8K7L

Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol

Summary for 8K7L

Entry DOI	10.2210/pdb8k7l/pdb
Descriptor	Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	alpha-galactosidase, glycosidase, iminosugar, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	94502.50
Authors	Li, H.Y.,Huang, K.F.,Ko, T.P.,Cheng, W.C. (deposition date: 2023-07-26, release date: 2024-04-10)
Primary citation	Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4:908-918, 2024 Cited by PubMed: 38559739 DOI: 10.1021/jacsau.3c00684 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation