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7ZYP

Crystal Structure of EGFR-T790M/C797S in Complex with Reversible Aminopyrimidine 9

Summary for 7ZYP
Entry DOI10.2210/pdb7zyp/pdb
DescriptorEpidermal growth factor receptor, propan-2-yl 2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywordsegfr, t790m/c797s, inhibitor, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight38425.47
Authors
Niggenaber, J.,Kleinboelting, S.,Mueller, M.P.,Rauh, D. (deposition date: 2022-05-25, release date: 2023-05-03, Last modification date: 2024-02-07)
Primary citationGrabe, T.,Jeyakumar, K.,Niggenaber, J.,Schulz, T.,Koska, S.,Kleinbolting, S.,Beck, M.E.,Muller, M.P.,Rauh, D.
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.
Acs Med.Chem.Lett., 14:591-598, 2023
Cited by
PubMed: 37197473
DOI: 10.1021/acsmedchemlett.2c00514
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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