5XGM

Crystal structure of EGFR 696-1022 T790M in complex with Go6976

Summary for 5XGM

• Entry DOI: 10.2210/pdb5xgm/pdb
• Related: 5XGN
• Descriptor: Epidermal growth factor receptor, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole (3 entities in total)
• Functional Keywords: egfr t790m, go6976, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38029.02

Authors

Kong, L.L.,Yun, C.H. (deposition date: 2017-04-14, release date: 2017-10-11, Last modification date: 2023-11-22)

• Primary citation: Kong, L.L.,Ma, R.,Yao, M.Y.,Yan, X.E.,Zhu, S.J.,Zhao, P.,Yun, C.H.; Structural pharmacological studies on EGFR T790M/C797S.; Biochem. Biophys. Res. Commun., 488:266-272, 2017; PubMed: 28456628; DOI: 10.1016/j.bbrc.2017.04.138

Experimental method

X-RAY DIFFRACTION (2.952 Å)