7XSP
| Structure of gRAMP-target RNA | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | Authors: | Feng, Y, Zhang, L.X. | Deposit date: | 2022-05-15 | Release date: | 2022-11-09 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense. Mol.Cell, 82, 2022
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7XSO
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5Y5P
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5ZTH
| Crystal structure of spRlmCD with U1939loop RNA at 3.24 angstrom | Descriptor: | RNA (5'-R(P*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | Authors: | Jiang, Y.Y, Yu, H.L. | Deposit date: | 2018-05-03 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018
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5Y5Q
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7EVR
| Crystal structure of hnRNP L RRM2 in complex with SETD2 | Descriptor: | Heterogeneous nuclear ribonucleoprotein L, SHI domain from Histone-lysine N-methyltransferase SETD2 | Authors: | Li, F.D, Wang, S.M. | Deposit date: | 2021-05-22 | Release date: | 2021-10-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing. Nat Commun, 12, 2021
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7EVS
| Crystal structure of hnRNP LL RRM2 in complex with SETD2 | Descriptor: | Heterogeneous nuclear ribonucleoprotein L-like, SHI domain from Histone-lysine N-methyltransferase SETD2, SULFATE ION | Authors: | Li, F.D, Wang, S.M. | Deposit date: | 2021-05-22 | Release date: | 2021-10-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing. Nat Commun, 12, 2021
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8IPI
| The apo structure of human mitochondrial methyltransferase METTL15 | Descriptor: | 12S rRNA N4-methylcytidine (m4C) methyltransferase | Authors: | Lv, M.Q, Zhou, W.W. | Deposit date: | 2023-03-14 | Release date: | 2024-01-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15. Cell Discov, 10, 2024
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8IPL
| The structure of human mitochondrial methyltransferase METTL15 with RBFA and SAM | Descriptor: | 12S rRNA N4-methylcytidine (m4C) methyltransferase, Putative ribosome-binding factor A, mitochondrial, ... | Authors: | Lv, M.Q, Zhou, W.W. | Deposit date: | 2023-03-14 | Release date: | 2024-01-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15. Cell Discov, 10, 2024
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8IPM
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8IPK
| The structure of human mitochondrial methyltransferase METTL15 with SAM | Descriptor: | 12S rRNA N4-methylcytidine (m4C) methyltransferase, GLYCEROL, S-ADENOSYLMETHIONINE | Authors: | Lv, M.Q, Zhou, W.W. | Deposit date: | 2023-03-14 | Release date: | 2024-01-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15. Cell Discov, 10, 2024
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7ENQ
| Crystal structure of human NAMPT in complex with compound NAT | Descriptor: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | Deposit date: | 2021-04-19 | Release date: | 2022-05-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.204966 Å) | Cite: | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32, 2022
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7XPR
| Crystal structrue of SeMet-MtdL:GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPS
| Crystal structrue of MtdL:GDP:Mn | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPU
| crystal structure of MtdL-S228A-His soaked GDP-Fucp and Mn | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, MANGANESE (II) ION, ... | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPT
| Crystal structrue of MtdL:GDP:Mn soaked with GDP-Glc | Descriptor: | GDP-ALPHA-D-GLUCOSE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPV
| crysteal structure of MtdL-S228A-His soaked with GDP-Fucf and Mn | Descriptor: | MANGANESE (II) ION, Transglycosylse, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{S},3~{S},4~{S},5~{R})-3,4-bis(oxidanyl)-5-[(1~{S})-1-oxidanylethyl]oxolan-2-yl] hydrogen phosphate | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7DTK
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7DTJ
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6LAU
| the wildtype SAM-VI riboswitch bound to SAH | Descriptor: | CESIUM ION, GUANOSINE-5'-TRIPHOSPHATE, RNA (54-MER), ... | Authors: | Ren, A, Sun, A. | Deposit date: | 2019-11-13 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.109 Å) | Cite: | SAM-VI riboswitch structure and signature for ligand discrimination. Nat Commun, 10, 2019
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6L2T
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6I8L
| Crystal structure of Spindlin1 in complex with the inhibitor TD001851a | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine, ... | Authors: | Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | Deposit date: | 2018-11-20 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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6LAX
| the mutant SAM-VI riboswitch (U6C) bound to SAM | Descriptor: | RNA (55-MER), S-ADENOSYLMETHIONINE, U1 small nuclear ribonucleoprotein A | Authors: | Sun, A, Ren, A. | Deposit date: | 2019-11-13 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SAM-VI riboswitch structure and signature for ligand discrimination. Nat Commun, 10, 2019
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6I8B
| Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn | Descriptor: | 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, GLYCINE, ... | Authors: | Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | Deposit date: | 2018-11-19 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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6L3F
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