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7F83

Crystal Structure of a receptor in Complex with inverse agonist

Summary for 7F83
Entry DOI10.2210/pdb7f83/pdb
DescriptorGrowth hormone secretagogue receptor type 1,Soluble cytochrome b562, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone (3 entities in total)
Functional Keywordsgpcr, ghrelin, inverse agonist, signaling protein
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight97531.02
Authors
Xu, Z.,Shao, Z. (deposition date: 2021-07-01, release date: 2022-01-19, Last modification date: 2023-11-29)
Primary citationQin, J.,Cai, Y.,Xu, Z.,Ming, Q.,Ji, S.Y.,Wu, C.,Zhang, H.,Mao, C.,Shen, D.D.,Hirata, K.,Ma, Y.,Yan, W.,Zhang, Y.,Shao, Z.
Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
Nat Commun, 13:300-300, 2022
Cited by
PubMed: 35027551
DOI: 10.1038/s41467-022-27975-9
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.94 Å)
Structure validation

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