5UGM

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Edaglitazone

Summary for 5UGM

Entry DOI	10.2210/pdb5ugm/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (5R)-5-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dione, nonanoic acid, ... (4 entities in total)
Functional Keywords	nuclear receptors, tzds, drug design, therapeutic targets, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	64168.75
Authors	Shang, J.,Kojetin, D.J. (deposition date: 2017-01-09, release date: 2018-01-17, Last modification date: 2024-03-06)
Primary citation	Shang, J.,Brust, R.,Mosure, S.A.,Bass, J.,Munoz-Tello, P.,Lin, H.,Hughes, T.S.,Tang, M.,Ge, Q.,Kamekencka, T.M.,Kojetin, D.J. Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7:-, 2018 Cited by PubMed: 30575522 DOI: 10.7554/eLife.43320 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation