4K1F
| Crystal structure of reduced tryparedoxin peroxidase from leishmania major at 2.34 A resolution | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ilari, A, Fiorillo, A, Di Chiaro, F. | Deposit date: | 2013-04-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking Sci Rep, 5, 2015
|
|
1UX8
| X-ray structure of truncated oxygen-avid haemoglobin from Bacillus subtilis | Descriptor: | CHLORIDE ION, CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Ilari, A, Giangiacomo, L, Boffi, A, Chiancone, E. | Deposit date: | 2004-02-20 | Release date: | 2004-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Truncated Oxygen-Avid Hemoglobin from Bacillus Subtilis: X-Ray Structure and Ligand Binding Properties J.Biol.Chem., 280, 2005
|
|
1UVH
| X-ray structure of Dps from Mycobacterium smegmatis | Descriptor: | FE (III) ION, STARVATION-INDUCED DNA PROTECTING PROTEIN | Authors: | Ilari, A, Ceci, P, Falvo, E, Chiancone, E. | Deposit date: | 2004-01-20 | Release date: | 2005-02-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Reassessment of Protein Stability, DNA Binding, and Protection of Mycobacterium Smegmatis Dps. J.Biol.Chem., 280, 2005
|
|
2YAU
| X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin | Descriptor: | 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Baiocco, P, Ilari, A, Colotti, G. | Deposit date: | 2011-02-24 | Release date: | 2012-01-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition. Amino Acids, 42, 2012
|
|
2XH8
| X-ray structure of 119-141 ZnuA deletion mutant from Salmonella enterica. | Descriptor: | SODIUM ION, SULFATE ION, ZINC ABC TRANSPORTER, ... | Authors: | Alaleona, F, Ilari, A, Battistoni, A, Petrarca, P, Chiancone, E. | Deposit date: | 2010-06-09 | Release date: | 2011-04-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The X-Ray Structure of the Zinc Transporter Znua from Salmonella Enterica Discloses a Unique Triad of Zinc Coordinating Histidines. J.Mol.Biol., 409, 2011
|
|
2XY4
| X-RAY STRUCTURE OF ZNUA-WT FROM SALMONELLA ENTERICA | Descriptor: | SULFATE ION, TRIETHYLENE GLYCOL, ZINC ABC TRANSPORTER, ... | Authors: | Alaleona, F, Ilari, A, Battistoni, A, Petrarca, P, Chiancone, E. | Deposit date: | 2010-11-15 | Release date: | 2011-04-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | The X-Ray Structure of the Zinc Transporter Znua from Salmonella Enterica Discloses a Unique Triad of Zinc Coordinating Histidines. J.Mol.Biol., 409, 2011
|
|
2XQV
| The X-ray structure of the Zn(II) bound ZnuA from Salmonella enterica | Descriptor: | SULFATE ION, ZINC ABC TRANSPORTER, PERIPLASMIC ZINC-BINDING PROTEIN, ... | Authors: | Alaleona, F, Ilari, A, Chiancone, E, Battistoni, A, Petrarca, P. | Deposit date: | 2010-09-07 | Release date: | 2011-04-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | The X-Ray Structure of the Zinc Transporter Znua from Salmonella Enterica Discloses a Unique Triad of Zinc Coordinating Histidines. J.Mol.Biol., 409, 2011
|
|
2BMM
| X-ray structure of a novel thermostable hemoglobin from the actinobacterium Thermobifida fusca | Descriptor: | ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, THERMOSTABLE HEMOGLOBIN FROM THERMOBIFIDA FUSCA | Authors: | Ilari, A, Franceschini, S, Bonamore, A, Boffi, A. | Deposit date: | 2005-03-15 | Release date: | 2005-07-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | A Novel Thermostable Hemoglobin from the Actinobacterium Thermobifida Fusca. FEBS J., 272, 2005
|
|
2IY4
| X-ray structure of Dps from Listeria monocytogenes | Descriptor: | FE (III) ION, NON-HEME IRON-CONTAINING FERRITIN | Authors: | Ilari, A, Bellapadrona, G, Stefanini, S, Chiancone, E. | Deposit date: | 2006-07-12 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | The Mutations Lys 114 --> Gln and Asp 126 --> Asn Disrupt an Intersubunit Salt Bridge and Convert Listeria Innocua Dps Into its Natural Mutant Listeria Monocytogenes Dps. Effects on Protein Stability at Low Ph. Proteins, 66, 2007
|
|
2X17
| |
4AW8
| X-ray structure of ZinT from Salmonella enterica in complex with zinc ion and PEG | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Metal-binding protein ZinT, SODIUM ION, ... | Authors: | Alaleona, F, Ilari, A, Battistoni, A, Petrarca, P, Chiancone, E. | Deposit date: | 2012-06-01 | Release date: | 2013-06-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Salmonella Enterica Zint Structure, Zinc Affinity and Interaction with the High-Affinity Uptake Protein Znua Provide Insight Into the Management of Periplasmic Zinc. Biochim.Biophys.Acta, 1840, 2014
|
|
4BBP
| X-ray structure of zinc bound ZnuA in complex with RDS51 | Descriptor: | 1-[(2-chlorophenyl)methyl]-N-hydroxy-4-phenyl-1H-pyrrole-3-carboxamide, SULFATE ION, ZINC ABC TRANSPORTER, ... | Authors: | Alaleona, F, Ilari, A, Di Santo, R, Battistoni, A, Chiancone, E. | Deposit date: | 2012-09-27 | Release date: | 2013-10-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Salmonella Enterica Serovar Typhimurium Growth is Inhibited by the Concomitant Binding of Zn(II) and a Pyrrolyl-Hydroxamate to Znua, the Soluble Component of the Znuabc Transporter. Biochim.Biophys.Acta, 1860, 2016
|
|
4AYH
| The X-ray structure of zinc bound ZinT | Descriptor: | METAL-BINDING PROTEIN YODA, SULFATE ION, ZINC ION | Authors: | Alaleona, F, Ilari, A, Battistoni, A, Petrarca, P, Chiancone, E. | Deposit date: | 2012-06-21 | Release date: | 2013-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The Salmonella Enterica Zint Structure, Zinc Affinity and Interaction with the High-Affinity Uptake Protein Znua Provide Insight Into the Management of Periplasmic Zinc. Biochim.Biophys.Acta, 1840, 2014
|
|
4ARH
| X ray structure of the periplasmic zinc binding protein ZinT from Salmonella enterica | Descriptor: | METAL-BINDING PROTEIN YODA, SULFATE ION | Authors: | Alaleona, F, Ilari, A, Battistoni, A, Petrarca, P, Chiancone, E. | Deposit date: | 2012-04-24 | Release date: | 2013-05-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Salmonella Enterica Zint Structure, Zinc Affinity and Interaction with the High-Affinity Uptake Protein Znua Provide Insight Into the Management of Periplasmic Zinc. Biochim.Biophys.Acta, 1840, 2014
|
|
2C41
| X-ray structure of Dps from Thermosynechococcus elongatus | Descriptor: | CHLORIDE ION, DPS FAMILY DNA-BINDING STRESS RESPONSE PROTEIN, TETRAETHYLENE GLYCOL, ... | Authors: | Ilari, A, Franceschini, S, Ceci, P, Chiancone, E. | Deposit date: | 2005-10-14 | Release date: | 2006-10-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Antioxidant Dps Protein from the Thermophilic Cyanobacterium Thermosynechococcus Elongatus. FEBS J., 273, 2006
|
|
3KPF
| |
8QYT
| Human Pyridoxine-5'-phosphate oxidase in complex with PLP | Descriptor: | BETA-MERCAPTOETHANOL, FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Antonelli, L, Ilari, A, Fiorillo, A. | Deposit date: | 2023-10-26 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase. Protein Sci., 33, 2024
|
|
8QYW
| |
4UQV
| |
2X50
| Crystal structure of Trypanothione reductase from Leishmania infantum in complex with NADPH and silver | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SILVER ION, ... | Authors: | Baiocco, P, Ilari, A, Colotti, G. | Deposit date: | 2010-02-03 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania Infantum Proliferation Acs Med.Chem.Lett., 2, 2011
|
|
4ZQ0
| |
6TMM
| BIL2 domain from T.thermophila BUBL1 locus (C1A-N143A) | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | Authors: | Chiarini, V, Ilari, A. | Deposit date: | 2019-12-04 | Release date: | 2020-12-16 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (2.398 Å) | Cite: | Structural basis of ubiquitination mediated by protein splicing in early Eukarya. Biochim Biophys Acta Gen Subj, 1865, 2021
|
|
7NVP
| Trypanothione reductase from Trypanosoma brucei in complex with N-{4-methoxy-3-[(4-methoxyphenyl)sulfamoyl]phenyl}-5-nitrothiophene-2-carboxamide | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, N(1),N(8)-bis(glutathionyl)spermidine reductase, ... | Authors: | Battista, T, Fiorillo, A, Colotti, G, Ilari, A. | Deposit date: | 2021-03-15 | Release date: | 2022-03-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.153 Å) | Cite: | Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach. Acs Infect Dis., 8, 2022
|
|
5M5J
| Thioredoxin reductase from Giardia duodenalis | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, Thioredoxin reductase | Authors: | Fiorillo, A, Ilari, A, Lalle, M. | Deposit date: | 2016-10-21 | Release date: | 2017-05-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX. Eur J Med Chem, 135, 2017
|
|
8PF4
| Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Exertier, C, Ilari, A, Fiorillo, A, Antonelli, L. | Deposit date: | 2023-06-15 | Release date: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J.Med.Chem., 67, 2024
|
|