7W0L
Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule
Summary for 7W0L
Entry DOI | 10.2210/pdb7w0l/pdb |
EMDB information | 32243 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | complex, gpcr, dimerization, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 223298.45 |
Authors | Yue, Y.,Liu, L.E.,Wu, L.J.,Xu, F.,Hanson, M. (deposition date: 2021-11-18, release date: 2022-07-27, Last modification date: 2022-08-03) |
Primary citation | Yue, Y.,Liu, L.,Wu, L.J.,Wu, Y.,Wang, L.,Li, F.,Liu, J.,Han, G.W.,Chen, B.,Lin, X.,Brouillette, R.L.,Breault, E.,Longpre, J.M.,Shi, S.,Lei, H.,Sarret, P.,Stevens, R.C.,Hanson, M.A.,Xu, F. Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29:688-697, 2022 Cited by PubMed: 35817871DOI: 10.1038/s41594-022-00797-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.57 Å) |
Structure validation
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