8R4O

Salt inducible kinase 3 in complex with inhibitor

Summary for 8R4O

• Entry DOI: 10.2210/pdb8r4o/pdb
• Descriptor: Serine/threonine-protein kinase SIK3, scFvH1, 2-[bis(fluoranyl)methoxy]-4-[6-(2-cyanopropan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]-~{N}-[(1~{R},2~{S})-2-fluoranylcyclopropyl]-6-methoxy-benzamide, ... (5 entities in total)
• Functional Keywords: kinase inhibitor complex ampk-like salt-induced kinase, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 400964.29

Authors

Kack, H.,Oster, L. (deposition date: 2023-11-14, release date: 2024-03-27, Last modification date: 2024-05-08)

• Primary citation: Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H.; The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.; J.Biol.Chem., 300:107201-107201, 2024; PubMed: 38508313; DOI: 10.1016/j.jbc.2024.107201

Experimental method

X-RAY DIFFRACTION (2.725 Å)