7F83

Crystal Structure of a receptor in Complex with inverse agonist

Summary for 7F83

• Entry DOI: 10.2210/pdb7f83/pdb
• Descriptor: Growth hormone secretagogue receptor type 1,Soluble cytochrome b562, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone (3 entities in total)
• Functional Keywords: gpcr, ghrelin, inverse agonist, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 97531.02

Authors

Xu, Z.,Shao, Z. (deposition date: 2021-07-01, release date: 2022-01-19, Last modification date: 2023-11-29)

• Primary citation: Qin, J.,Cai, Y.,Xu, Z.,Ming, Q.,Ji, S.Y.,Wu, C.,Zhang, H.,Mao, C.,Shen, D.D.,Hirata, K.,Ma, Y.,Yan, W.,Zhang, Y.,Shao, Z.; Molecular mechanism of agonism and inverse agonism in ghrelin receptor.; Nat Commun, 13:300-300, 2022; PubMed: 35027551; DOI: 10.1038/s41467-022-27975-9

Experimental method

X-RAY DIFFRACTION (2.94 Å)