8IY0
| Structure of Acb2 complexed with cAAA | Descriptor: | [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, p26 | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8J8O
| Structure of Acb2 complexed with 2',3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, cGAMP, ... | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-05-02 | Release date: | 2024-02-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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7L7B
| Clostridioides difficile RNAP with fidaxomicin | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | Deposit date: | 2020-12-28 | Release date: | 2022-02-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
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4RZI
| Crystal structure of PhaB from Synechocystis sp. PCC 6803 | Descriptor: | 3-ketoacyl-acyl carrier protein reductase | Authors: | Xue, S, Liu, Y. | Deposit date: | 2014-12-22 | Release date: | 2015-09-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.891 Å) | Cite: | Structure-directed construction of a high-performance version of the enzyme FabG from the photosynthetic microorganism Synechocystis sp. PCC 6803. Febs Lett., 589, 2015
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4RR5
| The crystal structure of Synechocystis sp. PCC 6803 Malonyl-CoA: ACP Transacylase | Descriptor: | ACETATE ION, Malonyl CoA-acyl carrier protein transacylase | Authors: | Liu, Y. | Deposit date: | 2014-11-06 | Release date: | 2015-07-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.427 Å) | Cite: | Structural and biochemical characterization of MCAT from photosynthetic microorganism Synechocystis sp. PCC 6803 reveal its stepwise catalytic mechanism Biochem.Biophys.Res.Commun., 457, 2015
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4XVQ
| H-Ras Y137E | Descriptor: | GLYCEROL, GTPase HRas, MAGNESIUM ION, ... | Authors: | Johnson, C.W, Mattos, C. | Deposit date: | 2015-01-27 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.887 Å) | Cite: | Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
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5TIW
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5TA8
| Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor | Descriptor: | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK1, ZINC ION | Authors: | Skene, R.J, Hosfield, D.J. | Deposit date: | 2016-09-09 | Release date: | 2017-02-22 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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5TA6
| Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor. | Descriptor: | 4-{[(6R)-7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK1, ZINC ION | Authors: | Skene, R.J, Hosfield, D.J. | Deposit date: | 2016-09-09 | Release date: | 2017-02-22 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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8X6B
| Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nectin-2, Transmembrane protein PVRIG | Authors: | Hu, S.T, Han, P, Wang, H, Qi, J.X. | Deposit date: | 2023-11-21 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure, 2024
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6EE9
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6KYF
| Crystal structure of an anti-CRISPR protein | Descriptor: | AcrF11, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Niu, Y, Wang, H, Zhang, Y, Feng, Y. | Deposit date: | 2019-09-18 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Mol.Cell, 80, 2020
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5JZV
| The structure of D77G hCINAP-ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase isoenzyme 6 | Authors: | Liu, Y, Yang, Z, Yang, Y, Cai, X, Zheng, X. | Deposit date: | 2016-05-17 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun, 7, 2016
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6KXG
| Crystal structure of caspase-11-CARD | Descriptor: | caspase-11-CARD | Authors: | Liu, M.Z.Y, Jin, T.C. | Deposit date: | 2019-09-11 | Release date: | 2020-09-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. Cell Discov, 6, 2020
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8SBG
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8SIJ
| Crystal structure of F. varium tryptophanase | Descriptor: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Tryptophanase 1, ... | Authors: | Graboski, A.L, Redinbo, M.R. | Deposit date: | 2023-04-16 | Release date: | 2023-08-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol, 30, 2023
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8SL7
| Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05 | Descriptor: | (E)-3-[(3S)-3-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, Tryptophanase | Authors: | Graboski, A.L, Redinbo, M.R. | Deposit date: | 2023-04-21 | Release date: | 2023-08-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol, 30, 2023
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6UUY
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6UUX
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5GPP
| Crystal structure of zebrafish ASC PYD domain | Descriptor: | ACETATE ION, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, ... | Authors: | Jin, T, Li, Y. | Deposit date: | 2016-08-04 | Release date: | 2017-08-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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5GPQ
| Crystal Structure of zebrafish ASC CARD Domain | Descriptor: | CITRIC ACID, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Jin, T, Li, Y. | Deposit date: | 2016-08-04 | Release date: | 2017-08-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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7MW8
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7N1S
| Crystal Structure Analysis of Xac Nucleotide Pyrophosphatase/Phosphodiesterase | Descriptor: | Phosphodiesterase-nucleotide pyrophosphatase, TETRAETHYLENE GLYCOL, ZINC ION | Authors: | Fernandez, D, Li, L, Brown, J.A, Carozza, J.A. | Deposit date: | 2021-05-28 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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4XVR
| H-Ras Y137F | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Johnson, C.W, Mattos, C. | Deposit date: | 2015-01-27 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.031 Å) | Cite: | Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
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3GQF
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