6OBA

The beta2 adrenergic receptor bound to a negative allosteric modulator

Summary for 6OBA

Entry DOI	10.2210/pdb6oba/pdb
Descriptor	Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor, CHOLESTEROL, (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, ... (4 entities in total)
Functional Keywords	g protein coupled receptors, signal transduction, allosteric modulators, membrane protein, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	57939.26
Authors	Liu, X.,Stobel, A.,Kaindl, J.,Dengler, D.,ClarK, M.,Mahoney, J.,Korczynska, M.,Matt, R.A.,Hubner, H.,Xu, X.,Stanek, M.,Hirata, K.,Shoichet, B.,Sunahara, R.,Gmeiner, R.,Kobilka, B.K. (deposition date: 2019-03-20, release date: 2020-03-25, Last modification date: 2023-10-11)
Primary citation	Liu, X.,Kaindl, J.,Korczynska, M.,Stossel, A.,Dengler, D.,Stanek, M.,Hubner, H.,Clark, M.J.,Mahoney, J.,Matt, R.A.,Xu, X.,Hirata, K.,Shoichet, B.K.,Sunahara, R.K.,Kobilka, B.K.,Gmeiner, P. An allosteric modulator binds to a conformational hub in the beta2adrenergic receptor. Nat.Chem.Biol., 16:749-755, 2020 Cited by PubMed: 32483378 DOI: 10.1038/s41589-020-0549-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation