 | | PRD_000901 | | Name: | thiomuracin A derivative | | Formula: | C53 H54 N13 O9 S6 | | Definition date: | 2012-12-26 | | Last modified: | 2023-11-03 |
|
 | | PRD_000197 | | Name: | ALPHA LICHENICIDIN PREPEPTIDE | | Formula: | C142 H226 N36 O41 S5 | | Description: | LICHENICIDIN VK21 IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL
MATURATION OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR, AND
SER INTO DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS
WITH CYSTEINE. THIOETHER BONDS WITH CYSTEINE RESULT IN FOUR RINGS.
THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000198 | | Name: | BETA LICHENICIDIN PREPEPTIDE | | Formula: | C133 H200 N36 O37 S4 | | Description: | LICHENICIDIN VK21 IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL
MATURATION OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR, AND
SER INTO DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS
WITH CYSTEINE. THIOETHER BONDS WITH CYSTEINE RESULT IN FOUR RINGS.
THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_001255 | | Name: | Promothiocin A | | Formula: | C36 H47 N11 O8 S2 | | Definition date: | 2014-12-10 | | Last modified: | 2023-11-03 |
|
 | | PRD_000143 | | Name: | Cyclosporin D | | Formula: | C64 H115 N11 O12 S | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
CYCLOSPORIN D IS A NATURAL ANALOG OF CYCLOSPORIN A,
OBTAINED FROM A DIFFERENT NUTRIENT BROTH AND
DIFFERS FROM CYCLOSPORIN IN RESIDUE 6 (ABA6VAL). | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000194 | | Name: | ACTAGARDINE | | Formula: | C81 H124 N20 O23 S4 | | Description: | ACTAGARDINE IS A TRICYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION
OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR AND SER INTO
DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS WITH
CYSTEINE. THE THIOETHER BONDS WITH CYSTEINE RESULT IN THREE
RING STRUCTURES. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND
CLEAVAGE OF THE MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000195 | | Name: | Cinnamycin | | Formula: | C89 H127 N25 O25 S3 | | Description: | CINNAMYCIN IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION
OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR AND SER INTO
DEHYDRATED AMINO ACIDS AND THE FORMATION OF THIOETHER BONDS WITH
CYSTEINE. THE 14-19 BETA-METHYLLANTHIONINE THIOETHER BOND IS OXIDIZED
TO A SULFOXIDE. THE THIOETHER BONDS WITH CYSTEINE RESULT IN THREE
RING STRUCTURES, CROSSLINK BETWEEN SER AND LYS RESULT IN THE FOURTH
RING. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000196 | | Name: | EPILANCIN 15X | | Formula: | C145 H241 N41 O33 S3 | | Description: | Epilancin 15X is a tricyclic peptide. thioether bonds with cysteine
result in three rings along the peptide chain. Post Translational
maturation of lantibiotics involves the enzymic conversion of Thr and
Ser into dehydrated amino acids and the formation of thioether bonds
with cysteine. This is followed by membrane translocation and
cleavage of the modified precursor. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000199 | | Name: | Mersacidin | | Formula: | C80 H120 N20 O21 S4 | | Description: | MERSACIDIN IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION
OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR, AND SER INTO
DEHYDRATED AA AND THE FORMATION OF THIOETHER BONDS WITH CYSTEINE. THE
CARBOXY-TERMINAL BETA-METHYLLANTHIONINE UNDERGOES
DECARBOXYLATION. THIOETHER BONDS WITH CYSTEINE RESULT IN FOUR
RINGS. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000200 | | Name: | Nisin A | | Formula: | C141 H233 N41 O38 S7 | | Description: | Nisin Z is a heptacyclic peptide. Post Translational maturation of
lantibiotics involves the enzymic conversion of Thr, and Ser into
dehydrated AA and the formation of thioether bonds with cysteine.
Thioether bonds with cysteine result in five cyclic structures along
the peptide chain. This is followed by membrane translocation and
cleavage of the modified precursor. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000221 | | Name: | Nosiheptide | | Formula: | C51 H46 N13 O11 S6 | | Description: | NOSIHEPTIDE IS A HETROCYCLIC THIOPEPTIDE, CONSISTING OF FIVE THIAZOLES AND ONE 3-HYDROXYPYRIDINE RINGS. A MODIFIED
INDOLE RING NO1(14) IS LINKED VIA THE SIDE CHAINS OF 3-HYDROXY 3GL(6) AND CYS(8). THE OBSERVED C-TERMINAL AMINO GROUP
NH2(13) IS LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED REMNANT OF A SER C-TERMINAL RESIDUE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000225 | | Name: | GE2270a | | Formula: | C56 H58 N15 O10 S6 | | Description: | GEA2270A IS A THIOPEPTIDE CONSISTING OF ONE
PYRIDINE, ONE OXAZOLE AND FIVE THIAZOLE RINGS.
THE OBSERVED C-TERMINAL AMINO GROUP NH2(15) IS
LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED
REMNANT OF A SER C-TERMINAL RESIDUE. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000491 | | Name: | Echinomycin | | Formula: | C51 H64 N12 O12 S2 | | Description: | ECHINOMYCIN IS A BICYCLIC OCTADEPSIPEPTIDE.
BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI, AND A THIOACETAL BOND BETWEEN
RESIDUES 3 AND 7.
THE TWO QUINOXALINE CHROMOPHORES ARE LINKED
TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000492 | | Name: | uk63052 | | Formula: | C56 H68 N10 O14 S2 | | Description: | QUINOMYCIN UK63052 IS A BICYCLIC OCTADEPSIPEPTIDE.
BICYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI, AND A THIOACETAL BOND BETWEEN
RESIDUES 3 AND 7.
THE TWO HYDROXYQUINOXALINE CHROMOPHORES ARE LINKED
TO THE D-SERINE RESIDUES, RESIDUES 1 AND 5. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000762 | | Name: | METHANOBACTIN MB-OB3B | | Formula: | C45 H56 Cu N10 O16 S5 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000764 | | Name: | CYCLOSPORIN D, 5,7 mutation | | Formula: | C64 H117 N11 O12 S | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
CYCLOSPORIN D IS A NATURAL ANALOG OF CYCLOSPORIN A,
OBTAINED IN DIFFERENT NUTRIENT BROTH AND
DIFFERS FROM CYCLOSPORIN IN RESIDUE 6 (ABA6VAL).
THE CYCLOSPORIN D MOLECULE WAS MODIFIED AT
POSITIONS 5 AND 7 TO BE
(6,7-DIHYDRO)4-[(E)-BUTENYL]-4,N-DIMETHYL-THREONINE AND
(2-S-METHYL)-SARCOSINE, RESPECTIVELY. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_002366 | | Name: | Phalloidin | | Formula: | C35 H48 N8 O11 S | | Definition date: | 2021-12-22 | | Last modified: | 2023-05-09 |
|
 | | PRD_900106 | | Name: | 6-S-alpha-D-mannopyranosyl-6-thio-alpha-D-mannopyranose | | Formula: | C12 H22 O10 S | | Description: | oligosaccharide with S-glycosidic bond between monosaccharides | | Definition date: | 2020-07-29 | | Last modified: | 2020-08-05 |
|
 | | PRD_002307 | | Name: | Phalloidin | | Formula: | C35 H48 N8 O11 S | | Definition date: | 2018-09-19 | | Last modified: | 2018-09-19 |
|
 | | PRD_001172 | | Name: | nosiheptide bound form | | Formula: | C51 H53 N13 O12 S6 | | Definition date: | 2014-12-10 | | Last modified: | 2014-12-10 |
|
 | | PRD_001219 | | Name: | Lantibiotic 107891 | | Formula: | C94 H127 Cl N26 O26 S5 | | Description: | NAI-107 IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR, AND SER INTO DEHYDRATED AA AND THE FORMATION OF THIOETHER BONDS WITH CYSTEINE. THE CARBOXY-TERMINAL BETA-METHYLLANTHIONINE UNDERGOES DECARBOXYLATION. THIOETHER BONDS WITH CYSTEINE RESULT IN FOUR RINGS. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE MODIFIED PRECURSOR. | | Definition date: | 2014-03-05 | | Last modified: | 2014-03-05 |
|
 | | PRD_001072 | | Name: | Thiocillin GE2270 analogue NVP-LFF571 | | Formula: | C60 H72 N13 O13 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_001073 | | Name: | Thiocillin GE2270 analogue NVP-LDK733 | | Formula: | C55 H64 N13 O11 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_001074 | | Name: | Thiocillin GE2270 analogue NVP-LDI028 | | Formula: | C55 H64 N13 O10 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
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