8FX5

Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline

Summary for 8FX5

• Entry DOI: 10.2210/pdb8fx5/pdb
• EMDB information: 29524
• Descriptor: Muscarinic acetylcholine receptor M4, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: 7 transmembrane receptor, signaling protein-immune system complex, membrane protein, membrane protein-signaling protein-immune system complex, membrane protein-signaling protein complex, membrane protein/signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 153174.46

Authors

Vuckovic, Z.,Mobbs, J.I.,Glukhova, A.,Sexton, P.M.,Danev, R.,Thal, D.M. (deposition date: 2023-01-23, release date: 2023-09-13)

• Primary citation: Burger, W.A.C.,Pham, V.,Vuckovic, Z.,Powers, A.S.,Mobbs, J.I.,Laloudakis, Y.,Glukhova, A.,Wootten, D.,Tobin, A.B.,Sexton, P.M.,Paul, S.M.,Felder, C.C.,Danev, R.,Dror, R.O.,Christopoulos, A.,Valant, C.,Thal, D.M.; Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.; Nat Commun, 14:5440-5440, 2023; PubMed: 37673901; DOI: 10.1038/s41467-023-41199-5

Experimental method

ELECTRON MICROSCOPY (2.45 Å)