8JG8

The crystal structure of human aurka kinase domain in the complex with aurka-compound 25

Summary for 8JG8

• Entry DOI: 10.2210/pdb8jg8/pdb
• Descriptor: Aurora kinase A, 4-[5-[3-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine (2 entities in total)
• Functional Keywords: inhibitor kinase, cytokine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 30925.51

Authors

Zhu, C.J.,Zhang, Z.M. (deposition date: 2023-05-19, release date: 2024-04-17)

• Primary citation: Tang, G.,Wang, W.,Zhu, C.,Huang, H.,Chen, P.,Wang, X.,Xu, M.,Sun, J.,Zhang, C.J.,Xiao, Q.,Gao, L.,Zhang, Z.M.,Yao, S.Q.; Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.; Angew.Chem.Int.Ed.Engl., 63:e202316394-e202316394, 2024; PubMed: 38248139; DOI: 10.1002/anie.202316394

Experimental method

X-RAY DIFFRACTION (2.90002335195 Å)