ras Binding Domain (RBD) of B-Raf complexed with Rigosertib (Complex I) | Descriptor: | N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, Serine/threonine-protein kinase B-raf | Authors: | Dutta, K, Vasquez-Del Carpio, R, Aggarwal, A.K, Reddy, E.P. | Deposit date: | 2016-03-29 | Release date: | 2016-05-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell, 165, 2016
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5J2R
| Solution structure of Ras Binding Domain (RBD) of B-Raf | Descriptor: | N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, Serine/threonine-protein kinase B-raf | Authors: | Dutta, K, Vasquez-Del Carpio, R, Aggarwal, A.K, Reddy, E.P. | Deposit date: | 2016-03-29 | Release date: | 2016-05-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell, 165, 2016
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2OH2
| Ternary Complex of Human DNA Polymerase | Descriptor: | 5'-D(*GP*GP*G*GP*GP*AP*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*TP*T*CP*CP*AP*GP*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase kappa, ... | Authors: | Lone, S, Townson, S.A, Uljon, S.N, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2007-01-09 | Release date: | 2007-02-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Ternary complex of the catalytic core of human DNA polymerase Kappa with DNA and dTT To be Published
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1Q7F
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